GB1206359A - Method for production of aminoalkyl fumarates - Google Patents

Method for production of aminoalkyl fumarates

Info

Publication number
GB1206359A
GB1206359A GB3697468A GB3697468A GB1206359A GB 1206359 A GB1206359 A GB 1206359A GB 3697468 A GB3697468 A GB 3697468A GB 3697468 A GB3697468 A GB 3697468A GB 1206359 A GB1206359 A GB 1206359A
Authority
GB
United Kingdom
Prior art keywords
fumarate
bis
fumarates
aminoalkyl
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3697468A
Inventor
Friziyan Nikolaevich Bodnarjuk
Mikahail Alexseevich Korshunov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NII MONOMEROV DLYA SINT KAUCHU
Original Assignee
NII MONOMEROV DLYA SINT KAUCHU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NII MONOMEROV DLYA SINT KAUCHU filed Critical NII MONOMEROV DLYA SINT KAUCHU
Priority to GB3697468A priority Critical patent/GB1206359A/en
Publication of GB1206359A publication Critical patent/GB1206359A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

1,206,359. Aminoalkyl fumarates. NAUCHNO - ISSLEDOVATELSKY INSTITUT MONOMEROV DLYA SINTETICHESKOGO KAUCHUKA " NIIMSK." 2 Aug., 1968, No. 36974/68. Heading C2C. Aminoalkyl fumarates of the general formula where B is a C 2-12 tertiary aliphatic amino group or a residue of piperidine or its homologue, A is H, CH 3 or -CH 2 B and n is 1 or 2, are obtained by reacting maleic anhydride with an alkanolamine of general formula at an elevated temperature in the presence of an esterification catalyst and in an inert organic solvent medium, and the water formed is continuously distilled off azeotropically. The esterification catalyst is preferably ferric sulphate, aluminium sulphate, mixtures thereof or mixtures of the sulphates with alkalis. The solvent may be benzene or its homologues, e.g. xylene and nitrogen is preferably bubbled through the reaction mixture. In the examples, the novel compounds bis-(2-diethylaminoisopropyl) - fumarate, bis - (2 - diallylaminoisopropyl) - fumarate, di - (2 - (N - piperidyl)- ethyl) - fumarate, bis - (1,3 - (dimethylamino)- isopropyl) - fumarate and bis - (1,3 - bis - (diethylamino)-isopropyl)-fumarate are prepared.
GB3697468A 1968-08-02 1968-08-02 Method for production of aminoalkyl fumarates Expired GB1206359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3697468A GB1206359A (en) 1968-08-02 1968-08-02 Method for production of aminoalkyl fumarates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3697468A GB1206359A (en) 1968-08-02 1968-08-02 Method for production of aminoalkyl fumarates

Publications (1)

Publication Number Publication Date
GB1206359A true GB1206359A (en) 1970-09-23

Family

ID=10392702

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3697468A Expired GB1206359A (en) 1968-08-02 1968-08-02 Method for production of aminoalkyl fumarates

Country Status (1)

Country Link
GB (1) GB1206359A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5520835A (en) * 1994-08-31 1996-05-28 The Procter & Gamble Company Automatic dishwashing compositions comprising multiquaternary bleach activators
US7638118B2 (en) 2003-09-02 2009-12-29 Givaudan Sa Aminoalkyl substituted esters and amides of fumaric acid for neutralizing malodor
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5520835A (en) * 1994-08-31 1996-05-28 The Procter & Gamble Company Automatic dishwashing compositions comprising multiquaternary bleach activators
US7638118B2 (en) 2003-09-02 2009-12-29 Givaudan Sa Aminoalkyl substituted esters and amides of fumaric acid for neutralizing malodor
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9090558B2 (en) 2013-03-14 2015-07-28 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10406133B2 (en) 2013-03-14 2019-09-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10596140B2 (en) 2013-03-14 2020-03-24 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11083703B2 (en) 2013-03-14 2021-08-10 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11230548B2 (en) 2013-03-14 2022-01-25 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11679092B2 (en) 2013-03-14 2023-06-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US11905298B2 (en) 2013-03-14 2024-02-20 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees