GB1257190A - - Google Patents
Info
- Publication number
- GB1257190A GB1257190A GB1257190DA GB1257190A GB 1257190 A GB1257190 A GB 1257190A GB 1257190D A GB1257190D A GB 1257190DA GB 1257190 A GB1257190 A GB 1257190A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- prepared
- acid
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
1,257,190. Anilino-acetic acids. J. R. GEIGY A.G. 19 Dec., 1968 [20 Dec., 1967 (2)], No. 60497/68. Heading C2C. Compounds of Formula I wherein R 1 is Cl, Br, F, CF 3 , C 1-4 alkyl or C 1-4 alkoxy, R 2 and R 3 are each H, Cl, Br, F or C 1-4 alkyl and R 4 is H, Cl, Br, F; C 1-4 alkyl or C 1-4 alkoxy and at least one of R 1 , R 2 and' R 3 is other than H and is ortho to the NH group, and salts thereof, are' prepared from the isotins of Formula IV either by reduction with hydrazine or semicarbazide and an alkali metal hydroxide or alcoholate according to the Wolff - Kishner method or by hydrolysis to a glyoxylic acid V which is then reduced by the same method and in each case optionally converting thesalt obtained into the free acid or other salts. Compounds of Formula IV above are prepared by cyclization of the compound of Formula III / prepared by reaction of oxalic acid chloride and the corresponding N-arylanaline derivative, some of which are obtained by decarboxylation of the corresponding ortho-carboxylic acids obtained by copper/KOH fusion of an orthochlorobenzoic acid and a substituted analine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1789267A CH487840A (en) | 1967-12-20 | 1967-12-20 | Process for the preparation of substituted phenylacetic acids |
| CH1789367A CH485667A (en) | 1967-12-20 | 1967-12-20 | Process for the preparation of substituted phenylacetic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1257190A true GB1257190A (en) | 1971-12-15 |
Family
ID=25720227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1257190D Expired GB1257190A (en) | 1967-12-20 | 1968-12-19 |
Country Status (16)
| Country | Link |
|---|---|
| JP (4) | JPS5220469B1 (en) |
| AT (1) | AT284823B (en) |
| BE (1) | BE725793A (en) |
| CS (2) | CS151496B2 (en) |
| DE (1) | DE1815802A1 (en) |
| DK (1) | DK125461B (en) |
| ES (1) | ES361666A1 (en) |
| FI (1) | FI49600C (en) |
| FR (1) | FR1595382A (en) |
| GB (1) | GB1257190A (en) |
| IE (1) | IE32591B1 (en) |
| IL (1) | IL31296A (en) |
| NL (1) | NL6817965A (en) |
| NO (1) | NO125724B (en) |
| SE (1) | SE366296B (en) |
| YU (1) | YU32986B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001003684A2 (en) * | 1999-07-08 | 2001-01-18 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| US8362294B2 (en) | 2006-06-26 | 2013-01-29 | Novartis Ag | Phenylacetic acid derivatives |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS549240A (en) * | 1977-06-23 | 1979-01-24 | Asahi Chem Ind Co Ltd | New derivative of phenylglycolic acid, its preparation and analgesic and antiinflammatory agent contining it as effective component |
| IT1112024B (en) * | 1979-02-23 | 1986-01-13 | Alcar Srl | PROCESS FOR THE PREPARATION OF O. (2,6-DICHLOROANILINE) -PHENYLACETIC ACID |
| LU83138A1 (en) * | 1981-02-16 | 1981-09-11 | T Eckert | TOPICAL PHARMACEUTICAL PREPARATIONS, CONTAINING SALTS OF ALKANCARBONIC ACIDS AND NEW CARBONIC ACID SALTS AND METHOD FOR THE PRODUCTION THEREOF |
| AT370721B (en) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE |
| CH655507B (en) * | 1983-01-12 | 1986-04-30 | ||
| JPS6341143U (en) * | 1986-09-02 | 1988-03-17 | ||
| US5160487A (en) * | 1990-09-04 | 1992-11-03 | Hitachi Chemical Company, Ltd. | Electrophotographic member |
| FR2878522B1 (en) | 2004-12-01 | 2008-04-18 | Merck Sante Soc Par Actions Si | NEW SPECIFIC INHIBITORS OF CASPAS-10 |
| ES2472545T3 (en) | 2006-07-25 | 2014-07-01 | Techfields Biochem Co. Ltd | Water soluble diclofenac prodrugs with positive charge and with a very fast skin penetration rate |
| CN114539086B (en) | 2022-02-25 | 2023-10-03 | 复旦大学 | Synthesis method of diclofenac sodium |
| CN114516813B (en) | 2022-02-25 | 2024-05-28 | 复旦大学 | Continuous flow preparation method of diclofenac sodium |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5220469A (en) * | 1975-08-08 | 1977-02-16 | Mitsui Toatsu Chem Inc | Method for grading granule |
| JPS5851859B2 (en) * | 1978-08-11 | 1983-11-18 | 株式会社日立製作所 | Form sending device |
-
1968
- 1968-12-13 FI FI683591A patent/FI49600C/en active
- 1968-12-13 NO NO5013/68A patent/NO125724B/no unknown
- 1968-12-13 NL NL6817965A patent/NL6817965A/xx unknown
- 1968-12-13 SE SE17151/68A patent/SE366296B/xx unknown
- 1968-12-13 DK DK612768AA patent/DK125461B/en not_active IP Right Cessation
- 1968-12-17 YU YU2983/68A patent/YU32986B/en unknown
- 1968-12-19 FR FR1595382D patent/FR1595382A/fr not_active Expired
- 1968-12-19 ES ES361666A patent/ES361666A1/en not_active Expired
- 1968-12-19 IE IE1536/68A patent/IE32591B1/en unknown
- 1968-12-19 GB GB1257190D patent/GB1257190A/en not_active Expired
- 1968-12-19 DE DE19681815802 patent/DE1815802A1/en active Pending
- 1968-12-19 AT AT1236868A patent/AT284823B/en not_active IP Right Cessation
- 1968-12-19 CS CS5436*[A patent/CS151496B2/cs unknown
- 1968-12-19 IL IL31296A patent/IL31296A/en unknown
- 1968-12-19 CS CS8634A patent/CS151495B2/cs unknown
- 1968-12-19 JP JP43092731A patent/JPS5220469B1/ja active Pending
- 1968-12-20 BE BE725793D patent/BE725793A/xx not_active IP Right Cessation
-
1978
- 1978-06-07 JP JP6871878A patent/JPS5526131B1/ja active Pending
- 1978-10-31 JP JP13440778A patent/JPS5635664B1/ja active Pending
-
1979
- 1979-05-02 JP JP5465379A patent/JPS5526132B1/ja active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552077B2 (en) | 1996-02-20 | 2003-04-22 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| WO2001003684A2 (en) * | 1999-07-08 | 2001-01-18 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| WO2001003684A3 (en) * | 1999-07-08 | 2002-06-06 | Exocell Inc | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
| US8362294B2 (en) | 2006-06-26 | 2013-01-29 | Novartis Ag | Phenylacetic acid derivatives |
| US8586782B2 (en) | 2006-06-26 | 2013-11-19 | Novartis Ag | Phenylacetic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FI49600C (en) | 1975-08-11 |
| IL31296A0 (en) | 1969-02-27 |
| JPS5526131B1 (en) | 1980-07-11 |
| CS151495B2 (en) | 1973-10-19 |
| FI49600B (en) | 1975-04-30 |
| IE32591L (en) | 1969-06-20 |
| YU298368A (en) | 1975-06-30 |
| DK125461B (en) | 1973-02-26 |
| NL6817965A (en) | 1969-06-24 |
| IL31296A (en) | 1972-06-28 |
| SE366296B (en) | 1974-04-22 |
| YU32986B (en) | 1975-12-31 |
| JPS5220469B1 (en) | 1977-06-03 |
| IE32591B1 (en) | 1973-09-19 |
| DE1815802A1 (en) | 1969-07-10 |
| ES361666A1 (en) | 1970-11-16 |
| CS151496B2 (en) | 1973-10-19 |
| BE725793A (en) | 1969-06-20 |
| JPS5635664B1 (en) | 1981-08-19 |
| AT284823B (en) | 1970-09-25 |
| JPS5526132B1 (en) | 1980-07-11 |
| FR1595382A (en) | 1970-06-08 |
| NO125724B (en) | 1972-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| PCNP | Patent ceased through non-payment of renewal fee |