GB1283804A - A process for the manufacture of amino acids and derivatives thereof - Google Patents

A process for the manufacture of amino acids and derivatives thereof

Info

Publication number
GB1283804A
GB1283804A GB22808/70A GB2280870A GB1283804A GB 1283804 A GB1283804 A GB 1283804A GB 22808/70 A GB22808/70 A GB 22808/70A GB 2280870 A GB2280870 A GB 2280870A GB 1283804 A GB1283804 A GB 1283804A
Authority
GB
United Kingdom
Prior art keywords
alkyl
represents hydrogen
lower alkyl
hydroxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22808/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1283804A publication Critical patent/GB1283804A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1283804 3,4 - Dihydroxyphenylalanine derivatives F HOFFMANN-LA ROCHE & CO AG 12 May 1970 [14 May 1969] 22808/70 Heading C2C Compounds of Formula I in which R 1 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino, n stands for 1, 2 or 3, R 2 represents hydrogen or lower alkyl, R 3 represents hydroxy or optionally mono- or di-lower alkyl-substituted amino, R 4 represents hydrogen, lower alkyl, lower alkanoyl or aroyl and R 5 represents hydrogen or lower alkyl, "lower" denoting groups containing up to 6 carbon atoms, and salts thereof, which process comprises subjecting a compound of the general Formula II wherein one of the substituents R 6 and R 7 is hydroxy and the other substituent is lower alkanoyl, aroyl or carboxy, or a salt of such a compound to an oxidative rearrangement and saponifying the carboxylic acid ester obtained and, in any desired sequence, hydrolysing the product obtained if desired, resolving a racemate obtained into its optically active forms, if desired, and converting a product obtained into a salt if desired. Pharmaceutical compositions in conventional forms and having hypotensive and anti- Parkison activity comprise a novel compound of Formula I above, i.e. one in which n is 1 and R 1 is halogen or C 1-6 alkyl provided that R 2 is alkyl when R 1 is in the 2-position and R 2 is alkyl when R 1 is alkyl, and a carrier or diluent. Reference has been directed by the Comptroller to Specification 1,023,204.
GB22808/70A 1969-05-14 1970-05-12 A process for the manufacture of amino acids and derivatives thereof Expired GB1283804A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH735269A CH521313A (en) 1969-05-14 1969-05-14 Process for the preparation of phenylalamine derivatives

Publications (1)

Publication Number Publication Date
GB1283804A true GB1283804A (en) 1972-08-02

Family

ID=4323785

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22808/70A Expired GB1283804A (en) 1969-05-14 1970-05-12 A process for the manufacture of amino acids and derivatives thereof

Country Status (13)

Country Link
JP (1) JPS5220470B1 (en)
AT (1) AT300768B (en)
BE (1) BE750209A (en)
CH (1) CH521313A (en)
ES (1) ES379619A1 (en)
FR (1) FR2051524B1 (en)
GB (1) GB1283804A (en)
IE (1) IE34145B1 (en)
IL (1) IL34505A (en)
NL (1) NL144592B (en)
NO (1) NO127534B (en)
RO (1) RO58401A (en)
SU (1) SU376935A3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452922A2 (en) * 1979-04-02 1980-10-31 Panoz Donald Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression
CH647676A5 (en) * 1978-12-22 1985-02-15 Donald E Panoz ORAL, PROGRAM RELEASED GALENIC FORMS AND METHODS OF PREPARING THE SAME.
JPS5596436A (en) * 1979-01-19 1980-07-22 Nippon Hodo Co Ltd Method of preserving soil sample
JPS6033001U (en) * 1983-08-12 1985-03-06 株式会社　長崎機器製作所 Upper residual air removal device for flexible container containers
JPS618501U (en) * 1984-06-19 1986-01-18 雪印乳業株式会社 Deaeration bag packaging equipment for powder, etc.

Also Published As

Publication number Publication date
IE34145L (en) 1970-11-14
IE34145B1 (en) 1975-02-19
DE2023461A1 (en) 1970-11-19
ES379619A1 (en) 1973-01-16
NL144592B (en) 1975-01-15
IL34505A0 (en) 1970-07-19
JPS5220470B1 (en) 1977-06-03
RO58401A (en) 1975-09-15
NL7006842A (en) 1970-11-17
FR2051524A1 (en) 1971-04-09
SU376935A3 (en) 1973-04-05
DE2023461B2 (en) 1977-06-08
AT300768B (en) 1972-08-10
FR2051524B1 (en) 1974-03-22
NO127534B (en) 1973-07-09
BE750209A (en) 1970-11-12
CH521313A (en) 1972-04-15
IL34505A (en) 1974-10-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee