GB1292094A - A phenylglycine derivative - Google Patents

A phenylglycine derivative

Info

Publication number
GB1292094A
GB1292094A GB20216/71A GB2021671A GB1292094A GB 1292094 A GB1292094 A GB 1292094A GB 20216/71 A GB20216/71 A GB 20216/71A GB 2021671 A GB2021671 A GB 2021671A GB 1292094 A GB1292094 A GB 1292094A
Authority
GB
United Kingdom
Prior art keywords
phenylglycinate
methyl
group
aspartyl
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20216/71A
Inventor
Georges Jolles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB1292094A publication Critical patent/GB1292094A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1292094 Methyl - L - aspartyl - L - α - phenylglycinate RHONE-POULENC SA 19 April 1971 [22 Jan 1970] 20216/71 Heading C2C The invention comprises methyl-L-aspartyl- L-α-phenylglycinate of the formula and acid addition and metal salts thereof. They may be prepared by reacting methyl L-α- phenylglycinate, or an addition salt thereof, with a derivative of L-aspartic acid of the general formula wherein Z represents a group protecting the amino radical, B represents a benzyl or t.-butyl radical, and A represents a hydrogen atom, a 2,4,5 - trichlorophenyl or p - nitrophenyl group or an alkoxy carbonyl group containing 2 to 7 carbon atoms, and removing from the resulting intermediate the protecting groups Z and B. The group Z may be trityl, p-nitrobenzyloxycarbonyl, p - bromobenzyloxycarbonyl or benzyloxycarbonyl or a C 2 to C 7 alkoxycarbonyl group. The methyl-L-aspartyl-L-α- phenylglycinate or its non-toxic acid addition salts may be used as sweetening agents.
GB20216/71A 1970-01-22 1971-04-19 A phenylglycine derivative Expired GB1292094A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7002317A FR2077486A1 (en) 1970-01-22 1970-01-22

Publications (1)

Publication Number Publication Date
GB1292094A true GB1292094A (en) 1972-10-11

Family

ID=9049467

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20216/71A Expired GB1292094A (en) 1970-01-22 1971-04-19 A phenylglycine derivative

Country Status (6)

Country Link
BE (1) BE761870A (en)
CH (1) CH518907A (en)
DE (1) DE2102988A1 (en)
FR (1) FR2077486A1 (en)
GB (1) GB1292094A (en)
NL (1) NL7100524A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941425B1 (en) * 1970-10-26 1974-11-08
GB1431057A (en) * 1972-03-30 1976-04-07 Gen Foods Corp Sweetining compositions
CA1028197A (en) * 1973-04-02 1978-03-21 Jeffrey H. Berg Concentrated liquid low calorie sweetener

Also Published As

Publication number Publication date
NL7100524A (en) 1971-07-26
BE761870A (en) 1971-07-22
CH518907A (en) 1972-02-15
DE2102988A1 (en) 1971-07-29
FR2077486A1 (en) 1971-10-29

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees