GB1223962A - Improvements in or relating to crystalline chlortetracycline bisulfate - Google Patents
Improvements in or relating to crystalline chlortetracycline bisulfateInfo
- Publication number
- GB1223962A GB1223962A GB1038869A GB1038869A GB1223962A GB 1223962 A GB1223962 A GB 1223962A GB 1038869 A GB1038869 A GB 1038869A GB 1038869 A GB1038869 A GB 1038869A GB 1223962 A GB1223962 A GB 1223962A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bisulphate
- chlortetracycline
- crystalline
- feb
- crystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,223,962. Preparing chlortetracycline bisulphate. DIAMOND SHAMROCK CORP. 26 Feb., 1969 [28 Feb., 1968], No. 10388/69. Heading C2A. Crystalline chlortetracycline bisulphate is prepared by slurrying chlortetracycline in tetrahydrofuran, adding sulphuric acid to the slurry to form a solution of the bisulphate, clarifying the solution, and crystallizing and recovering the required product. The sulphuric acid may be added as a mixture with further tetrahydrofuran. Crystallization may be initiated by seeding with crystals of chlortetracycline bisulphate or by addition of a non- solvent, e.g. C 1 to C 4 alkanols. The starting tetracycline is suitably prepared by treating the hydrochloride salt with alkali or nitrogenous base. A further yield of the bisulphate is obtained from the mother-liquor after crystallization by precipitation with a non- solvent.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70881568A | 1968-02-28 | 1968-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1223962A true GB1223962A (en) | 1971-03-03 |
Family
ID=24847292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1038869A Expired GB1223962A (en) | 1968-02-28 | 1969-02-26 | Improvements in or relating to crystalline chlortetracycline bisulfate |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE729040A (en) |
FR (1) | FR2002786A1 (en) |
GB (1) | GB1223962A (en) |
IT (1) | IT1053255B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103739514A (en) * | 2013-12-24 | 2014-04-23 | 福建省福抗药业股份有限公司 | Production method of chlortetracycline bisulfate |
CN106316794A (en) * | 2016-08-22 | 2017-01-11 | 浦城正大生化有限公司 | Method for recycling ethyl alcohol in chlortetracycline hydrochloride crystallization mother liquor |
-
1969
- 1969-02-26 GB GB1038869A patent/GB1223962A/en not_active Expired
- 1969-02-26 IT IT3528869A patent/IT1053255B/en active
- 1969-02-27 BE BE729040D patent/BE729040A/xx unknown
- 1969-02-27 FR FR6905088A patent/FR2002786A1/fr not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103739514A (en) * | 2013-12-24 | 2014-04-23 | 福建省福抗药业股份有限公司 | Production method of chlortetracycline bisulfate |
CN103739514B (en) * | 2013-12-24 | 2015-05-20 | 福建省福抗药业股份有限公司 | Production method of chlortetracycline bisulfate |
CN106316794A (en) * | 2016-08-22 | 2017-01-11 | 浦城正大生化有限公司 | Method for recycling ethyl alcohol in chlortetracycline hydrochloride crystallization mother liquor |
CN106316794B (en) * | 2016-08-22 | 2019-02-26 | 浦城正大生化有限公司 | The recovery method of ethyl alcohol in aureomycin hydrochloride crystalline mother solution |
Also Published As
Publication number | Publication date |
---|---|
FR2002786A1 (en) | 1969-10-31 |
IT1053255B (en) | 1981-08-31 |
BE729040A (en) | 1969-08-27 |
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