GB1352125A - Antigenic extracts - Google Patents

Antigenic extracts

Info

Publication number
GB1352125A
GB1352125A GB1352125DA GB1352125A GB 1352125 A GB1352125 A GB 1352125A GB 1352125D A GB1352125D A GB 1352125DA GB 1352125 A GB1352125 A GB 1352125A
Authority
GB
United Kingdom
Prior art keywords
proteinaceous
brucella
surfactant
agglutinogenic
precipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB1352125A publication Critical patent/GB1352125A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/098—Brucella

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1352125 Antigenic extracts WELLCOME FOUNDATION Ltd 30 June 1971 [16 July 1970] 34457/70 Heading A5B A proteinaceous non-agglutinogenic material, immunogenic in respect of infections of virulent Brucella spp., and free from lipopolysaccharides and formyl groups, is produced by extracting the live bacterial cells of a non- agglutinating strain of a species of the genus Brucella, e.g. Brucella abortus, such as a rough variant of Brucella abortus strain 45/20, in aqueous suspension with a surfactant agent, adding a water-miscible organic solvent to precipitate the extract, e.g. an alkanol having 1 to 3 carbon atoms, acetone, dioxane, and members of the Cellosolve (Trade Mark) and Carbitol (Trade Mark) families, and separating the proteinaceous precipitate from the other materials in the suspension preferably by centrifugation. The surfactant is preferably an anionic surfactant such as an alkali metal (e.g. sodium) salt of dodecyl sulphate. The live cells may be treated with an anionic surfactant at room temperature for 17 to 24 hours. Sterile injectable vaccine preparations comprise the proteinaceous, non-agglutinogenic material and a pharmaceutically acceptable solid or liquid carrier and optionally an aluminium or potash alum adjuvant. The preparation may be freezedried.
GB1352125D 1970-07-16 1970-07-16 Antigenic extracts Expired GB1352125A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3445770 1970-07-16

Publications (1)

Publication Number Publication Date
GB1352125A true GB1352125A (en) 1974-05-08

Family

ID=10365885

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1352125D Expired GB1352125A (en) 1970-07-16 1970-07-16 Antigenic extracts

Country Status (5)

Country Link
DE (1) DE2134930A1 (en)
FR (1) FR2100920B1 (en)
GB (1) GB1352125A (en)
IE (1) IE35396B1 (en)
NL (1) NL7109451A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016728A1 (en) * 1992-02-25 1993-09-02 The Texas A & M University System Improved vaccin against brucella abortus
US5718903A (en) * 1987-03-30 1998-02-17 The Texas A&M University System Vaccine comprising Brucella abortus which has O polysaccharide antigen absent

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148877A (en) * 1975-12-29 1979-04-10 Choay S. A. Fraction capable of inducing in vivo a resistance to bacterial infections, process for obtaining said fraction from bacteria and drugs containing said fraction
FR2506615A1 (en) * 1981-06-01 1982-12-03 Merieux Inst Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells
FR2524315B1 (en) * 1982-04-02 1985-07-12 Merieux Inst NOVEL ANTIGEN FOR THE RESEARCH OF BRUCELLAL SKIN HYPERSENSITIVITY, PARTICULARLY IN MAN, AND METHOD FOR PREPARING THE SAME

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5718903A (en) * 1987-03-30 1998-02-17 The Texas A&M University System Vaccine comprising Brucella abortus which has O polysaccharide antigen absent
WO1993016728A1 (en) * 1992-02-25 1993-09-02 The Texas A & M University System Improved vaccin against brucella abortus

Also Published As

Publication number Publication date
IE35396B1 (en) 1976-02-04
DE2134930A1 (en) 1972-01-20
IE35396L (en) 1972-01-16
FR2100920A1 (en) 1972-03-24
FR2100920B1 (en) 1976-04-16
NL7109451A (en) 1972-01-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee