GB1312196A - Nicotinic acid derivatives and a process for the manufacture thereof - Google Patents

Nicotinic acid derivatives and a process for the manufacture thereof

Info

Publication number
GB1312196A
GB1312196A GB5436571A GB5436571A GB1312196A GB 1312196 A GB1312196 A GB 1312196A GB 5436571 A GB5436571 A GB 5436571A GB 5436571 A GB5436571 A GB 5436571A GB 1312196 A GB1312196 A GB 1312196A
Authority
GB
United Kingdom
Prior art keywords
nicotinic acid
chloro
hydroxy
base addition
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5436571A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1312196A publication Critical patent/GB1312196A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

1312196 2 - Chloro - 6 - hydroxy - nicotinic acid F HOFFMANN-LA ROCHE & CO AG 23 Nov 1971 [23 Nov 1970 (2)] 54365/71 Heading C2C Novel 2 - chloro - 6 - hydroxy - nicotinic acid and base addition salts thereof are prepared by hydrolysis of 2,6-dichloro-nicotinic acid or a base addition salt thereof, followed by acidification of the hydrolysis product and optional salification of the resulting free acid. Pharmaceutical compositions having hypolipidemic activity comprise, as active ingredient, 2- chloro-6-hydroxy-nicotinic acid or a pharmaceutically acceptable base addition salt thereof, in association with a compatible pharmaceutical carrier, and may be administered orally or parenterally.
GB5436571A 1970-11-23 1971-11-23 Nicotinic acid derivatives and a process for the manufacture thereof Expired GB1312196A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9229570A 1970-11-23 1970-11-23
US9229470A 1970-11-23 1970-11-23

Publications (1)

Publication Number Publication Date
GB1312196A true GB1312196A (en) 1973-04-04

Family

ID=26785491

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5436571A Expired GB1312196A (en) 1970-11-23 1971-11-23 Nicotinic acid derivatives and a process for the manufacture thereof

Country Status (9)

Country Link
AT (1) AT319241B (en)
CH (1) CH557817A (en)
DE (1) DE2157289A1 (en)
ES (1) ES397242A1 (en)
FR (1) FR2115359B1 (en)
GB (1) GB1312196A (en)
IL (1) IL38006A (en)
NL (1) NL7115453A (en)
SE (1) SE371195B (en)

Also Published As

Publication number Publication date
CH557817A (en) 1975-01-15
DE2157289A1 (en) 1972-05-31
ES397242A1 (en) 1975-03-01
AT319241B (en) 1974-12-10
FR2115359B1 (en) 1974-10-18
IL38006A (en) 1974-07-31
FR2115359A1 (en) 1972-07-07
SE371195B (en) 1974-11-11
NL7115453A (en) 1972-05-25
IL38006A0 (en) 1971-12-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees