GB1333332A - Trihydroxy-oestratriene derivatives and a process for their manufacture - Google Patents
Trihydroxy-oestratriene derivatives and a process for their manufactureInfo
- Publication number
- GB1333332A GB1333332A GB1042971*[A GB1042971A GB1333332A GB 1333332 A GB1333332 A GB 1333332A GB 1042971 A GB1042971 A GB 1042971A GB 1333332 A GB1333332 A GB 1333332A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- cyclopentyloxy
- prepared
- give
- estratrienes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
1333332 3 - Cyclopentylethers of steroid triols and their esters CIBA-GEIGY AG 21 April 1971 [24 April 1970 (2)] 10429/71 Heading C2U Novel steroids of the formula and their 16,17-diacetates are prepared (1) by etherification of the corresponding 3-ols or metal derivatives thereof, using a reactive derivative of cyclopentanol or (2) by reduction of 3-cyclopentyloxy - 17 - acyloxy - 7α - methyl - 16α, 17α- epoxy - #<SP>135,,(10)</SP> - estratrienes (prepared from 7α - methyl - estrone via its 3-cyclopentyl ether and a 17-enol-acrylate thereof), to give a mixture of the 2 epimeric diols; or (3) by treatment of 3 - cyclopentyloxy - 7α - methyl - #<SP>1,3,5(10),16</SP>- estratetraene (prepared by etherification of the 3-ol) with OsO 4 to give the 16α,17α-diol; or (4) by reduction of 3-cyclopentyloxy-7α-methyl- 16α - acryloxy - 17 - oxo - #<SP>1,3,5(10)</SP> - estratrienes, to give the 16α,17#-diol. Resulting free ols may be acetylated. In (1), in addition to the 16, 17-diols and their acetates, other 16, 17- diacylates may be used, in which case the products must subsequently be hydrolysed. 3 - Cyclopentyloxy - 7α - methyl - 16α - acetoxy- 17 - oxo - #<SP>1,3,5(10)</SP> - estratriene is prepared by the action of mild acid on 3-cyclopentyloxy 7α - methyl - 17 - acetoxy - 16α,17α - epoxy- #<SP>1,3,5(10)</SP>-estratriene. The novel steroids are stated to possess uterotropic, estrogenic and blastocyte implantation inhibiting properties, and they may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH622070A CH540243A (en) | 1970-04-24 | 1970-04-24 | Process for the production of a new, highly estrogenic steroid |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1333332A true GB1333332A (en) | 1973-10-10 |
Family
ID=4306174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1042971*[A Expired GB1333332A (en) | 1970-04-24 | 1971-04-21 | Trihydroxy-oestratriene derivatives and a process for their manufacture |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT312827B (en) |
CH (2) | CH540243A (en) |
CS (1) | CS157121B2 (en) |
GB (1) | GB1333332A (en) |
SU (1) | SU437279A3 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10159217A1 (en) | 2001-11-27 | 2003-06-05 | Schering Ag | 17alpha-alkyl-17ß-oxy-estratrienes and intermediates for their preparation, use of 17alpha-alkyl-17ß-oxy-estratriene for the preparation of medicaments and pharmaceutical preparations |
-
1970
- 1970-04-24 CH CH622070A patent/CH540243A/en not_active IP Right Cessation
- 1970-04-24 CH CH1870472A patent/CH536296A/en not_active IP Right Cessation
-
1971
- 1971-04-21 GB GB1042971*[A patent/GB1333332A/en not_active Expired
- 1971-04-23 AT AT273272A patent/AT312827B/en not_active IP Right Cessation
- 1971-04-23 SU SU1815034A patent/SU437279A3/en active
- 1971-04-23 CS CS174073*1A patent/CS157121B2/cs unknown
Also Published As
Publication number | Publication date |
---|---|
CH536296A (en) | 1973-04-30 |
AT312827B (en) | 1974-01-25 |
SU437279A3 (en) | 1974-07-25 |
CS157121B2 (en) | 1974-08-23 |
CH540243A (en) | 1973-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |