GB1217925A - Process for manufacture of phenyl-heterocyclic-acetic acid derivatives - Google Patents

Process for manufacture of phenyl-heterocyclic-acetic acid derivatives

Info

Publication number
GB1217925A
GB1217925A GB2836168A GB2836168A GB1217925A GB 1217925 A GB1217925 A GB 1217925A GB 2836168 A GB2836168 A GB 2836168A GB 2836168 A GB2836168 A GB 2836168A GB 1217925 A GB1217925 A GB 1217925A
Authority
GB
United Kingdom
Prior art keywords
het
chain
heterocyclic
phenyl
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2836168A
Inventor
Philip Neil Edwards
Thomas Walton Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2836168A priority Critical patent/GB1217925A/en
Priority to FR6919580A priority patent/FR2070055B1/fr
Priority to DE19691929963 priority patent/DE1929963A1/en
Priority to CH908469A priority patent/CH510664A/en
Publication of GB1217925A publication Critical patent/GB1217925A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,217,925. Esters of alpha-(phenylheterocyclyl)alkanoic acids. IMPERIAL CHEMICAL INDUSTRIES Ltd. 6 May, 1969 [14 June, 1968], No. 28361/68. Heading C2C. Compounds of formula are prepared by reacting compounds of formula YXW(Het)CHR<SP>1</SP>R<SP>2</SP> with (R<SP>3</SP>) 2 CO 3 and M, MH, MNH 2 or C 1-3 - alkyl - OM, wherein "Het" is an oxazole or thiazole nucleus with the CR<SP>1</SP>R<SP>2</SP> side-chain in position 2, or a pyrimidine or pyridine nucleus with the CR<SP>1</SP>R<SP>2</SP> side-chain in position 2, 4 or 6; R<SP>2</SP> and W, H or Me, X is H or MeO, Y is Ph (possibly CF 3 or mono- or di-halogen i.e. F, Cl or Br, substituted), R<SP>1</SP> is Me or Et, R<SP>3</SP> is C 1-4 alkyl and M is Na or K, Y and the CR<SP>1</SP>R<SP>2</SP> side-chain being in non-adjacent positions in "Het". Pharmaceutically acceptable acid addition salts may be formed subsequently. Reference has been directed by the Comptroller to Specifications 1,099,389,1,121,922, 1,139,940 and 1,147,068.
GB2836168A 1968-06-14 1968-06-14 Process for manufacture of phenyl-heterocyclic-acetic acid derivatives Expired GB1217925A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB2836168A GB1217925A (en) 1968-06-14 1968-06-14 Process for manufacture of phenyl-heterocyclic-acetic acid derivatives
FR6919580A FR2070055B1 (en) 1968-06-14 1969-06-12
DE19691929963 DE1929963A1 (en) 1968-06-14 1969-06-12 Process for the preparation of esters
CH908469A CH510664A (en) 1968-06-14 1969-06-13 Process for the preparation of esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2836168A GB1217925A (en) 1968-06-14 1968-06-14 Process for manufacture of phenyl-heterocyclic-acetic acid derivatives

Publications (1)

Publication Number Publication Date
GB1217925A true GB1217925A (en) 1971-01-06

Family

ID=10274447

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2836168A Expired GB1217925A (en) 1968-06-14 1968-06-14 Process for manufacture of phenyl-heterocyclic-acetic acid derivatives

Country Status (4)

Country Link
CH (1) CH510664A (en)
DE (1) DE1929963A1 (en)
FR (1) FR2070055B1 (en)
GB (1) GB1217925A (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401120A (en) * 1965-10-23 1968-09-10 Gaf Corp Corrosion inhibitors
GB1121922A (en) * 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives
GB1147068A (en) * 1966-12-02 1969-04-02 Ici Ltd Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
FR2070055A1 (en) 1971-09-10
CH510664A (en) 1971-07-31
FR2070055B1 (en) 1974-11-15
DE1929963A1 (en) 1970-01-15

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