GB1319528A - Medicine with proliferation-inhibiting action - Google Patents
Medicine with proliferation-inhibiting actionInfo
- Publication number
- GB1319528A GB1319528A GB4148570A GB4148570A GB1319528A GB 1319528 A GB1319528 A GB 1319528A GB 4148570 A GB4148570 A GB 4148570A GB 4148570 A GB4148570 A GB 4148570A GB 1319528 A GB1319528 A GB 1319528A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tumour
- homogenate
- fractions
- aug
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000035755 proliferation Effects 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 239000002504 physiological saline solution Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000005185 salting out Methods 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1319528 Tumour-inhibiting substance STIFTUNG ONOPHRIO 28 Aug 1970 [28 Aug 1969] 41485/70 Heading A5B A substance having tumour-inhibiting properties is obtained by incubating a homogenate of a tumour with a homogenate of the spleen of the person having the tumour, acidifying the incubated homogenate and optionally adding a lower (water-miscible) monohydric alcohol, filtering; adjusting the pH of the filtrate to about pH 7.5, removing the precipitate, adjusting the pH to about 2.5, removing the alcohol if present by evaporation at below 45C, salting out protein, extracting the precipitate with glacial acetic acid and obtaining two fractions from the extract by repeated precipitation with a) acetone and b) petroleum ether/ether. The fractions may be mixed and administered by injection in physiological saline.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691943699 DE1943699A1 (en) | 1969-08-28 | 1969-08-28 | Medicinal product with an anti-proliferation effect and process for the manufacture of this medicinal product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1319528A true GB1319528A (en) | 1973-06-06 |
Family
ID=5743984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4148570A Expired GB1319528A (en) | 1969-08-28 | 1970-08-28 | Medicine with proliferation-inhibiting action |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH537189A (en) |
| DE (1) | DE1943699A1 (en) |
| FR (1) | FR2068524B1 (en) |
| GB (1) | GB1319528A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK292182A (en) * | 1981-10-01 | 1983-04-02 | Otsuka Pharma Co Ltd | METHOD OF MANUFACTURING LYMOTOCYTES THAT ARE CYTOTOXIC TO CANCER CELLS, AND GLYCO-ASSOCIATED ANTIGEN FOR USE THEREOF |
-
1969
- 1969-08-28 DE DE19691943699 patent/DE1943699A1/en active Pending
-
1970
- 1970-08-26 CH CH1274770A patent/CH537189A/en not_active IP Right Cessation
- 1970-08-27 FR FR7031363A patent/FR2068524B1/fr not_active Expired
- 1970-08-28 GB GB4148570A patent/GB1319528A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH537189A (en) | 1973-05-31 |
| DE1943699A1 (en) | 1971-03-04 |
| FR2068524A1 (en) | 1971-08-27 |
| FR2068524B1 (en) | 1974-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLE | Entries relating assignments, transmissions, licences in the register of patents | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |