GB1301366A - - Google Patents
Info
- Publication number
- GB1301366A GB1301366A GB1301366DA GB1301366A GB 1301366 A GB1301366 A GB 1301366A GB 1301366D A GB1301366D A GB 1301366DA GB 1301366 A GB1301366 A GB 1301366A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- alkyl
- reacting
- prepared
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1301366 Dibenzazepine derivatives RHONEPOULENC SA 7 Aug 1970 [7 Aug 1969] 38279/70 Heading C2C Novel compounds I: (in which each of R and R<SP>1</SP> is H, C 1-5 alkyl, C 1-5 hydroxyalkyl, hydroxyalkoxyalkyl of 1-5 carbon atoms in each alkyl residue, or phenyl-C 1-5 alkyl optionally substituted in the phenyl nucleus by one or more of halogen, C 1-5 alkyl, C 1-5 alkoxy, NH 2 or CF 3 , R 1 is H or C 1-5 alkyl and one of the symbols X is Cl and the other symbols X are each H) and acid addition salts and quaternary ammonium derivatives thereof, are prepared by (a) reducing a compound II: or (b) reducing a compound III: (in which CH 2 R 2 has the same meaning as R<SP>1</SP> and R<SP>3</SP> is H, C 1-5 alkyl or phenyl-C 1-5 alkyl optionally substituted by one or more of halogen, C 1-5 alkyl, C 1-5 alkoxy or CF 3 ), or (c) reacting a compound IV: with a compound of formula R 2 CHO, or (d) reacting a compound V: (in which Ac is acyl) with a compound of formula R 2 CHO, and removing the acyl group in the resulting product by hydrolysis, or (e) reacting a compound IV with a compound of formula R 4 -Z (in which R 4 has the same meaning as R<SP>1</SP> but is not H, and Z is a reactive ester residue) or (f) replacing the radical Y in a compound VI: (in which Y is CN, alkoxycarbonyl, alkanoyl alkanesulphonyl or arylsulphonyl) by a hydrogen atom, or (g) reducing a compound VII: (in which R 5 is H or C 1-5 alkyl and R 6 is C 1-5 alkyl), and, if desired, converting a resulting compound into an acid addition salt or quaternary ammonium derivative. Compounds II are prepared by reacting a compound C: with hydroxylamine. Compounds X and intermediates therefor are prepared by the following reacting schemes A and B: Compounds III are prepared by acylation of com unds VIII: 2 - Chloro - 5 - methyl - 10 - ethoxycarbonylamino - 10,11 - dihydro - dibenzo[b,f]azepine is prepared by reacting ethyl chloroformate with 2 - chloro - 5 - methyl - 10 - amino - 10,11 - dihydrodibenzo[b,f]azepine. Pharmaceutical compositions for oral, rectal, parenteral or topical administration, comprise a compound I or a non-toxic acid addition salt or quaternary ammonium derivative thereof, together with a pharmaceutical carrier. The active ingredients have antidepressant, analgesic, anticonvulsive and tranquillizing activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6927226A FR2069831A1 (en) | 1969-08-07 | 1969-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1301366A true GB1301366A (en) | 1972-12-29 |
Family
ID=9038789
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1301366D Expired GB1301366A (en) | 1969-08-07 | 1970-08-07 | |
GB1301367D Expired GB1301367A (en) | 1969-08-07 | 1970-08-07 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1301367D Expired GB1301367A (en) | 1969-08-07 | 1970-08-07 |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS4939275B1 (en) |
AT (2) | AT301556B (en) |
BE (1) | BE754532A (en) |
CH (1) | CH516560A (en) |
CS (2) | CS163771B2 (en) |
DE (2) | DE2064879A1 (en) |
ES (2) | ES382564A1 (en) |
FR (1) | FR2069831A1 (en) |
GB (2) | GB1301366A (en) |
IE (1) | IE34441B1 (en) |
IL (1) | IL35070A0 (en) |
LU (1) | LU61484A1 (en) |
NL (1) | NL7011296A (en) |
OA (1) | OA03651A (en) |
PL (1) | PL82685B1 (en) |
SU (2) | SU370777A3 (en) |
ZA (1) | ZA705448B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2305177A (en) * | 1995-09-16 | 1997-04-02 | Agrevo Uk Ltd | Fungicidal amides |
EP1765768B1 (en) * | 2004-07-08 | 2013-11-06 | AstraZeneca AB | Substituted acids for the treatment of respiratory diseases |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2198942B1 (en) * | 1972-09-12 | 1975-03-14 | Rhone Poulenc Ind |
-
0
- BE BE754532D patent/BE754532A/en unknown
-
1969
- 1969-08-07 FR FR6927226A patent/FR2069831A1/fr not_active Withdrawn
-
1970
- 1970-07-29 OA OA53994A patent/OA03651A/en unknown
- 1970-07-30 NL NL7011296A patent/NL7011296A/xx unknown
- 1970-08-03 SU SU1466527A patent/SU370777A3/ru active
- 1970-08-03 SU SU1663229A patent/SU399124A3/ru active
- 1970-08-04 CS CS5442A patent/CS163771B2/cs unknown
- 1970-08-04 CS CS7446*A patent/CS163772B2/cs unknown
- 1970-08-06 LU LU61484D patent/LU61484A1/xx unknown
- 1970-08-06 IE IE1014/70A patent/IE34441B1/en unknown
- 1970-08-06 PL PL1970142553A patent/PL82685B1/en unknown
- 1970-08-06 IL IL35070A patent/IL35070A0/en unknown
- 1970-08-06 ZA ZA705448A patent/ZA705448B/en unknown
- 1970-08-06 CH CH1186870A patent/CH516560A/en not_active IP Right Cessation
- 1970-08-07 DE DE19702064879 patent/DE2064879A1/de active Pending
- 1970-08-07 GB GB1301366D patent/GB1301366A/en not_active Expired
- 1970-08-07 GB GB1301367D patent/GB1301367A/en not_active Expired
- 1970-08-07 DE DE19702039396 patent/DE2039396A1/en active Pending
- 1970-08-07 AT AT581571A patent/AT301556B/en not_active IP Right Cessation
- 1970-08-07 AT AT721170A patent/AT299211B/en not_active IP Right Cessation
- 1970-08-07 ES ES382564A patent/ES382564A1/en not_active Expired
- 1970-09-04 ES ES383390A patent/ES383390A1/en not_active Expired
-
1971
- 1971-04-13 JP JP46022821A patent/JPS4939275B1/ja active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2305177A (en) * | 1995-09-16 | 1997-04-02 | Agrevo Uk Ltd | Fungicidal amides |
EP1765768B1 (en) * | 2004-07-08 | 2013-11-06 | AstraZeneca AB | Substituted acids for the treatment of respiratory diseases |
Also Published As
Publication number | Publication date |
---|---|
LU61484A1 (en) | 1971-07-15 |
ES382564A1 (en) | 1973-05-01 |
OA03651A (en) | 1971-12-24 |
JPS4939275B1 (en) | 1974-10-24 |
ZA705448B (en) | 1971-04-28 |
BE754532A (en) | 1971-02-08 |
AT301556B (en) | 1972-09-11 |
DE2064879A1 (en) | 1972-02-10 |
IE34441L (en) | 1971-02-07 |
CH516560A (en) | 1971-12-15 |
SU399124A3 (en) | 1973-09-27 |
FR2069831A1 (en) | 1971-09-10 |
DE2039396A1 (en) | 1971-02-18 |
ES383390A1 (en) | 1973-02-16 |
CS163772B2 (en) | 1975-11-07 |
IE34441B1 (en) | 1975-05-14 |
IL35070A0 (en) | 1970-10-30 |
CS163771B2 (en) | 1975-11-07 |
GB1301367A (en) | 1972-12-29 |
NL7011296A (en) | 1971-02-09 |
SU370777A3 (en) | 1973-02-15 |
PL82685B1 (en) | 1975-10-31 |
AT299211B (en) | 1972-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |