GB1352125A - Antigenic extracts - Google Patents
Antigenic extractsInfo
- Publication number
- GB1352125A GB1352125A GB1352125DA GB1352125A GB 1352125 A GB1352125 A GB 1352125A GB 1352125D A GB1352125D A GB 1352125DA GB 1352125 A GB1352125 A GB 1352125A
- Authority
- GB
- United Kingdom
- Prior art keywords
- proteinaceous
- brucella
- surfactant
- agglutinogenic
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/098—Brucella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
1352125 Antigenic extracts WELLCOME FOUNDATION Ltd 30 June 1971 [16 July 1970] 34457/70 Heading A5B A proteinaceous non-agglutinogenic material, immunogenic in respect of infections of virulent Brucella spp., and free from lipopolysaccharides and formyl groups, is produced by extracting the live bacterial cells of a non- agglutinating strain of a species of the genus Brucella, e.g. Brucella abortus, such as a rough variant of Brucella abortus strain 45/20, in aqueous suspension with a surfactant agent, adding a water-miscible organic solvent to precipitate the extract, e.g. an alkanol having 1 to 3 carbon atoms, acetone, dioxane, and members of the Cellosolve (Trade Mark) and Carbitol (Trade Mark) families, and separating the proteinaceous precipitate from the other materials in the suspension preferably by centrifugation. The surfactant is preferably an anionic surfactant such as an alkali metal (e.g. sodium) salt of dodecyl sulphate. The live cells may be treated with an anionic surfactant at room temperature for 17 to 24 hours. Sterile injectable vaccine preparations comprise the proteinaceous, non-agglutinogenic material and a pharmaceutically acceptable solid or liquid carrier and optionally an aluminium or potash alum adjuvant. The preparation may be freezedried.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3445770 | 1970-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1352125A true GB1352125A (en) | 1974-05-08 |
Family
ID=10365885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1352125D Expired GB1352125A (en) | 1970-07-16 | 1970-07-16 | Antigenic extracts |
Country Status (5)
Country | Link |
---|---|
DE (1) | DE2134930A1 (en) |
FR (1) | FR2100920B1 (en) |
GB (1) | GB1352125A (en) |
IE (1) | IE35396B1 (en) |
NL (1) | NL7109451A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016728A1 (en) * | 1992-02-25 | 1993-09-02 | The Texas A & M University System | Improved vaccin against brucella abortus |
US5718903A (en) * | 1987-03-30 | 1998-02-17 | The Texas A&M University System | Vaccine comprising Brucella abortus which has O polysaccharide antigen absent |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148877A (en) * | 1975-12-29 | 1979-04-10 | Choay S. A. | Fraction capable of inducing in vivo a resistance to bacterial infections, process for obtaining said fraction from bacteria and drugs containing said fraction |
FR2506615A1 (en) * | 1981-06-01 | 1982-12-03 | Merieux Inst | Vaccine against brucellosis in humans - contg. phenol insoluble fraction of defatted Brucella abortus cells |
FR2524315B1 (en) * | 1982-04-02 | 1985-07-12 | Merieux Inst | NOVEL ANTIGEN FOR THE RESEARCH OF BRUCELLAL SKIN HYPERSENSITIVITY, PARTICULARLY IN MAN, AND METHOD FOR PREPARING THE SAME |
-
1970
- 1970-07-16 GB GB1352125D patent/GB1352125A/en not_active Expired
-
1971
- 1971-06-24 IE IE81271A patent/IE35396B1/en unknown
- 1971-07-08 NL NL7109451A patent/NL7109451A/xx unknown
- 1971-07-13 DE DE19712134930 patent/DE2134930A1/en active Pending
- 1971-07-15 FR FR7125920A patent/FR2100920B1/fr not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5718903A (en) * | 1987-03-30 | 1998-02-17 | The Texas A&M University System | Vaccine comprising Brucella abortus which has O polysaccharide antigen absent |
WO1993016728A1 (en) * | 1992-02-25 | 1993-09-02 | The Texas A & M University System | Improved vaccin against brucella abortus |
Also Published As
Publication number | Publication date |
---|---|
IE35396B1 (en) | 1976-02-04 |
DE2134930A1 (en) | 1972-01-20 |
IE35396L (en) | 1972-01-16 |
FR2100920A1 (en) | 1972-03-24 |
FR2100920B1 (en) | 1976-04-16 |
NL7109451A (en) | 1972-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |