GB1333700A - Phenothiazine derivatives - Google Patents
Phenothiazine derivativesInfo
- Publication number
- GB1333700A GB1333700A GB3377372A GB3377372A GB1333700A GB 1333700 A GB1333700 A GB 1333700A GB 3377372 A GB3377372 A GB 3377372A GB 3377372 A GB3377372 A GB 3377372A GB 1333700 A GB1333700 A GB 1333700A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- reacting
- alkyl
- july
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1333700 Phenothiazines RHONE-POULENC SA 19 July 1972 [21 July 1971] 33773/72 Heading C2C Compounds of the general Formula (I) (X = methylsulphonyl, dimethylsulphamoyl; A = trimethylene, 2-methyltrimethylene R 1 = H, C 1-4 alkyl; R = H, C 5-17 alkanoyl, alkenoyl or alkoxycarbonyl; B = C 2-5 alkylene) and their acid addition salts are prepared by (a) reacting a compound of the Formula (II) (Y = reactive ester residue) with a compound of the Formula (III) (b) reacting a compound of the Formula (IV) (R 2 = C 1-4 alkyl) with R 1 NHBOH, (c) reacting a compound of the Formula (VII) with YBOH or (d) selectively reducing a compound of the Formula (IX) (B 1 = C 1-4 alkylene; R 3 = C 1-4 alkyl), optionally followed, in each case by acylation and/or salt formation. The preparation of starting materials of Formula (II) is described. The above compounds are anti-emetics, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7126709A FR2146150B1 (en) | 1971-07-21 | 1971-07-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1333700A true GB1333700A (en) | 1973-10-10 |
Family
ID=9080680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3377372A Expired GB1333700A (en) | 1971-07-21 | 1972-07-19 | Phenothiazine derivatives |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5619349B1 (en) |
AR (2) | AR193118A1 (en) |
AT (1) | AT317234B (en) |
AU (1) | AU458571B2 (en) |
BE (1) | BE786583A (en) |
CH (1) | CH541578A (en) |
DE (1) | DE2235998C3 (en) |
ES (2) | ES405048A1 (en) |
FR (1) | FR2146150B1 (en) |
GB (1) | GB1333700A (en) |
NL (1) | NL7209698A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6154025B2 (en) | 2012-12-24 | 2017-06-28 | ニューロガストルクス,インコーポレイテッド | Method for treating GI tract disorders |
US9844554B2 (en) * | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE562299A (en) * | 1956-11-15 | |||
DE1092476B (en) * | 1958-04-24 | 1960-11-10 | Rhone Poulenc Sa | Process for the preparation of phenthiazine derivatives |
-
0
- BE BE786583D patent/BE786583A/en unknown
-
1971
- 1971-07-21 FR FR7126709A patent/FR2146150B1/fr not_active Expired
-
1972
- 1972-07-13 NL NL7209698A patent/NL7209698A/xx not_active Application Discontinuation
- 1972-07-19 AU AU44741/72A patent/AU458571B2/en not_active Expired
- 1972-07-19 GB GB3377372A patent/GB1333700A/en not_active Expired
- 1972-07-19 JP JP7243572A patent/JPS5619349B1/ja active Pending
- 1972-07-20 CH CH1085572A patent/CH541578A/en not_active IP Right Cessation
- 1972-07-21 AR AR24320972A patent/AR193118A1/en active
- 1972-07-21 DE DE19722235998 patent/DE2235998C3/en not_active Expired
- 1972-07-21 ES ES405048A patent/ES405048A1/en not_active Expired
- 1972-07-21 AT AT629772A patent/AT317234B/en not_active IP Right Cessation
- 1972-10-23 ES ES407867A patent/ES407867A1/en not_active Expired
-
1973
- 1973-01-15 AR AR24612373A patent/AR193181A1/en active
Also Published As
Publication number | Publication date |
---|---|
JPS5619349B1 (en) | 1981-05-07 |
DE2235998C3 (en) | 1982-01-07 |
AU4474172A (en) | 1974-01-24 |
AR193181A1 (en) | 1973-03-30 |
FR2146150A1 (en) | 1973-03-02 |
AU458571B2 (en) | 1975-02-27 |
FR2146150B1 (en) | 1974-09-06 |
DE2235998A1 (en) | 1973-02-01 |
ES405048A1 (en) | 1975-07-16 |
NL7209698A (en) | 1973-01-23 |
AT317234B (en) | 1974-08-26 |
ES407867A1 (en) | 1975-11-16 |
DE2235998B2 (en) | 1981-04-02 |
BE786583A (en) | 1973-01-22 |
AR193118A1 (en) | 1973-03-30 |
CH541578A (en) | 1973-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |