GB1317830A - Method for producing antibiotics namely rifamycins b and o - Google Patents

Method for producing antibiotics namely rifamycins b and o

Info

Publication number
GB1317830A
GB1317830A GB2630170A GB2630170A GB1317830A GB 1317830 A GB1317830 A GB 1317830A GB 2630170 A GB2630170 A GB 2630170A GB 2630170 A GB2630170 A GB 2630170A GB 1317830 A GB1317830 A GB 1317830A
Authority
GB
United Kingdom
Prior art keywords
ethyl acetate
rifamycin
extraction
rifamycins
crude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2630170A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1317830A publication Critical patent/GB1317830A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1317830 Antibiotics rifamycins B and O TAKEDA YAKUHIN KOGYO KK 1 June 1970 [30 May 1969] 26301/70 Heading C2A Rifamycin B and rifamycin O are produced by cultivating Streptomyces tolypophorus (I.F.O.-12554-cf. Specification 1,212,741) or its yellow mutant (I.F.O. 13151) in a nutrient medium containing at least one assimilable C source and at least one digestible N source in the presence of 0À005 to 0À5% of an inorganic iron compound under aerobic conditions. The medium is preferably aqueous and the iron may be ferrous or ferric chloride, sulphate, citrate, phosphate, iodide, oxide or hydroxide. Rifamycin O is obtained by extracting the culture broth at pH 7À2 with ethylacetate and adding a 1 : 10 mixture of diethyl ether and petroleum ether to the extract to precipitate a crude which is further purified by chromatography on carbon and then on silica gel. Rifamycin B is obtained from the aqueous layer after ethyl acetate extraction of the broth by adjusting to pH 2À5, extracting with ethyl acetate and precipitating a crude by the addition of petroleum ether. Further purification is by dissolution in ethyl acetate, extraction with aqueous phosphate, adjustment to pH 3À0, re-extraction into ethyl acetate and precipitation by addition of n-hexane, followed by crystallization from 1 : 1 ethyl acetate and acetone.
GB2630170A 1969-05-30 1970-06-01 Method for producing antibiotics namely rifamycins b and o Expired GB1317830A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4230769 1969-05-30

Publications (1)

Publication Number Publication Date
GB1317830A true GB1317830A (en) 1973-05-23

Family

ID=12632347

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2630170A Expired GB1317830A (en) 1969-05-30 1970-06-01 Method for producing antibiotics namely rifamycins b and o

Country Status (5)

Country Link
BE (1) BE751182A (en)
CH (1) CH547854A (en)
DE (1) DE2026595A1 (en)
FR (1) FR2043847A1 (en)
GB (1) GB1317830A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102405223A (en) * 2009-04-20 2012-04-04 意大利阿尔法韦士曼制药公司 Rifamycin derivatives
US8518949B2 (en) 2005-03-03 2013-08-27 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US9452157B2 (en) 2012-07-06 2016-09-27 Alfa Wassermann S.P.A Pharmaceutical compositions comprising rifaximin and amino acids, preparation methods and use thereof
US10285944B2 (en) 2005-03-07 2019-05-14 Alfasigma S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518949B2 (en) 2005-03-03 2013-08-27 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US10703763B2 (en) 2005-03-03 2020-07-07 Alfasigma S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US10285944B2 (en) 2005-03-07 2019-05-14 Alfasigma S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin
CN102405223A (en) * 2009-04-20 2012-04-04 意大利阿尔法韦士曼制药公司 Rifamycin derivatives
JP2012524060A (en) * 2009-04-20 2012-10-11 アルファ ワッセルマン ソシエタ ペル アチオニ Rifamycin derivative
US8318763B2 (en) 2009-04-20 2012-11-27 Alfa Wassermann S.P.A. Rifamycin derivatives
US9452157B2 (en) 2012-07-06 2016-09-27 Alfa Wassermann S.P.A Pharmaceutical compositions comprising rifaximin and amino acids, preparation methods and use thereof

Also Published As

Publication number Publication date
BE751182A (en) 1970-11-03
CH547854A (en) 1974-04-11
DE2026595A1 (en) 1970-12-10
FR2043847A1 (en) 1971-02-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees