GB1296561A - - Google Patents

Info

Publication number
GB1296561A
GB1296561A GB1296561DA GB1296561A GB 1296561 A GB1296561 A GB 1296561A GB 1296561D A GB1296561D A GB 1296561DA GB 1296561 A GB1296561 A GB 1296561A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
phenyl
antiviral
jan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1296561A publication Critical patent/GB1296561A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1296561 Antiviral &c medicines ELI LILLY & CO 28 Jan 1970 [28 Jan 1969] 4180/70 Heading A5B [Also in Division C2] Pharmaceutical compositions having antiviral and immune-suppressant activity comprise a carrier and compounds of the general formula: wherein R is α-naphthyl; C 5-8 cycloalkyl; 1- adamantyl or phenyl, optionally substituted by halogen, C 1-3 alkoxy, C 1-3 alkyl, amino, C 1-3 alkylamino, di-(C 1-3 alkyl)-amino, nitro or methyl substituted by 1-3 fluorine atoms, R' is H or phenyl; R"' is H or Me, n is 0, 1, 2 or 3, m is 0 or 1, Y is S or O, Z is S, O or N-R" wherein R" is H, C 1-3 alkyl or phenyl and Q is wherein m' is 3, 4, 5 or 6; R"" is halogen or C 1-3 alkyl; R""' is NO 2 , Me substituted by 1-3 fluorine atoms, C 1-3 alkoxy, carbo-C 1-3 alkoxy or C 1-3 alkyl sulphonyl or R"" and R''''' taken together, are methylene dioxy, p is 0, 1, 2, 3 or 4 and q is 0, 1 or 2.
GB1296561D 1969-01-28 1970-01-28 Expired GB1296561A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79474969A 1969-01-28 1969-01-28
US79475669A 1969-01-28 1969-01-28

Publications (1)

Publication Number Publication Date
GB1296561A true GB1296561A (en) 1972-11-15

Family

ID=27121543

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1296561D Expired GB1296561A (en) 1969-01-28 1970-01-28

Country Status (6)

Country Link
BE (1) BE744970A (en)
CY (1) CY777A (en)
DE (1) DE2003841C3 (en)
FR (1) FR2034500B1 (en)
GB (1) GB1296561A (en)
MY (1) MY7500001A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046770A (en) 1974-08-30 1977-09-06 Eli Lilly And Company N-(6-acyloxybenzothiazol-2-yl)-N'-phenyl (or substituted phenyl)ureas
US6380232B1 (en) * 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6906091B2 (en) 1999-08-13 2005-06-14 Uaf Technologies And Research, Llc Method of cancer treatment
US6930121B2 (en) 2000-09-26 2005-08-16 Uaf Technologies And Research, Llc Compounds and methods for use thereof in the treatment of viral infections
US6984654B2 (en) 1997-05-16 2006-01-10 Uaf Technologies And Research, Llc Cancer treatments and pharmaceutical compositions therefor
WO2006013054A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Substituted n-acyl-2-aminothiazoles
US20150344449A1 (en) * 2012-12-21 2015-12-03 Janssen R&D Ireland Antibacterial compounds
EP2945625A4 (en) * 2013-01-15 2016-09-14 Kineta Inc Anti-viral compounds

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
BE792606A (en) * 1972-01-06 1973-03-30 Ferlux NEW SEMICARBAZIDS AND THIOSEMICARBAZIDS AND THEIR PREPARATION
FR2186238A1 (en) * 1972-05-05 1974-01-11 Ferlux N-2-imidazolinyl-N'-acylhydrazides - with analgesic hypotensive and cardiac stimulant activity
US3932434A (en) * 1974-08-30 1976-01-13 Eli Lilly And Company N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted phenyl) ureas
ATE297900T1 (en) 1997-03-25 2005-07-15 Kowa Co ANILIDE COMPOUNDS AND MEDICATIONS CONTAINING SAME

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046770A (en) 1974-08-30 1977-09-06 Eli Lilly And Company N-(6-acyloxybenzothiazol-2-yl)-N'-phenyl (or substituted phenyl)ureas
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6653335B2 (en) 1995-04-12 2003-11-25 University Of Arizona Foundationa Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6984654B2 (en) 1997-05-16 2006-01-10 Uaf Technologies And Research, Llc Cancer treatments and pharmaceutical compositions therefor
US6906091B2 (en) 1999-08-13 2005-06-14 Uaf Technologies And Research, Llc Method of cancer treatment
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6720349B2 (en) 2000-09-26 2004-04-13 Uaf Technologies And Research, Llc Compounds for use in the treatment of cancer or viral infections
US6930121B2 (en) 2000-09-26 2005-08-16 Uaf Technologies And Research, Llc Compounds and methods for use thereof in the treatment of viral infections
US6380232B1 (en) * 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
WO2006013054A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Substituted n-acyl-2-aminothiazoles
US7407977B2 (en) 2004-08-05 2008-08-05 Hoffman-La Roche Inc. Substituted N-acyl-2-aminothiazoles
US20150344449A1 (en) * 2012-12-21 2015-12-03 Janssen R&D Ireland Antibacterial compounds
US9428474B2 (en) * 2012-12-21 2016-08-30 Janssen Sciences Ireland Uc Antibacterial compounds
US9951032B2 (en) * 2012-12-21 2018-04-24 Janssen Sciences Ireland Uc Antibacterial compounds
EP2945625A4 (en) * 2013-01-15 2016-09-14 Kineta Inc Anti-viral compounds

Also Published As

Publication number Publication date
MY7500001A (en) 1975-12-31
DE2003841B2 (en) 1973-09-06
BE744970A (en) 1970-07-27
FR2034500B1 (en) 1974-06-14
DE2003841C3 (en) 1974-04-11
FR2034500A1 (en) 1970-12-11
CY777A (en) 1975-03-01
DE2003841A1 (en) 1970-07-30

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee