GB1251977A - - Google Patents
Info
- Publication number
- GB1251977A GB1251977A GB1251977DA GB1251977A GB 1251977 A GB1251977 A GB 1251977A GB 1251977D A GB1251977D A GB 1251977DA GB 1251977 A GB1251977 A GB 1251977A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- ursolic acid
- formula
- esterification
- aug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,251,977. Ursolic acid derivatives. RAVIZZA S.A. 1 Aug., 1969 [8 Aug., 1968], No. 38032/68. Heading C2C. Novel compounds of formula (wherein R is a saturated or unsaturated, linear or branched aliphatic hydrocarbon chain comprising from 3 to 20 carbon atoms and having no more than 2 carbon atoms in each of any branches, and R 1 is -CH 2 R, where R is as just defined, the two groups denoted by the symbol R being the same or different) are prepared from ursolic acid by acylation of the 3-hydroxy group and esterification of the 17-carboxy group, these steps being performed in either order. The 17-esterification may be performed either directly using a compound of formula R 1 X (X = halo), or indirectly via a 17-halocarbonyl compound which is reacted with a compound R 1 OH. Crotyl ursolate is prepared by reacting ursolic acid with crotyl bromide. Compounds of the above formula are stated to possess antiphlogistic and anti-ulcer activity, and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3803268 | 1968-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1251977A true GB1251977A (en) | 1971-11-03 |
Family
ID=10400725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1251977D Expired GB1251977A (en) | 1968-08-08 | 1968-08-08 |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1251977A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752606A (en) * | 1982-04-27 | 1988-06-21 | 501 Noristan Limited | Pharmaceutical compositions and preparations thereof |
-
1968
- 1968-08-08 GB GB1251977D patent/GB1251977A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752606A (en) * | 1982-04-27 | 1988-06-21 | 501 Noristan Limited | Pharmaceutical compositions and preparations thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |