GB1277759A - Gona-3,5-dienes - Google Patents
Gona-3,5-dienesInfo
- Publication number
- GB1277759A GB1277759A GB3816969A GB3816969A GB1277759A GB 1277759 A GB1277759 A GB 1277759A GB 3816969 A GB3816969 A GB 3816969A GB 3816969 A GB3816969 A GB 3816969A GB 1277759 A GB1277759 A GB 1277759A
- Authority
- GB
- United Kingdom
- Prior art keywords
- enol
- ones
- steroids
- alkyl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47F—SPECIAL FURNITURE, FITTINGS, OR ACCESSORIES FOR SHOPS, STOREHOUSES, BARS, RESTAURANTS OR THE LIKE; PAYING COUNTERS
- A47F3/00—Show cases or show cabinets
- A47F3/12—Clamps or other devices for supporting, fastening, or connecting glass plates, panels or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
1277759 3-Cyclopentyloxy-#<SP>3</SP>'<SP>5</SP>-storoids AMERICAN HOME PRODUCTS CORP 30 July 1969 [15 Oct 1968 21 April 1969 (2)] 38169/69 Heading C2U Novel steroids of the formula (wherein R is C 2-20 alkyl; R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> are each H or CH 3 ; and R<SP>6</SP> is H or COR<SP>5</SP> where R<SP>5</SP> is C 1-10 alkyl, C 3-6 cycloalkyl or monocyclic aryl- C 1-6 alkyl) are prepared (1) by enol acylation of the corresponding 17#-hydroxy-#<SP>4</SP>-3-ones followed by treatment of the products with cyclopentanol in presence of an acid catalyst to give the required steroids wherein R<SP>6</SP> is COR<SP>5</SP>; or (2) by enol etherification of the corresponding 17#-acyloxy-#<SP>4</SP>-3-ones using cyclopentanol, cyclopentyl orthoformate or a dicyclopentyl ketal of a ketone in the presence of an acid catalyst, or by a similar process using as the starting material a 3-enol ester or -enol ether; or (3) by ethynylation of the corresponding 17-ones, prepared in turn from the corresponding #<SP>3,5</SP>-3-enol esters, these being prepared by acylation of the #<SP>4</SP>-3-ones. The products of these processes may be d-steroids or these in admixture with lsteroids e.g. racemates. The novel steroids are progestational agents and may be made up into pharmaceutical compositions with suitable carriers. They may be used, among other things, for preventing conception. Specifications 1,041,278, 1,191,347, 1,103,205 and 1,277,760 are referred to. Reference has been directed by the Comptroller to Specification 1,041,278.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76780968A | 1968-10-15 | 1968-10-15 | |
US81812669A | 1969-04-21 | 1969-04-21 | |
US81811969A | 1969-04-21 | 1969-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1277759A true GB1277759A (en) | 1972-06-14 |
Family
ID=27419641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3816969A Expired GB1277759A (en) | 1968-10-15 | 1969-07-30 | Gona-3,5-dienes |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE1966504A1 (en) |
GB (1) | GB1277759A (en) |
-
1969
- 1969-07-30 GB GB3816969A patent/GB1277759A/en not_active Expired
- 1969-10-15 DE DE19691966504 patent/DE1966504A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE1966504A1 (en) | 1973-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |