GB1205966A - 4'-DEMETHYL-EPIPODOPHYLLOTOXIN-beta-D-ETHYLIDENE-GLUCOSIDE - Google Patents
4'-DEMETHYL-EPIPODOPHYLLOTOXIN-beta-D-ETHYLIDENE-GLUCOSIDEInfo
- Publication number
- GB1205966A GB1205966A GB1946270A GB1946270A GB1205966A GB 1205966 A GB1205966 A GB 1205966A GB 1946270 A GB1946270 A GB 1946270A GB 1946270 A GB1946270 A GB 1946270A GB 1205966 A GB1205966 A GB 1205966A
- Authority
- GB
- United Kingdom
- Prior art keywords
- epipodophyllotoxin
- demethyl
- glucoside
- ethylidene
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Abstract
1,205,966. Epipodophyllotoxin derivative. SANDOZ Ltd. 27 Nov., 1967 [13 Dec., 1966], No. 19462/70. Divided out of 1,205,965. Heading C2C. Novel compound (I) in which R 1 is H and R 2 is CH 3 is prepared by reaction of (II) in which R 3 is H or carbobenzoxy and (III) R 1 -CO-R 2 or an acetal thereof with CH 3 OH, C 2 H 5 OH or HOCH 2 CH 2 OH in the presence of an acid catalyst and splitting off any carbobenzoxy radical in manner known per se. Pharmaceutical compositions for oral, parenteral or enteral application comprise a compound (I) and a suitable carrier or diluent and are used for therapy in the treatment of pathological processes accompanied by undesired cell multiplication, e.g. malignant neoplasms.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1775466A CH481913A (en) | 1966-12-13 | 1966-12-13 | Process for the production of new glucosides |
| CH1775666A CH481096A (en) | 1966-12-13 | 1966-12-13 | Process for the production of new glucosides |
| CH1775566A CH481095A (en) | 1966-12-13 | 1966-12-13 | Process for the preparation of new glucosides |
| CH1775366A CH481094A (en) | 1966-12-13 | 1966-12-13 | Process for the production of new glucosides |
| CH1775966A CH481097A (en) | 1966-12-13 | 1966-12-13 | Process for the preparation of a new glucoside |
| CH1775266A CH484101A (en) | 1966-12-13 | 1966-12-13 | Process for the production of new glucosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1205966A true GB1205966A (en) | 1970-09-23 |
Family
ID=27543911
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1946270A Expired GB1205966A (en) | 1966-12-13 | 1967-11-27 | 4'-DEMETHYL-EPIPODOPHYLLOTOXIN-beta-D-ETHYLIDENE-GLUCOSIDE |
| GB5384467A Expired GB1205965A (en) | 1966-12-13 | 1967-11-27 | Epipodophyllotoxin glucoside derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5384467A Expired GB1205965A (en) | 1966-12-13 | 1967-11-27 | Epipodophyllotoxin glucoside derivatives |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT285062B (en) |
| BE (1) | BE707822A (en) |
| CA (1) | CA952103A (en) |
| CH (7) | CH481094A (en) |
| CS (1) | CS152448B2 (en) |
| DE (1) | DE1643521C3 (en) |
| DK (1) | DK131429B (en) |
| FI (1) | FI48585C (en) |
| FR (2) | FR1572185A (en) |
| GB (2) | GB1205966A (en) |
| NL (1) | NL6716635A (en) |
| SE (1) | SE348192B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| US4935504A (en) * | 1987-12-18 | 1990-06-19 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-acyl derivatives |
| US5326753A (en) * | 1990-01-19 | 1994-07-05 | Nippon Kayaku Kabushiki Kaisha | Freeze-dried composition containing a 2-dimethylamino etoposide derivative |
| US5463040A (en) * | 1994-06-28 | 1995-10-31 | Teva Pharmaceutical Industries, Ltd. | Method of preparing etoposide |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904768A (en) * | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
-
1966
- 1966-12-13 CH CH1775366A patent/CH481094A/en not_active IP Right Cessation
- 1966-12-13 CH CH1775466A patent/CH481913A/en not_active IP Right Cessation
- 1966-12-13 CH CH1775966A patent/CH481097A/en not_active IP Right Cessation
- 1966-12-13 CH CH1445369A patent/CH544752A/en not_active IP Right Cessation
- 1966-12-13 CH CH1775566A patent/CH481095A/en not_active IP Right Cessation
- 1966-12-13 CH CH1775266A patent/CH484101A/en not_active IP Right Cessation
- 1966-12-13 CH CH1775666A patent/CH481096A/en not_active IP Right Cessation
-
1967
- 1967-11-27 GB GB1946270A patent/GB1205966A/en not_active Expired
- 1967-11-27 GB GB5384467A patent/GB1205965A/en not_active Expired
- 1967-12-07 NL NL6716635A patent/NL6716635A/xx unknown
- 1967-12-09 DE DE1967S0113215 patent/DE1643521C3/en not_active Expired
- 1967-12-11 BE BE707822D patent/BE707822A/xx not_active IP Right Cessation
- 1967-12-11 CA CA007,216A patent/CA952103A/en not_active Expired
- 1967-12-11 FR FR1572185D patent/FR1572185A/fr not_active Expired
- 1967-12-11 CS CS877367A patent/CS152448B2/cs unknown
- 1967-12-12 AT AT1119667A patent/AT285062B/en not_active IP Right Cessation
- 1967-12-12 FI FI331067A patent/FI48585C/en active
- 1967-12-12 DK DK620967A patent/DK131429B/en not_active IP Right Cessation
- 1967-12-12 SE SE1706767A patent/SE348192B/xx unknown
-
1968
- 1968-03-08 FR FR142954A patent/FR8031M/fr not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| US4935504A (en) * | 1987-12-18 | 1990-06-19 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-acyl derivatives |
| US5326753A (en) * | 1990-01-19 | 1994-07-05 | Nippon Kayaku Kabushiki Kaisha | Freeze-dried composition containing a 2-dimethylamino etoposide derivative |
| US5463040A (en) * | 1994-06-28 | 1995-10-31 | Teva Pharmaceutical Industries, Ltd. | Method of preparing etoposide |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
| US6420377B1 (en) | 1997-03-12 | 2002-07-16 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CH481094A (en) | 1969-11-15 |
| CH544752A (en) | 1974-01-15 |
| FI48585C (en) | 1974-11-11 |
| CA952103A (en) | 1974-07-30 |
| FR1572185A (en) | 1969-06-27 |
| DK131429C (en) | 1975-12-15 |
| CH481096A (en) | 1969-11-15 |
| CH481095A (en) | 1969-11-15 |
| CH481913A (en) | 1969-11-30 |
| DE1643521C3 (en) | 1978-09-21 |
| DK131429B (en) | 1975-07-14 |
| DE1643521B2 (en) | 1978-01-19 |
| SE348192B (en) | 1972-08-28 |
| GB1205965A (en) | 1970-09-23 |
| CH484101A (en) | 1970-01-15 |
| CS152448B2 (en) | 1973-12-19 |
| DE1643521A1 (en) | 1971-04-08 |
| BE707822A (en) | 1968-06-11 |
| AT285062B (en) | 1970-10-12 |
| FR8031M (en) | 1970-08-03 |
| NL6716635A (en) | 1968-06-14 |
| FI48585B (en) | 1974-07-31 |
| CH481097A (en) | 1969-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |