GB1263180A - A process for the manufacture of indane derivatives - Google Patents

A process for the manufacture of indane derivatives

Info

Publication number
GB1263180A
GB1263180A GB48630/70A GB4863070A GB1263180A GB 1263180 A GB1263180 A GB 1263180A GB 48630/70 A GB48630/70 A GB 48630/70A GB 4863070 A GB4863070 A GB 4863070A GB 1263180 A GB1263180 A GB 1263180A
Authority
GB
United Kingdom
Prior art keywords
group
formula
compounds
ester
nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48630/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1263180A publication Critical patent/GB1263180A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1,263,180. Indane derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 18 Nov., 1969 [19 Nov., 1969], No. 48630/70. Divided out of 1,263,179. Heading C2C. The invention comprises compounds of the formula where D is a group of the formula where R<SP>1</SP> is acetyl which may be ketalized, 1- hydroxy ethyl or 1-acyloxyethyl, X is C 1-8 alkylidene and R<SP>2</SP> is hydroxy, C 1-4 alkoxy or halogen. The compounds are prepared from compounds of the formula where D<SP>1</SP> is a group of Formula V or of the formula where R<SP>3</SP> is a ketalized acetyl or 1-hydroxyethyl or 1-acyloxyethyl group by esterification, reacting the ester with an alkylidene phosphorane under the conditions of a Wittig reaction and (a) if desired saponifying the ester group and/or cleaving the ketal group or (b) saponifying the ester group, transforming the acid to an acid halide group and if desired cleaving the ketal group. The compound of the invention may be cyclized to compounds of the formula where R is H or C 1-7 alkyl.
GB48630/70A 1968-11-19 1969-11-18 A process for the manufacture of indane derivatives Expired GB1263180A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1722468A CH527147A (en) 1968-11-19 1968-11-19 Process for the production of indane derivatives

Publications (1)

Publication Number Publication Date
GB1263180A true GB1263180A (en) 1972-02-09

Family

ID=4423735

Family Applications (2)

Application Number Title Priority Date Filing Date
GB48630/70A Expired GB1263180A (en) 1968-11-19 1969-11-18 A process for the manufacture of indane derivatives
GB56315/69A Expired GB1263179A (en) 1968-11-19 1969-11-18 A process for the manufacture of indane derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB56315/69A Expired GB1263179A (en) 1968-11-19 1969-11-18 A process for the manufacture of indane derivatives

Country Status (7)

Country Link
JP (1) JPS5011382B1 (en)
BE (1) BE741826A (en)
CH (1) CH527147A (en)
DE (1) DE1957992A1 (en)
FR (1) FR2023617A1 (en)
GB (2) GB1263180A (en)
NL (1) NL6917379A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH585171A5 (en) * 1972-08-31 1977-02-28 Hoffmann La Roche
JPS5538316A (en) * 1978-09-08 1980-03-17 Takeda Chem Ind Ltd Intermediate for synthesis of steroid and its preparation

Also Published As

Publication number Publication date
JPS5011382B1 (en) 1975-04-30
CH527147A (en) 1972-08-31
FR2023617A1 (en) 1970-08-21
BE741826A (en) 1970-05-19
DE1957992A1 (en) 1970-06-18
GB1263179A (en) 1972-02-09
NL6917379A (en) 1970-05-21

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