GB1312055A - Alkanolamine derivatives - Google Patents
Alkanolamine derivativesInfo
- Publication number
- GB1312055A GB1312055A GB1873870A GB1312055DA GB1312055A GB 1312055 A GB1312055 A GB 1312055A GB 1873870 A GB1873870 A GB 1873870A GB 1312055D A GB1312055D A GB 1312055DA GB 1312055 A GB1312055 A GB 1312055A
- Authority
- GB
- United Kingdom
- Prior art keywords
- propanol
- alkyl
- butylamino
- chloro
- phenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1312055 Pharmaceutical compositions IMPERIAL CHEMICAL INDUSTRIES Ltd 19 April 1971 [20 April 1970] 18738/70 Addition to 1269775 Heading A5B [Also in Division C2] Pharmaceutical compositions, suitable for oral or parenteral administration, contain novel alkanolamines of the formula: wherein R<SP>1</SP> is H or alkyl; R<SP>2</SP> is H or alkyl which may optionally be substituted by one or more substituents selected from OH, aryl and aryloxy, or cycloalkyl; wherein R<SP>3</SP> is H or alkyl; R<SP>4</SP> is branched chain butyl; R<SP>5</SP> is H, halogen, acylamino, alkyl, alkenyl, nitro, alkylthio, alkoxy, alkenyloxy or acyl; or esters thereof; or acid acid addition salts thereof: or compounds of the formula: wherein R<SP>7</SP> is alkyl, hydroxyalkyl, alkoxyalkyl cycloalkyl, alkenyl, aralkyl or substituted aralkyl; and R<SP>8</SP> is H, halogen, alkyl, alkenyl, nitro, alkylthio, alkoxy, alkenyloxy or acyl; or esters thereof; or acid addition salts thereof; or one of the following compounds: 1-[2-chloro-4-(N-n-butyl carbamoyl) phenoxy]-3-t-butyl-amino-2-propanol, 1-[2-chloro-4-(N-n-pentylcarbamoyl)-phenoxy]-3-t-butylamino - 2 - propanol, 1-(2-chloro-4-N-cyclohexylcarbamoylphenoxy)-3-t-butylamino-2-propanol, 1-(2-chloro-4- N-cyclohexycarbamoyl phenoxy)-3-isopropylamino-2-propanol, 1-[2-bromo-4-(N-n-hexylcarbamoylphenoxy]-3-t-butylamino - 2 - propanol, 1-(4-N-isopropylcarbamoyl- 2 - methoxyphenoxy)-3-t-butylamino-2-propanol; or 1-[4-N-nbutyl-carbamoyl)-2-methoxyphenoxy] - 3 - tbutylamino-2-propanol; or the esters thereof or the acid addition salts thereof in association with pharmaceutically acceptable diluents or carriers therefor. The compositions may be used in the treatment or prophylaxis of heart diseases, and some of the compounds possess selective #-adrenergic blocking activity. The above compositions may also contain one or more drugs selected from sedatives, for example phenobarbitone, meprobate and chlorpromazine; vasodilators, for example glyceryl trinitrate, pentaerythritol tetranitrate and isosorbide dinitrate; diuretics, for example chlorothiazide; hypotensive agents, for example reserpine, bethanidine and guanethidine; myocardial depressants, for example quinidine; agents used in the treatment of Parkinson's disease, for example benzhexol; cardiotonic agents, for example digitalis preparations; and sympathomimetic bronchodilators, for example isoprenaline, orciprenaline, adrenaline and ephedrine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1873870 | 1970-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1312055A true GB1312055A (en) | 1973-04-04 |
Family
ID=10117568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1873870A Expired GB1312055A (en) | 1970-04-20 | 1970-04-20 | Alkanolamine derivatives |
Country Status (6)
Country | Link |
---|---|
AU (1) | AU2785571A (en) |
BE (1) | BE765965R (en) |
FR (1) | FR2092059B2 (en) |
GB (1) | GB1312055A (en) |
IE (1) | IE35262B1 (en) |
ZA (1) | ZA712310B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1236523C2 (en) * | 1962-02-15 | 1975-06-12 | Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim | PROCESS FOR THE PRODUCTION OF BASIC PHENYLAETHERS AND THEIR SALTS |
GB1269775A (en) * | 1968-07-18 | 1972-04-06 | Ici Ltd | Alkanolamine derivatives |
-
1970
- 1970-04-20 GB GB1873870A patent/GB1312055A/en not_active Expired
-
1971
- 1971-04-07 IE IE444/71A patent/IE35262B1/en unknown
- 1971-04-13 ZA ZA712310A patent/ZA712310B/en unknown
- 1971-04-19 AU AU27855/71A patent/AU2785571A/en not_active Expired
- 1971-04-19 FR FR7113812A patent/FR2092059B2/fr not_active Expired
- 1971-04-19 BE BE765965A patent/BE765965R/en active
Also Published As
Publication number | Publication date |
---|---|
BE765965R (en) | 1971-10-19 |
ZA712310B (en) | 1972-01-26 |
FR2092059B2 (en) | 1974-08-30 |
FR2092059A2 (en) | 1972-01-21 |
IE35262B1 (en) | 1975-12-24 |
AU2785571A (en) | 1972-10-26 |
IE35262L (en) | 1971-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |