GB1217925A - Process for manufacture of phenyl-heterocyclic-acetic acid derivatives - Google Patents
Process for manufacture of phenyl-heterocyclic-acetic acid derivativesInfo
- Publication number
- GB1217925A GB1217925A GB2836168A GB2836168A GB1217925A GB 1217925 A GB1217925 A GB 1217925A GB 2836168 A GB2836168 A GB 2836168A GB 2836168 A GB2836168 A GB 2836168A GB 1217925 A GB1217925 A GB 1217925A
- Authority
- GB
- United Kingdom
- Prior art keywords
- het
- chain
- heterocyclic
- phenyl
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,217,925. Esters of alpha-(phenylheterocyclyl)alkanoic acids. IMPERIAL CHEMICAL INDUSTRIES Ltd. 6 May, 1969 [14 June, 1968], No. 28361/68. Heading C2C. Compounds of formula are prepared by reacting compounds of formula YXW(Het)CHR<SP>1</SP>R<SP>2</SP> with (R<SP>3</SP>) 2 CO 3 and M, MH, MNH 2 or C 1-3 - alkyl - OM, wherein "Het" is an oxazole or thiazole nucleus with the CR<SP>1</SP>R<SP>2</SP> side-chain in position 2, or a pyrimidine or pyridine nucleus with the CR<SP>1</SP>R<SP>2</SP> side-chain in position 2, 4 or 6; R<SP>2</SP> and W, H or Me, X is H or MeO, Y is Ph (possibly CF 3 or mono- or di-halogen i.e. F, Cl or Br, substituted), R<SP>1</SP> is Me or Et, R<SP>3</SP> is C 1-4 alkyl and M is Na or K, Y and the CR<SP>1</SP>R<SP>2</SP> side-chain being in non-adjacent positions in "Het". Pharmaceutically acceptable acid addition salts may be formed subsequently. Reference has been directed by the Comptroller to Specifications 1,099,389,1,121,922, 1,139,940 and 1,147,068.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2836168A GB1217925A (en) | 1968-06-14 | 1968-06-14 | Process for manufacture of phenyl-heterocyclic-acetic acid derivatives |
FR6919580A FR2070055B1 (en) | 1968-06-14 | 1969-06-12 | |
DE19691929963 DE1929963A1 (en) | 1968-06-14 | 1969-06-12 | Process for the preparation of esters |
CH908469A CH510664A (en) | 1968-06-14 | 1969-06-13 | Process for the preparation of esters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2836168A GB1217925A (en) | 1968-06-14 | 1968-06-14 | Process for manufacture of phenyl-heterocyclic-acetic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1217925A true GB1217925A (en) | 1971-01-06 |
Family
ID=10274447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2836168A Expired GB1217925A (en) | 1968-06-14 | 1968-06-14 | Process for manufacture of phenyl-heterocyclic-acetic acid derivatives |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH510664A (en) |
DE (1) | DE1929963A1 (en) |
FR (1) | FR2070055B1 (en) |
GB (1) | GB1217925A (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3401120A (en) * | 1965-10-23 | 1968-09-10 | Gaf Corp | Corrosion inhibitors |
GB1121922A (en) * | 1966-06-17 | 1968-07-31 | Ici Ltd | Pyrimidine derivatives |
GB1147068A (en) * | 1966-12-02 | 1969-04-02 | Ici Ltd | Phenyl-pyridine derivatives |
-
1968
- 1968-06-14 GB GB2836168A patent/GB1217925A/en not_active Expired
-
1969
- 1969-06-12 FR FR6919580A patent/FR2070055B1/fr not_active Expired
- 1969-06-12 DE DE19691929963 patent/DE1929963A1/en active Pending
- 1969-06-13 CH CH908469A patent/CH510664A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2070055A1 (en) | 1971-09-10 |
CH510664A (en) | 1971-07-31 |
FR2070055B1 (en) | 1974-11-15 |
DE1929963A1 (en) | 1970-01-15 |
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