GB1327552A - 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation - Google Patents
1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparationInfo
- Publication number
- GB1327552A GB1327552A GB1324872A GB1324872A GB1327552A GB 1327552 A GB1327552 A GB 1327552A GB 1324872 A GB1324872 A GB 1324872A GB 1324872 A GB1324872 A GB 1324872A GB 1327552 A GB1327552 A GB 1327552A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- prepared
- substituted
- hydrogen
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1327552 Benzylpyrimidone derivatives MORTON-NORWICH PRODUCTS Inc 21 March 1972 [25 March 1971] 13248/72 Heading C2C Novel compounds of Formula I in which R is substituted in the 3- or 4-position of the phenyl group and is hydrogen, C 1-8 alkyl, carbomethoxy, carboxy, carboxamido, dimethylamino, or aminomethyl when substituted in the 4-position or is trifluoromethyl when substituted in the 3-position, and R 1 is phenyl or hydrogen provided that R and R 1 are not simultaneously hydrogen are prepared by hydrogenation of the novel compounds of formula wherein R 2 is R or cyano which are prepared by reacting 2-hydroxypyrimidine with a compound of formula wherein X is halogen. Intermediates are prepared as follows: p-octylbenzyl chloride is obtained by action of thionyl chloride on p-octylbenzyl alcohol prepared by reduction of p-octylbenzoic acid; p-dimethylaminobenzyl chloride hydrochloride is obtained by action of thionyl chloride on the alcohol; and 1 - p - cyanobenzyl) - 2 (1H) - pyrimidone is obtained by reacting α-bromo-p-toluonitrile with 2-hydroxypyrimidine. Pharmaceutical compositions in conventional forms for per oral administration and having anti-convulsant and tranquillizing activity, comprise a novel compound of Formula I above and a carrier therefor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12814371A | 1971-03-25 | 1971-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1327552A true GB1327552A (en) | 1973-08-22 |
Family
ID=22433854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1324872A Expired GB1327552A (en) | 1971-03-25 | 1972-03-21 | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation |
Country Status (15)
| Country | Link |
|---|---|
| AR (1) | AR196986A1 (en) |
| AT (1) | AT315184B (en) |
| AU (1) | AU458346B2 (en) |
| BE (1) | BE781158A (en) |
| CA (1) | CA965416A (en) |
| CH (1) | CH568299A5 (en) |
| DE (1) | DE2214474A1 (en) |
| DK (1) | DK129523B (en) |
| ES (1) | ES400964A1 (en) |
| FR (1) | FR2130686B1 (en) |
| GB (1) | GB1327552A (en) |
| IL (1) | IL39003A (en) |
| NL (1) | NL7203883A (en) |
| PH (1) | PH9703A (en) |
| ZA (1) | ZA721832B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047894A1 (en) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Substituted benzoylcyclohexane diones for use as herbicides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE562987A (en) * | 1956-12-05 | |||
| US3681349A (en) * | 1970-03-05 | 1972-08-01 | Morton Norwich Products Inc | 1-(substituted benzyl) tetrahydro-2-(1h) pyrimidones |
-
1972
- 1972-03-16 IL IL39003A patent/IL39003A/en unknown
- 1972-03-17 ZA ZA721832A patent/ZA721832B/en unknown
- 1972-03-20 AR AR241030A patent/AR196986A1/en active
- 1972-03-20 ES ES400964A patent/ES400964A1/en not_active Expired
- 1972-03-21 GB GB1324872A patent/GB1327552A/en not_active Expired
- 1972-03-21 AU AU40226/72A patent/AU458346B2/en not_active Expired
- 1972-03-22 DK DK133972AA patent/DK129523B/en unknown
- 1972-03-23 BE BE781158A patent/BE781158A/en unknown
- 1972-03-23 NL NL7203883A patent/NL7203883A/xx unknown
- 1972-03-23 CH CH434772A patent/CH568299A5/xx not_active IP Right Cessation
- 1972-03-23 AT AT254172A patent/AT315184B/en active
- 1972-03-24 CA CA138,099A patent/CA965416A/en not_active Expired
- 1972-03-24 FR FR7210486A patent/FR2130686B1/fr not_active Expired
- 1972-03-24 DE DE19722214474 patent/DE2214474A1/en active Pending
-
1974
- 1974-04-22 PH PH15764*UA patent/PH9703A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047894A1 (en) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Substituted benzoylcyclohexane diones for use as herbicides |
| US6825183B2 (en) | 1999-12-24 | 2004-11-30 | Bayer Aktiengesellschaft | Substituted benzoylcyclohexanediones for use as herbicides |
| US7244692B2 (en) | 1999-12-24 | 2007-07-17 | Bayer Aktiengesellschaft | Substituted benzoylcyclohexane diones for use as herbicides |
Also Published As
| Publication number | Publication date |
|---|---|
| AT315184B (en) | 1974-05-10 |
| AU458346B2 (en) | 1975-02-07 |
| PH9703A (en) | 1976-02-19 |
| DK129523C (en) | 1975-03-24 |
| CA965416A (en) | 1975-04-01 |
| AR196986A1 (en) | 1974-03-08 |
| ES400964A1 (en) | 1975-09-01 |
| NL7203883A (en) | 1972-09-27 |
| IL39003A (en) | 1975-02-10 |
| CH568299A5 (en) | 1975-10-31 |
| AU4022672A (en) | 1973-09-27 |
| BE781158A (en) | 1972-09-25 |
| DK129523B (en) | 1974-10-21 |
| DE2214474A1 (en) | 1972-10-05 |
| ZA721832B (en) | 1973-10-31 |
| FR2130686A1 (en) | 1972-11-03 |
| FR2130686B1 (en) | 1975-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE44055L (en) | Phthalanes | |
| GB1432576A (en) | Substituted phenylacetic acids | |
| GB1294763A (en) | 3-oxo-2,3-dihydro-1,4-benzoxazine derivatives | |
| IE36106L (en) | Isoindoline derivatives | |
| GB1256750A (en) | ||
| ATE69228T1 (en) | AMIDA COMBINATIONS. | |
| GB1363195A (en) | Propenylamine derivatives and process for the production thereof | |
| GB1342828A (en) | Pyrimidinyl-piperazines and processes for their preparation | |
| GB1327552A (en) | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation | |
| GB1336743A (en) | S-triazolo-1,5-a- 1,4- benzodiazepine derivatives and a process for their preparation | |
| GB1279543A (en) | Novel imidazolines, the preparation thereof and compositions containing the same | |
| GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
| GB1417539A (en) | Pyrazolo-qzinoline derivative and compositions thereof | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1474907A (en) | Pyrolidine derivatives | |
| GB1384523A (en) | Oxime derivatives and their preparation | |
| GB1242096A (en) | Benzobenzofuranooxepine compounds and process for preparing the same | |
| GB1276719A (en) | Benzomorphan derivatives and their salts | |
| GB1428933A (en) | 5-phenyl-sulphinyl-2-benzimidazolyl-carbamic acid esters and process for their manufacture | |
| GB1503626A (en) | Substituted piperazine derivative its preparation and compositions containing it | |
| IE32946B1 (en) | Phenethylamine derivatives and process for the manufacture thereof | |
| GB1325280A (en) | 3-substituted-as-triazino-5,6-c-quinolines | |
| GB1342753A (en) | Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof | |
| GB1186062A (en) | Benzonaphthyridine Derivatives | |
| GB1377610A (en) | 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |