GB1338172A - Local anesthetic compositions - Google Patents

Local anesthetic compositions

Info

Publication number
GB1338172A
GB1338172A GB2242071A GB2242071A GB1338172A GB 1338172 A GB1338172 A GB 1338172A GB 2242071 A GB2242071 A GB 2242071A GB 2242071 A GB2242071 A GB 2242071A GB 1338172 A GB1338172 A GB 1338172A
Authority
GB
United Kingdom
Prior art keywords
alkyl
vasoconstrictor
local anesthetic
local anaesthetics
anesthetic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2242071A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pennwalt Corp
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of GB1338172A publication Critical patent/GB1338172A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1338172 Local anaesthetics PENNWALT CORP 19 April 1971 [24 Feb 1970] 22420/71 Heading A5B Compounds of the general formula below are employed with the concomitant use of a vasoconstrictor as local anaesthetics for animals. The invention also includes compositions comprising such a compound or a salt thereof and a vasoconstrictor, with or without a pharmaceutical carrier. Preferred compounds are those known as pentazocine and cyclazocine. The formula is: wherein R<SP>1</SP> and R<SP>2</SP> are each H or C 1-6 alkyl, R<SP>3</SP> is H, Me, C 1-6 alkanoyl or pyridine carbonyl and Z is H, Me, phenyl C 1-4 alkyl, C 3-6 alkenyl or cyclopropyl C 1-6 alkyl. The preferred vasoconstrictor is epinephrine.
GB2242071A 1970-02-24 1971-04-19 Local anesthetic compositions Expired GB1338172A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1421170A 1970-02-24 1970-02-24
US42727173A 1973-12-21 1973-12-21
US52132574 UST941017I4 (en) 1970-02-24 1974-11-06 Defensive publication

Publications (1)

Publication Number Publication Date
GB1338172A true GB1338172A (en) 1973-11-21

Family

ID=27360042

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2242071A Expired GB1338172A (en) 1970-02-24 1971-04-19 Local anesthetic compositions

Country Status (6)

Country Link
US (1) UST941017I4 (en)
CA (1) CA949879A (en)
DE (1) DE2108726A1 (en)
FR (1) FR2081535B1 (en)
GB (1) GB1338172A (en)
NL (1) NL7102372A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294840A (en) 1979-02-12 1981-10-13 Sterling Drug Inc. Ketazocine anesthetic method of use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent
US5750141A (en) * 1993-04-08 1998-05-12 The University Of Queensland Administration of vaso-active agent and therapeutic agent

Also Published As

Publication number Publication date
CA949879A (en) 1974-06-25
DE2108726A1 (en) 1971-09-09
NL7102372A (en) 1971-08-26
FR2081535A1 (en) 1971-12-03
FR2081535B1 (en) 1974-09-27
UST941017I4 (en) 1975-12-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees