GB1180616A - Improvements in or relating to Hexahydroazepine Compounds and the Manufacture thereof - Google Patents

Improvements in or relating to Hexahydroazepine Compounds and the Manufacture thereof

Info

Publication number
GB1180616A
GB1180616A GB4488369A GB4488369A GB1180616A GB 1180616 A GB1180616 A GB 1180616A GB 4488369 A GB4488369 A GB 4488369A GB 4488369 A GB4488369 A GB 4488369A GB 1180616 A GB1180616 A GB 1180616A
Authority
GB
United Kingdom
Prior art keywords
azepin
benzoyl
benzoylhexahydro
phenylhydrazones
hexahydroazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4488369A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1180616A publication Critical patent/GB1180616A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

1,180,616. Phenylhydrazones of 1-benzoylhexahydro-4H-azepin-4-one. UPJOHN CO. 17 April, 1967 [10 May, 1966], No. 44883/69. Divided out of 1,180,615. Heading C2C. Novel phenylhydrazones of 1-benzoylhexahydro-4H-azepin-4-one of the formula wherein R and R<SP>1</SP> which may be the same or different are H, C 1-3 alkoxy, C 1-3 alkyl, F, Cl or Br, with the proviso that at least one of the two or the positions (to the hydrazino group) in R and R<SP>1</SP> substituted benzene ring is unsubstituted and # is phenyl are prepared by heating the appropriate phenylhydrazine with 1 - benzoyl - hexahydro - 4H - azepin - 4 - one, which is obtained either by the microbiological oxidation with Sporotrichum sulphurescens ATCC 7159 of 1-benzoylhexamethyleneimine, obtained by reacting benzoyl chloride with hexamethyleneimine, or the oxidation of 1- benzoyl - 4 - hydroxyhexahydro - 4H - azepine, which is produced in the above microbiological oxidation reaction.
GB4488369A 1966-05-10 1967-04-17 Improvements in or relating to Hexahydroazepine Compounds and the Manufacture thereof Expired GB1180616A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54888066A 1966-05-10 1966-05-10

Publications (1)

Publication Number Publication Date
GB1180616A true GB1180616A (en) 1970-02-04

Family

ID=24190763

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4488369A Expired GB1180616A (en) 1966-05-10 1967-04-17 Improvements in or relating to Hexahydroazepine Compounds and the Manufacture thereof
GB1757867A Expired GB1180615A (en) 1966-05-10 1967-04-17 Novel Substituted Hexahydroazepino-(4,5-b) Indoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1757867A Expired GB1180615A (en) 1966-05-10 1967-04-17 Novel Substituted Hexahydroazepino-(4,5-b) Indoles

Country Status (9)

Country Link
BE (1) BE698268A (en)
CH (1) CH506543A (en)
DE (1) DE1695943A1 (en)
ES (1) ES340258A1 (en)
FR (1) FR6699M (en)
GB (2) GB1180616A (en)
GR (1) GR35044B (en)
IL (2) IL36801A (en)
NL (1) NL6706513A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485634B2 (en) 2002-05-24 2009-02-03 Exelixis, Inc. Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934342A1 (en) * 1978-08-24 1980-03-13 Martin E Kuehne METHOD FOR PRODUCING + VINCADIFFORMIN AND RELATED DERIVATIVES AND INTERMEDIATE COMPOUNDS
FR2663935A1 (en) * 1990-06-27 1992-01-03 Adir NOVEL 1,2,3,4,5,6-HEXAHYDROAZEPINO [4,5-B] INDOLES AND 1,2,3,4-TETRAHYDROBETHACARBOLINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7030109B2 (en) 1999-07-19 2006-04-18 Pharmacia & Upjohn Company 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
MY122278A (en) * 1999-07-19 2006-04-29 Upjohn Co 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
AU2001269781A1 (en) * 2000-07-06 2002-01-21 Pharmacia And Upjohn Company Substituted 2,3,7,8,9,10,11,12-octahydroazepino(4,5-b)pyrano(3,2-e) indoles
WO2002024700A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
JP4679517B2 (en) * 2003-07-23 2011-04-27 エグゼリクシス， インコーポレイテッド Azepine derivatives as drugs
WO2023092045A1 (en) 2021-11-17 2023-05-25 Terran Biosciences, Inc. Salt and solid forms of tabernanthalog

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485634B2 (en) 2002-05-24 2009-02-03 Exelixis, Inc. Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents

Also Published As

Publication number Publication date
FR6699M (en) 1969-02-10
IL36801A (en) 1971-11-29
GB1180615A (en) 1970-02-04
DE1695943A1 (en) 1971-05-13
ES340258A1 (en) 1968-06-01
IL27776A (en) 1971-11-29
CH506543A (en) 1971-04-30
GR35044B (en) 1968-07-31
NL6706513A (en) 1967-11-13
BE698268A (en) 1967-11-10

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