GB1229651A - - Google Patents
Info
- Publication number
- GB1229651A GB1229651A GB1229651DA GB1229651A GB 1229651 A GB1229651 A GB 1229651A GB 1229651D A GB1229651D A GB 1229651DA GB 1229651 A GB1229651 A GB 1229651A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formulμ
- isoindoles
- lialh
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,229,651. Isoindoles and isoindolines. AMERICAN HOME PRODUCTS CORP. 14 March, 1968 [14 March, 1967], No. 12411/68. Heading C2C. The invention comprises (subject to disclaimers with respect to Specifications 1,097,168,1,144,060 and 1,162,835) (1) compounds of formulµ and their addition salts with pharmaceutically acceptable acids, (2) a process for making the isoindoles by reacting a compound of formula with LiAlH 4 , and (3) processes for making the isoindolines by (a) reducing a phthalimidine of formula with LiAlH 4 , (b) (when R<SP>4</SP> = H and n= 3) catalytically reducing the corresponding isoindoles, or (c) (when R<SP>4</SP> = tosyl and n = 2 or 3) reducing a compound of formula where p = 2 or 3, with LiAlH 4 . In these formulµ, R<SP>1</SP> is C 1-6 , alkyl, Ph (possibly substituted by CF 3 , 1-2 halogen atoms or 1-2 C 1-6 alkyl or alkoxy groups), Ph-C 1-6 alkyl, thienyl, pyridyl, furyl or 5,6,7,8 - tetrahydro - 2 - naphthyl, R<SP>2</SP> are both H, halogen or C 1-6 alkyl or akoxy, or R<SP>2</SP> is H and R<SP>3</SP> is NH 2 , C 1-6 -alkyl NH, halogen or C 1-6 alkyl or alkoxy, R<SP>4</SP> is H or tosyl, R<SP>5</SP> is C 1-6 alkyl, m is 2 or 3, and n is 2-7. Therapeutic compositions for oral or parenteral administration comprise compounds of the first two formulµ above, which have anorexiant and antidepressant activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62291767A | 1967-03-14 | 1967-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1229651A true GB1229651A (en) | 1971-04-28 |
Family
ID=24496042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1229651D Expired GB1229651A (en) | 1967-03-14 | 1968-03-14 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS4939677B1 (en) |
DE (1) | DE1670041A1 (en) |
FR (1) | FR1580180A (en) |
GB (1) | GB1229651A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005061513A1 (en) * | 2003-12-24 | 2005-07-07 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598194B2 (en) | 2006-09-28 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8604034B2 (en) | 2010-02-08 | 2013-12-10 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-α]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus (RSV) infections |
US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5340375U (en) * | 1976-09-06 | 1978-04-07 | ||
JPS5340376U (en) * | 1976-09-06 | 1978-04-07 | ||
FR2630113B2 (en) * | 1987-08-07 | 1990-07-20 | Synthelabo | ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2634204B2 (en) * | 1987-08-07 | 1990-09-07 | Synthelabo | ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINS DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2619110B1 (en) * | 1987-08-07 | 1989-11-17 | Synthelabo | ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2625504B2 (en) * | 1987-08-07 | 1990-05-04 | Synthelabo | ((BENZOYL-1 PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2630114B2 (en) * | 1987-08-07 | 1990-07-20 | Synthelabo | (PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2634205B2 (en) * | 1987-08-07 | 1990-09-07 | Synthelabo | ME THYL-4 ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
EP0306375A1 (en) * | 1987-08-07 | 1989-03-08 | Synthelabo | 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy |
IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
US6025367A (en) * | 1996-06-25 | 2000-02-15 | Smithkline Beecham Plc | Sulfonamide derivatives as 5HT7 receptor antagonists |
-
1968
- 1968-03-14 FR FR1580180D patent/FR1580180A/fr not_active Expired
- 1968-03-14 JP JP1625068A patent/JPS4939677B1/ja active Pending
- 1968-03-14 GB GB1229651D patent/GB1229651A/en not_active Expired
- 1968-03-14 DE DE19681670041 patent/DE1670041A1/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005061513A1 (en) * | 2003-12-24 | 2005-07-07 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598193B2 (en) | 2003-12-24 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598194B2 (en) | 2006-09-28 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US9675694B2 (en) | 2006-09-28 | 2017-06-13 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8604034B2 (en) | 2010-02-08 | 2013-12-10 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-α]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus (RSV) infections |
US9163029B2 (en) | 2010-02-08 | 2015-10-20 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-a]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections |
US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
Also Published As
Publication number | Publication date |
---|---|
DE1670041A1 (en) | 1972-03-02 |
FR1580180A (en) | 1969-09-05 |
JPS4939677B1 (en) | 1974-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1229651A (en) | ||
GB1380129A (en) | Benzofuran derivatives and preparation thereof | |
GB1298313A (en) | Quinazoline derivatives | |
GB1209558A (en) | Derivatives of 5-cinnamoyl benzofuran and process for their preparation | |
GB1229653A (en) | ||
GB1367785A (en) | 2-substituted adenosine derivatives and the production thereof | |
GB1188154A (en) | New Pyridine Derivatives and process for their preparation | |
GB1169945A (en) | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives | |
GB1252847A (en) | ||
GB1256723A (en) | ||
GB1227006A (en) | ||
GB1322024A (en) | Benzimidazoisoindoles the preparation thereof and compositions containing the same | |
GB1186062A (en) | Benzonaphthyridine Derivatives | |
GB1184826A (en) | Substituted Aryloxy Hydroxy Amines | |
GB1229509A (en) | ||
GB1155195A (en) | Improvements in or relating to Indole Derivatives and the manufacture thereof | |
GB1311004A (en) | Dibenzocycloheptenes | |
GB1139146A (en) | Benzofuran derivatives and processes for preparing the same | |
GB1133080A (en) | Improvements in or relating to derivatives of nitrofuran | |
GB1243955A (en) | Novel n-substituted amines and their process of preparation | |
GB1280553A (en) | Benzophenonimine derivatives | |
GB1394409A (en) | Preparation of n-1-ethyl-2-pyrrolidylmethyl-2-methoxy-5- ethylsulphonyl-benzamide | |
GB1384523A (en) | Oxime derivatives and their preparation | |
GB1235957A (en) | Alkaloid derivative | |
GB1273399A (en) | Novel formamido-cycloalkane derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |