GB1263481A - Sample injector for use in liquid chromatography - Google Patents

Sample injector for use in liquid chromatography

Info

Publication number
GB1263481A
GB1263481A GB05815/69A GB1581569A GB1263481A GB 1263481 A GB1263481 A GB 1263481A GB 05815/69 A GB05815/69 A GB 05815/69A GB 1581569 A GB1581569 A GB 1581569A GB 1263481 A GB1263481 A GB 1263481A
Authority
GB
United Kingdom
Prior art keywords
sample
reservoirs
pump
liquid chromatography
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB05815/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of GB1263481A publication Critical patent/GB1263481A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel

Landscapes

  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Multiple-Way Valves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

1,263,481. Automatic liquid chromatography apparatus. BECKMAN INSTRUMENTS Inc. 26 March, 1969 [2 April, 1968], No. 15815/69. Heading B1X. A high pressure automatic liquid chromatography system suitable for amino acid analysis comprises a sequentially stepped rotatable sample-carrying table 25 and two independent ion-exchange columns 10, 11. As shown, a sample is being drawn into sample valve 23 under the influence of pump 26 and eluent from any of reservoirs 14-17 is passing by pump 12 through a by-pass line in valve 23 into and through long column 10 thereby eluting a previously delivered sample into reactor-detector 22, while at the same time a sample previously drawn up into sample valve 24 is being eluted into short column 11 by means of eluent from any of reservoirs 15-18 passed by pump 13. At the appropriate points in time, table 25 is stepped and valves 19, 20, 21, 23, 24 and 27 switched by means of a programmer to reverse the functions of the two column systems. The sample reservoirs into which the sample is loaded suitably comprises a helically-wound tube mounted around a spool, in which tube the sample is held by means of surface tension (see Fig. 2, not shown). Alternatively, spirally-wound sample reservoirs (see Figs. 6a, b, not shown) may be used. The details of valves 23, 24 are the subject of Specification 1,263,483.
GB05815/69A 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography Expired GB1263481A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71816668A 1968-04-02 1968-04-02

Publications (1)

Publication Number Publication Date
GB1263481A true GB1263481A (en) 1972-02-09

Family

ID=24885079

Family Applications (3)

Application Number Title Priority Date Filing Date
GB26916/70A Expired GB1263483A (en) 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography
GB26915/70A Expired GB1263482A (en) 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography
GB05815/69A Expired GB1263481A (en) 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB26916/70A Expired GB1263483A (en) 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography
GB26915/70A Expired GB1263482A (en) 1968-04-02 1969-03-26 Sample injector for use in liquid chromatography

Country Status (4)

Country Link
US (1) US3504799A (en)
JP (1) JPS5020877B1 (en)
DE (1) DE1915113A1 (en)
GB (3) GB1263483A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355709A1 (en) * 2000-12-28 2003-10-29 Cohesive Technologies Inc. Multi column chromatography system
WO2008140374A1 (en) * 2007-05-15 2008-11-20 Ge Healthcare Bio-Sciences Ab Flow distributing valve
US9404900B2 (en) * 2012-12-21 2016-08-02 Thermo Finnigan Llc System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1441462A (en) * 1973-02-14 1976-06-30 Univ Edinburgh University Cour Method and apapratus for liquid chromotography
US3926809A (en) * 1973-10-10 1975-12-16 Roosevelt J Jones Multi-column fractionator
US3830369A (en) * 1973-12-11 1974-08-20 E Pfadenhauer High pressure gradient chamber for liquid chromatography
JPS5630500B2 (en) * 1974-02-27 1981-07-15
DE2418509C3 (en) * 1974-04-17 1978-04-27 Sartorius-Membranfilter Gmbh, 3400 Goettingen Device for the semi-automatic simultaneous column chromatographic separation of a large number of sample solutions
JPS5330390A (en) * 1976-09-02 1978-03-22 Nippon Bunko Kogyo Kk Liquid chromatograph
JPS54114991U (en) * 1978-02-01 1979-08-13
JPS55144543A (en) * 1979-04-28 1980-11-11 Japan Spectroscopic Co Device for introducing trace specimen in chromaograph separator
US4444066A (en) * 1981-06-29 1984-04-24 Beckman Instruments, Inc. High pressure sample injector valve
US4926702A (en) * 1987-09-18 1990-05-22 Beckman Instruments, Inc. Sample presence detector for automatic sample injector
US4957008A (en) * 1988-12-28 1990-09-18 Coulter Electronics, Inc. Fluid sampling and transfer valve assembly
US5443734A (en) * 1990-03-05 1995-08-22 Applied Separations, Inc. Programmable solid phase extraction and elution device
US6672336B2 (en) 2001-11-28 2004-01-06 Rheodyne, Lp Dual random access, three-way rotary valve apparatus
US7588683B2 (en) * 2005-08-03 2009-09-15 Agilent Technologies, Inc. Column for liquid chromatography with adjustable compression
JP2011141120A (en) * 2008-10-07 2011-07-21 Arkray Inc Liquid chromatography device and liquid chromatography
JP6035603B2 (en) 2012-12-19 2016-11-30 株式会社日立ハイテクノロジーズ Sample introduction device
CN108351330B (en) * 2015-10-20 2021-03-09 沃特世科技公司 Systems, methods, and apparatus for cross-flow sample chromatography
WO2017070156A1 (en) * 2015-10-20 2017-04-27 Waters Technologies Corporation Systems, methods and devices for decreasing solubility problems in chromatography
US10823712B2 (en) 2017-01-06 2020-11-03 Waters Technologies Corporation Modifier stream elution of trap column for multidimensional compressible fluid-based chromatography
JP6895819B2 (en) * 2017-06-26 2021-06-30 アークレイ株式会社 Liquid chromatography equipment
US10527192B2 (en) 2018-02-15 2020-01-07 Talis Biomedical Corporation Rotary valve
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CN111879955B (en) * 2020-07-30 2022-04-19 中国科学院植物研究所 Automatic sample injector

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249403A (en) * 1962-11-02 1966-05-03 Beckman Instruments Inc Liquid sample reactor and evolved gas detector
US3223123A (en) * 1963-05-27 1965-12-14 Sun Oil Co Multifunction valve for chromatography
DE1598205B1 (en) * 1964-04-13 1971-05-19 Ceskoslovenska Akademie Ved DEVICE FOR CHROMATOGRAPHY OF AMINO ACIDS AND MIXTURES CONTAINING THE SAME

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355709A1 (en) * 2000-12-28 2003-10-29 Cohesive Technologies Inc. Multi column chromatography system
EP1355709A4 (en) * 2000-12-28 2008-12-24 Cohesive Tech Inc Multi column chromatography system
US7594999B2 (en) 2000-12-28 2009-09-29 Cohesive Technologies Inc. Multi column chromatography system
EP2362215A1 (en) * 2000-12-28 2011-08-31 Cohesive Technologies Inc. Multi column chromatography system
WO2008140374A1 (en) * 2007-05-15 2008-11-20 Ge Healthcare Bio-Sciences Ab Flow distributing valve
US8225817B2 (en) 2007-05-15 2012-07-24 Ge Healthcare Bio-Sciences Ab Flow distributing valve
AU2008251098B2 (en) * 2007-05-15 2013-11-21 Ge Healthcare Bio-Sciences Ab Flow distributing valve
US9404900B2 (en) * 2012-12-21 2016-08-02 Thermo Finnigan Llc System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis
US10753915B2 (en) 2012-12-21 2020-08-25 Thermo Finnigan Llc Methods for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis

Also Published As

Publication number Publication date
GB1263483A (en) 1972-02-09
JPS5020877B1 (en) 1975-07-18
DE1915113A1 (en) 1969-10-23
GB1263482A (en) 1972-02-09
US3504799A (en) 1970-04-07

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