GB1223889A - Process for the preparation of aziridine derivatives - Google Patents

Process for the preparation of aziridine derivatives

Info

Publication number
GB1223889A
GB1223889A GB2579368A GB2579368A GB1223889A GB 1223889 A GB1223889 A GB 1223889A GB 2579368 A GB2579368 A GB 2579368A GB 2579368 A GB2579368 A GB 2579368A GB 1223889 A GB1223889 A GB 1223889A
Authority
GB
United Kingdom
Prior art keywords
acid addition
addition salts
azatricyclo
octane
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2579368A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1223889A publication Critical patent/GB1223889A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0231—Halogen-containing compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0245—Nitrogen containing compounds being derivatives of carboxylic or carbonic acids
    • B01J31/0247—Imides, amides or imidates (R-C=NR(OR))
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3412—Heterocyclic compounds having nitrogen in the ring having one nitrogen atom in the ring

Abstract

1,223,889. Aziridine derivatives. SHIONOGI & CO. Ltd. 30 May, 1968 [3 June, 1967], No. 25893/68. Heading C2C. The invention comprises compounds of the Formula (I) wherein X, Y and Z are the same or different and each represent a C 1-2 alkylene group or groups -CH=CH-, and the ring formed by X, Z and the three carbon atoms and the group Y may be substituted by a halogen atom, a nitro, amino, amido, alkyl, alkenyl, alkoxy, hydroxy, acyloxy, carboxyl or a mercapto group, and the ring defined by X, Z and the three carbon atoms may be condensed or bridged with a carbocyclic ring system but not so as to disturb the reaction of the molecule and the acid addition salts and quaternary ammonium salts thereof. They are prepared by reacting an unsaturated primary amine of the formula wherein X, Y and Z are as defined above with a halonium reagent, e.g. N-bromosuccinimide, sodium or t-butylhypochlorite, lead tetraacetate or mercuric oxide. The preparation of 5 - methyl - 1 - azatricyclo - (3.2.1.0<SP>2À7</SP>) octane, its organic acid addition salts and methiodide, of 1-azatricyclo-(3.2.1.0.<SP>2</SP>.<SP>7</SP>) octane, its organic acid addition salts, of 8a-methano-trans-perhydroaziridino - (1.2<SP>-b</SP>) isoquinoline, its picrate and flavianate and of 3-(exo)-ethyl-1-azatricyclo-(3.2.1.0<SP>2À7</SP>) octane and its acid addition salts, is exemplified. A list of starting materials is also given exemplifying each one of the substituents listed above.
GB2579368A 1967-06-03 1968-05-30 Process for the preparation of aziridine derivatives Expired GB1223889A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3564667 1967-06-03

Publications (1)

Publication Number Publication Date
GB1223889A true GB1223889A (en) 1971-03-03

Family

ID=12447624

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2579368A Expired GB1223889A (en) 1967-06-03 1968-05-30 Process for the preparation of aziridine derivatives

Country Status (5)

Country Link
CH (1) CH521367A (en)
DE (1) DE1770560A1 (en)
FR (1) FR1570308A (en)
GB (1) GB1223889A (en)
NL (1) NL6807827A (en)

Also Published As

Publication number Publication date
NL6807827A (en) 1968-12-04
CH521367A (en) 1972-04-15
DE1770560A1 (en) 1971-11-04
FR1570308A (en) 1969-06-06

Similar Documents

Publication Publication Date Title
AR245705A1 (en) Improvements in or relating to leukotriene antagonists
ES388869A1 (en) Cephalosporin intermediates and process therefor
GB1285016A (en) 3,4-dihydroisoquinoline derivatives
GB1041536A (en) Quaternary ammonium derivatives of dibenzo[a,d]-cycloheptadiene derivatives
GB1137764A (en) Improvements in or relating to pharmacologically-active secondary amines
ES391633A1 (en) 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides
GB1223889A (en) Process for the preparation of aziridine derivatives
ES351318A1 (en) Photoresist composition
ES405479A1 (en) Benzodiazepin-2-ones
KR840005426A (en) Process for preparing pyridylalkyl nitrate compound
GB1144039A (en) New naphthyl- and tetrahydronaphthyl-formamidines
GB1338764A (en) Optical elements
GB1169027A (en) Azetidine Derivatives
GB913578A (en) Preparation of tetracycline and tetracycline-urea compounds
GB758382A (en) Improvements in bis-(ú­-aminophenoxy) alkane derivatives
GB1348258A (en) 9-oxo-6.9-dihydro-4h-dioxino-4,5-g-quinolyl-8-carboxylic acids and their isomers, 10-oxo-7,10-dihydro-1h-dioxino-5,4-f-quinolyl- 9-carboxylic acids
ES379673A1 (en) A process for the manufacture of basic oxazine dyestuffs
ES351720A1 (en) Reaction of 2-aminobenzophenone amines and benzhydryl amines with di-leaveing group-substituted ethane
GB1417946A (en) Phthalazinone compounds
ES401342A1 (en) Pyridine derivatives
GB1216896A (en) New methinic dyestuffs derived from pyrylium and their method of preparation
GB1067151A (en) Benzthiazole derivatives
ES428457A1 (en) Preparation of salicylamide derivatives
ES356456A2 (en) Process for the Manufacture of Amine Derivatives
GB1199862A (en) A Process for the Manufacture of Dihydro-Benzdiaz[1,4]Epines