GB1320069A - 1-methyl-4-piperidyl exo 2-phenylbicyclo 2,2,1 heptane-2- carboxylate and the salts thereof - Google Patents
1-methyl-4-piperidyl exo 2-phenylbicyclo 2,2,1 heptane-2- carboxylate and the salts thereofInfo
- Publication number
- GB1320069A GB1320069A GB5960471A GB5960471A GB1320069A GB 1320069 A GB1320069 A GB 1320069A GB 5960471 A GB5960471 A GB 5960471A GB 5960471 A GB5960471 A GB 5960471A GB 1320069 A GB1320069 A GB 1320069A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- exo
- piperidyl
- compound
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1-methyl-4-piperidyl Chemical group 0.000 title 1
- NKBWMBRPILTCRD-UHFFFAOYSA-N 2-Methylheptanoic acid Chemical compound CCCCCC(C)C(O)=O NKBWMBRPILTCRD-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- BAUWRHPMUVYFOD-UHFFFAOYSA-N 1-methylpiperidin-4-ol Chemical compound CN1CCC(O)CC1 BAUWRHPMUVYFOD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- JESWDXIHOJGWBP-UHFFFAOYSA-N bicyclo[2.2.1]heptane-3-carboxylic acid Chemical class C1CC2C(C(=O)O)CC1C2 JESWDXIHOJGWBP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F1/00—Springs
- F16F1/36—Springs made of rubber or other material having high internal friction, e.g. thermoplastic elastomers
- F16F1/40—Springs made of rubber or other material having high internal friction, e.g. thermoplastic elastomers consisting of a stack of similar elements separated by non-elastic intermediate layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Architecture (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1320069 2-Norbornanecarboxylic acid derivatives KNOLL AG CHEMISCHE FABRIKEN 22 Dec 1971 [29 Jan 1971] 59604/71 Heading C2C Novel compound 1-methyl-4-piperidyl exo-2- phenyl-2-norbomanecarboxylate and the acid addition and quaternary ammonium salts thereof. The said compound is obtained either by separating a mixture of the oxo and endo form of the ester by recrystallization from a hydrocarbon solvent or by reacting exo-2-phenyl-2- norbornanecarbonyl chloride with 1-methyl-4- piperidol. Pharmaceutical compositions, suitable for oral administration, contain the above novel compound or acid addition or quaternary ammonium salts thereof in association with therapeutically acceptable carriers. The compound possesses antichlolinergenic activity
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2104179A DE2104179C3 (en) | 1971-01-29 | 1971-01-29 | exo-2-phenyl-bicyclo- [2,2,1] -heptane-2- (N-methylpiperidol-4) -carboxylic acid ester and its salts, processes for their preparation and medicaments containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1320069A true GB1320069A (en) | 1973-06-13 |
Family
ID=5797265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5960471A Expired GB1320069A (en) | 1971-01-29 | 1971-12-22 | 1-methyl-4-piperidyl exo 2-phenylbicyclo 2,2,1 heptane-2- carboxylate and the salts thereof |
Country Status (10)
Country | Link |
---|---|
JP (2) | JPS5744669B1 (en) |
AT (2) | AT313279B (en) |
BE (1) | BE777042A (en) |
CA (1) | CA977758A (en) |
CH (1) | CH574410A5 (en) |
DE (1) | DE2104179C3 (en) |
FR (1) | FR2123519B1 (en) |
GB (1) | GB1320069A (en) |
NL (1) | NL7200327A (en) |
YU (1) | YU34677B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8207193B2 (en) | 2006-11-14 | 2012-06-26 | Astrazeneca Ab | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6110078A (en) * | 1984-06-26 | 1986-01-17 | 品川白煉瓦株式会社 | Lining structure for molten steel ladle |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL99113C (en) * | 1956-06-16 |
-
1971
- 1971-01-29 DE DE2104179A patent/DE2104179C3/en not_active Expired
- 1971-12-21 BE BE777042A patent/BE777042A/en unknown
- 1971-12-22 GB GB5960471A patent/GB1320069A/en not_active Expired
-
1972
- 1972-01-10 NL NL7200327A patent/NL7200327A/xx not_active Application Discontinuation
- 1972-01-21 YU YU158/72A patent/YU34677B/en unknown
- 1972-01-28 CH CH123672A patent/CH574410A5/xx not_active IP Right Cessation
- 1972-01-28 FR FR7202937A patent/FR2123519B1/fr not_active Expired
- 1972-01-28 JP JP47010446A patent/JPS5744669B1/ja active Pending
- 1972-01-28 AT AT67772A patent/AT313279B/en active
- 1972-01-28 AT AT67672A patent/AT313278B/en active
- 1972-01-28 CA CA133,445A patent/CA977758A/en not_active Expired
-
1981
- 1981-09-02 JP JP56137131A patent/JPS5775970A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8207193B2 (en) | 2006-11-14 | 2012-06-26 | Astrazeneca Ab | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
DE2104179A1 (en) | 1972-08-10 |
DE2104179B2 (en) | 1980-02-07 |
YU34677B (en) | 1979-12-31 |
JPS5745430B2 (en) | 1982-09-28 |
JPS5775970A (en) | 1982-05-12 |
DE2104179C3 (en) | 1980-10-02 |
AT313278B (en) | 1974-02-11 |
FR2123519A1 (en) | 1972-09-08 |
YU15872A (en) | 1979-07-10 |
NL7200327A (en) | 1972-08-01 |
FR2123519B1 (en) | 1975-08-01 |
CA977758A (en) | 1975-11-11 |
BE777042A (en) | 1972-06-21 |
AT313279B (en) | 1974-02-11 |
CH574410A5 (en) | 1976-04-15 |
JPS5744669B1 (en) | 1982-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |