GB1357011A - Method of stabilizing heparinized non-thrombogenic plastic surfaces - Google Patents

Method of stabilizing heparinized non-thrombogenic plastic surfaces

Info

Publication number
GB1357011A
GB1357011A GB4613571A GB4613571A GB1357011A GB 1357011 A GB1357011 A GB 1357011A GB 4613571 A GB4613571 A GB 4613571A GB 4613571 A GB4613571 A GB 4613571A GB 1357011 A GB1357011 A GB 1357011A
Authority
GB
United Kingdom
Prior art keywords
heparinised
groups
plastic
oct
dialdehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4613571A
Inventor
J G Eriksson
H R Lagergren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aminkemi AB
Original Assignee
Aminkemi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE450671A external-priority patent/SE377277B/xx
Application filed by Aminkemi AB filed Critical Aminkemi AB
Publication of GB1357011A publication Critical patent/GB1357011A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification

Abstract

1357011 Heparinised plastics AMINKEMI AB 4 Oct 1971 [5 Oct 1970 7 April 1971] 46135/71 Heading B2E In. a method for stabilising a heparinised plastic surface having surface-bonded cationic groups bonded to heparin to render the surface non thranbogenic, the heparinised surface is brought into contact with a dialdehyde having 0-4 CH 2 groups between the two aldehyde groups. Plastic surfaces which may be heparinised are made from polyethylene, polypropylene, polyvinyl chloride, polystyrene and polytetrafluoroethylene. Elastomers and cellulose derivatives are also suitable. To make the plastic surface receptive to heparinisation it is treated with a cationic surface active agent, e.g. containing an alkyl chain of at least 4 carbon atoms. Other suitable agents are primary, secondary and tertiary amines and their salts as well as quaternary ammonium compounds, pyridinium and guanidinium salts which have C 2+ alkyl attached as disclosed in British Patent No. 1,130,345. Glutandialdehyde is the preferred dialdehyde and may be used in 0.1-5% aqueous solution.
GB4613571A 1970-10-05 1971-10-04 Method of stabilizing heparinized non-thrombogenic plastic surfaces Expired GB1357011A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1348570 1970-10-05
SE450671A SE377277B (en) 1971-04-07 1971-04-07

Publications (1)

Publication Number Publication Date
GB1357011A true GB1357011A (en) 1974-06-19

Family

ID=26654530

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4613571A Expired GB1357011A (en) 1970-10-05 1971-10-04 Method of stabilizing heparinized non-thrombogenic plastic surfaces

Country Status (1)

Country Link
GB (1) GB1357011A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124200A2 (en) * 1983-04-27 1984-11-07 Becton Dickinson and Company Heparinization of plasma treated substrates
EP0212209A1 (en) * 1985-07-29 1987-03-04 Koken Company Limited A production process of an antithrombogenic and antiadhesive material for medical use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124200A2 (en) * 1983-04-27 1984-11-07 Becton Dickinson and Company Heparinization of plasma treated substrates
EP0124200A3 (en) * 1983-04-27 1987-01-07 Becton, Dickinson And Company Heparinization of plasma treated substrates
EP0212209A1 (en) * 1985-07-29 1987-03-04 Koken Company Limited A production process of an antithrombogenic and antiadhesive material for medical use

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years