GB1353331A - Process for preparing halobenzoic acids - Google Patents
Process for preparing halobenzoic acidsInfo
- Publication number
- GB1353331A GB1353331A GB1107771A GB1107771A GB1353331A GB 1353331 A GB1353331 A GB 1353331A GB 1107771 A GB1107771 A GB 1107771A GB 1107771 A GB1107771 A GB 1107771A GB 1353331 A GB1353331 A GB 1353331A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- group
- alkoxy
- alkenyloxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
1353331 5 - Halo - 4 - amino - 2 - (alkoxy or alkenyloxy) benzole acids and their derivatives TEIKOKU HORMONE MFG CO Ltd 23 April 1971 [24 April 1970 (2)] 11077/71 Heading C2C 5 - Halo - 4 - amino - 2 - (alkoxy or alkenyloxy)-benzoic acids of the general formula wherein A is an alkyl or alkenyl group and X is a halogen atom, are prepared by reaction of a 4-amino-2-(alkoxy or alkenyloxy)-benzoic acid of the general formula with an N-halo acid amide or imide; and may then be converted to N-(dialkylaminoalkyl)-5- halo-4-amino-2-(alkoxy or alkenyloxy)-benzamides of the general formula wherein R 2 is an alkylene group and each of R 3 and R 4 is an alkyl group, and acid addition salts thereof by (a) reaction with a haloformic acid ester of the general formula XCOOR 1 , wherein R 1 is an alkyl, alkenyl or aralkyl group, followed by a dialkylaminoalkylamine of the general formula H 2 NR 2 NR 3 R 4 ; (b) reaction with a heterocyclic compound of the general formula wherein each of R 5 , R 6 , R, and R 8 is a nitrogen atom or a CH group, at least two of them in each ring being CH groups, G is a sulphur or carbon atom and X is an oxygen or sulphur atom, G being a carbon atom when Z is a sulphur atom, followed by a dialkylaminoalkylamine of the fifth general formula above; and (c) reaction with a compound of the general formula R 13 R 14 P-N(R 12 )-R 2 NR 3 R 4 , wherein each of R 13 and R 14 is an alkoxy or phenoxy group, or a group of formula -N(R 12 )-R 2 NR 3 R 4 or -N(R 2 NR 3 R 4 )-P[N(R 12 )R 2 NR 3 R 4 ] 2 , or R 13 and R 14 together form an alkylenedioxy or ophenylenedioxy group, and R 12 is a hydrogen atom, or R 12 and R 13 together form a P-N bond; followed optionally by salification of the product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3340771A GB1353332A (en) | 1970-04-24 | 1971-04-23 | Phosphorus derivatives of n-substituted alkylene diamines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3474870A JPS5010573B1 (en) | 1970-04-24 | 1970-04-24 | |
JP3474770A JPS5525182B1 (en) | 1970-04-24 | 1970-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1353331A true GB1353331A (en) | 1974-05-15 |
Family
ID=26373595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1107771A Expired GB1353331A (en) | 1970-04-24 | 1971-04-23 | Process for preparing halobenzoic acids |
Country Status (4)
Country | Link |
---|---|
CA (1) | CA945564A (en) |
DE (1) | DE2119724B2 (en) |
FR (1) | FR2093454A5 (en) |
GB (1) | GB1353331A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010108A (en) * | 1988-03-17 | 1991-04-23 | Poli Industria Chimica S.P.A. | N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations |
WO2005023808A2 (en) * | 2003-09-09 | 2005-03-17 | Alizyme Therapeutics Limited | Process for the preparation of renzapride and intermediates thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1068726B (en) * | 1976-11-24 | 1985-03-21 | Rotta Research Lab | QUATERNARY AMMONIC DERIVATIVES OF L ADAMANTAN FOR ANTI-MICROBIAL ACTIVITY |
-
1971
- 1971-04-22 DE DE19712119724 patent/DE2119724B2/en not_active Withdrawn
- 1971-04-23 CA CA111,249A patent/CA945564A/en not_active Expired
- 1971-04-23 GB GB1107771A patent/GB1353331A/en not_active Expired
- 1971-04-26 FR FR7114779A patent/FR2093454A5/fr not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010108A (en) * | 1988-03-17 | 1991-04-23 | Poli Industria Chimica S.P.A. | N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations |
WO2005023808A2 (en) * | 2003-09-09 | 2005-03-17 | Alizyme Therapeutics Limited | Process for the preparation of renzapride and intermediates thereof |
WO2005023808A3 (en) * | 2003-09-09 | 2005-07-07 | Alizyme Therapeutics Ltd | Process for the preparation of renzapride and intermediates thereof |
US7189852B2 (en) | 2003-09-09 | 2007-03-13 | Alizyme Therapeutics Limited | Synthesis |
Also Published As
Publication number | Publication date |
---|---|
DE2119724A1 (en) | 1971-12-30 |
DE2119724B2 (en) | 1976-04-29 |
FR2093454A5 (en) | 1972-01-28 |
CA945564A (en) | 1974-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |