GB1348938A - Process for the detection and determination of specific binding proteins and their corresponding bindable substances - Google Patents

Process for the detection and determination of specific binding proteins and their corresponding bindable substances

Info

Publication number
GB1348938A
GB1348938A GB5873871A GB5873871A GB1348938A GB 1348938 A GB1348938 A GB 1348938A GB 5873871 A GB5873871 A GB 5873871A GB 5873871 A GB5873871 A GB 5873871A GB 1348938 A GB1348938 A GB 1348938A
Authority
GB
United Kingdom
Prior art keywords
component
bindable
determined
antibody
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5873871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB1348938A publication Critical patent/GB1348938A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y10S436/818—Human chorionic gonadotropin

Abstract

1348938 Determination of specific binding proteins &c ORGANON LABORATORIES Ltd 17 Dec 1971 [28 Dec 1970] 58738/71 Heading B1X Specific binding proteins or the substances specifically bindable by the proteins are determined using as reagents in the reaction between the protein and the bindable substance (1) a known amount of a coupling product of the bindable substance with an enzyme, and (2) a known amount of an antibody against the component being determined, the antibody being in insoluble form when the component being determined is a specific binding protein or in soluble form when the component being determined is the bindable substance in which case there is subsequently added to the reaction mixture (3) an antibody to component (2) in insoluble form, and determining the enzyme activity in the liquid or solid phase of the reaction system as a measure of the amount of protein or bindable substance to be determined. The bindable substances may be antigens or haptenes and the binding proteins may be antibodies to the bindable substances. The antibody in insoluble form may be prepared by cross-linking the antibody with glutaraldehyde or chloroformic acid cross-linked to make it insoluble ethyl ester or by binding it chemically or physically to an insoluble carrier material. Examples relate to determination of HCG, insulin, anti-insulin, oestradiol cortisol, corticoid-binding globulin, the antibodies of component (2) or component (3) being made insoluble by coupling them to m-aminobenzyloxymethylcellulose, microcrystalline cellulose. Test packs including the reagents are disclosed.
GB5873871A 1970-12-28 1971-12-17 Process for the detection and determination of specific binding proteins and their corresponding bindable substances Expired GB1348938A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL707018838A NL154599B (en) 1970-12-28 1970-12-28 PROCEDURE FOR DETERMINING AND DETERMINING SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES, AND TEST PACKAGING.

Publications (1)

Publication Number Publication Date
GB1348938A true GB1348938A (en) 1974-03-27

Family

ID=19811894

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5873871A Expired GB1348938A (en) 1970-12-28 1971-12-17 Process for the detection and determination of specific binding proteins and their corresponding bindable substances

Country Status (20)

Country Link
US (1) US3839153A (en)
JP (3) JPS5834783B1 (en)
AT (1) AT320145B (en)
AU (1) AU467394B2 (en)
BE (1) BE777309A (en)
BR (1) BR7108553D0 (en)
CA (1) CA964560A (en)
CH (1) CH557030A (en)
DE (1) DE2164768B2 (en)
DK (1) DK150690C (en)
EG (1) EG11604A (en)
ES (1) ES398372A1 (en)
FI (1) FI54034C (en)
FR (1) FR2120835A5 (en)
GB (1) GB1348938A (en)
IL (1) IL38371A (en)
IT (1) IT965020B (en)
NL (1) NL154599B (en)
SE (1) SE398557B (en)
ZA (1) ZA718332B (en)

Cited By (3)

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US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids

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US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5391478A (en) * 1988-05-10 1995-02-21 E. I. Du Pont De Nemours And Company Assay device and immunoassay

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Publication number Publication date
DK150690B (en) 1987-05-25
JPS58117455A (en) 1983-07-13
EG11604A (en) 1977-08-15
CA964560A (en) 1975-03-18
NL7018838A (en) 1972-06-30
IL38371A (en) 1974-06-30
SE398557B (en) 1977-12-27
AU467394B2 (en) 1975-11-27
US3839153A (en) 1974-10-01
BR7108553D0 (en) 1973-07-03
BE777309A (en) 1972-04-17
DE2164768A1 (en) 1972-07-20
JPS58117456A (en) 1983-07-13
FI54034B (en) 1978-05-31
JPS5834783B1 (en) 1983-07-28
NL154599B (en) 1977-09-15
AU3698671A (en) 1973-06-21
DE2164768B2 (en) 1976-01-22
ZA718332B (en) 1972-09-27
ES398372A1 (en) 1975-06-16
DK150690C (en) 1988-06-06
CH557030A (en) 1974-12-13
FI54034C (en) 1978-09-11
IT965020B (en) 1974-01-31
IL38371A0 (en) 1972-02-29
FR2120835A5 (en) 1972-08-18
AT320145B (en) 1975-01-27

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PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years