GB1174854A - New Biologically Active Conjugates - Google Patents

New Biologically Active Conjugates

Info

Publication number
GB1174854A
GB1174854A GB31374/67A GB3137467A GB1174854A GB 1174854 A GB1174854 A GB 1174854A GB 31374/67 A GB31374/67 A GB 31374/67A GB 3137467 A GB3137467 A GB 3137467A GB 1174854 A GB1174854 A GB 1174854A
Authority
GB
United Kingdom
Prior art keywords
extract
acid
biologically active
pollen extract
naja
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31374/67A
Inventor
Patrick James Mill
Michael Alan Cresswell
Joseph George Feinberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Priority to GB31374/67A priority Critical patent/GB1174854A/en
Priority to IL30258A priority patent/IL30258A/en
Priority to CH998868A priority patent/CH526590A/en
Priority to FR1584763D priority patent/FR1584763A/fr
Priority to SE6809321A priority patent/SE383100B/en
Priority to BE717689D priority patent/BE717689A/xx
Priority to LU56423D priority patent/LU56423A1/xx
Priority to NL6809538.A priority patent/NL160723C/en
Priority to DE1768841A priority patent/DE1768841C3/en
Priority to ES355853A priority patent/ES355853A1/en
Priority to FR168874A priority patent/FR7784M/fr
Publication of GB1174854A publication Critical patent/GB1174854A/en
Priority to US05/278,880 priority patent/US4003792A/en
Priority to SE7511288A priority patent/SE400652B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,174,854. Antigenic and therapeutic materials. MILES LABORATORIES Inc. 23 Aug., 1968 [7 July, 1967], No. 31374/67. Heading A5B. [Also in Division C3] An therapeutic preparation for injection comprises a sterile solution of the sodium salt of a conjugate of a polysaccharide containing acid groups and which forms a water-soluble sodium salt and a water-insoluble calcium salt and a biologically active substance containing basic amino or phenolic hydroxy groups to which it is linked via amide and/or ester linkages such that the final product still contains free acid groups and forms salts as defined above. Specified polysaccharides are pectin, pectic acid, alginic acid, celluronic acid, carageenan and lickerin uronic acid. Biologically active substances used in the examples are insulin, ovalbumin, timothy pollen extract, trypsin, cocksfoot pollen extract, ragweed pollen extract, diphtheria toxin, birch pollen extract, horse dander extract, cat epithalial extract, lactalbumin, haddock extract, dry rot extract, Baker's yeast extract, Naja-Naja venom, bee venom, tetanus toxoid, ficin and chymotrypsin. Reaction may be effected in aqueous solution using a coupling agent to form the amide and/or ester linkages.
GB31374/67A 1967-07-01 1967-07-07 New Biologically Active Conjugates Expired GB1174854A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB31374/67A GB1174854A (en) 1967-07-07 1967-07-07 New Biologically Active Conjugates
IL30258A IL30258A (en) 1967-07-07 1968-06-26 New conjugates of acid polysaccharides and complex organic substances
CH998868A CH526590A (en) 1967-07-07 1968-07-04 Conjugates of biologicals with acidic polysaccharides
NL6809538.A NL160723C (en) 1967-07-07 1968-07-05 PROCESS FOR PREPARING AN IMMUNOLOGICALLY ACTIVE ORGANIC COMPOUND.
SE6809321A SE383100B (en) 1967-07-07 1968-07-05 PROCEDURE FOR THE PREPARATION OF IMMUNOLOGICALLY ACTIVE CONJUGATES OF ALLERGENS OR TOXIC SUBSTANCES
BE717689D BE717689A (en) 1967-07-07 1968-07-05
LU56423D LU56423A1 (en) 1967-07-07 1968-07-05
FR1584763D FR1584763A (en) 1967-07-07 1968-07-05
DE1768841A DE1768841C3 (en) 1967-07-07 1968-07-05 Covalently bound conjugates of acidic polysaccharides and complex organic substances
ES355853A ES355853A1 (en) 1967-07-07 1968-07-06 New Biologically Active Conjugates
FR168874A FR7784M (en) 1967-07-07 1968-10-04
US05/278,880 US4003792A (en) 1967-07-01 1972-08-08 Conjugates of acid polysaccharides and complex organic substances
SE7511288A SE400652B (en) 1967-07-07 1975-10-08 METHOD OF MAKING CONJUGATE OF INSULIN WITH ACIDIC POLYSACCARIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31374/67A GB1174854A (en) 1967-07-07 1967-07-07 New Biologically Active Conjugates

Publications (1)

Publication Number Publication Date
GB1174854A true GB1174854A (en) 1969-12-17

Family

ID=10322153

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31374/67A Expired GB1174854A (en) 1967-07-01 1967-07-07 New Biologically Active Conjugates

Country Status (10)

Country Link
BE (1) BE717689A (en)
CH (1) CH526590A (en)
DE (1) DE1768841C3 (en)
ES (1) ES355853A1 (en)
FR (2) FR1584763A (en)
GB (1) GB1174854A (en)
IL (1) IL30258A (en)
LU (1) LU56423A1 (en)
NL (1) NL160723C (en)
SE (2) SE383100B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003792A (en) 1967-07-01 1977-01-18 Miles Laboratories, Inc. Conjugates of acid polysaccharides and complex organic substances
DE3032488A1 (en) * 1979-09-05 1981-04-02 Kabushiki Kaisha Hayashibara, Seibutsu-Kagaku Kenkyujo, Okayama METHOD FOR PRODUCING A VACCINE
US4663287A (en) * 1983-06-15 1987-05-05 Gist-Brocades N.V. Biologically active conjugates and their preparation and use
GB2270920A (en) * 1992-09-25 1994-03-30 Univ Keele Alginate-bioactive agent conjugates
US5384256A (en) * 1992-04-25 1995-01-24 Nestec S.A. Pectin-modified lipase from Mucor javanicus with lowered saturated/unsaturated fatty acid ratio
US5393538A (en) * 1992-04-25 1995-02-28 Nestec S.A. Preparation of crumb-flavored milk chocolate

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1243832A (en) * 1968-10-25 1971-08-25 Beecham Group Ltd Vaccines
US3957580A (en) * 1974-03-27 1976-05-18 Pfizer Inc. Immobilized microbial cells
JPS57136528A (en) * 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
DE3443877A1 (en) * 1984-06-09 1985-12-12 Hoechst Ag Insulin preparations, process for their preparation, and their use
IT1203814B (en) * 1986-06-30 1989-02-23 Fidia Farmaceutici ESTERS OF ALGINIC ACID
FR2817870B1 (en) * 2000-12-08 2006-07-28 Skw Nature Products Holding Fr CONJUGATED POLYMERS BASED ON PECTINES AND THEIR APPLICATION AS EMULSIFIERS

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003792A (en) 1967-07-01 1977-01-18 Miles Laboratories, Inc. Conjugates of acid polysaccharides and complex organic substances
DE3032488A1 (en) * 1979-09-05 1981-04-02 Kabushiki Kaisha Hayashibara, Seibutsu-Kagaku Kenkyujo, Okayama METHOD FOR PRODUCING A VACCINE
US4663287A (en) * 1983-06-15 1987-05-05 Gist-Brocades N.V. Biologically active conjugates and their preparation and use
US5384256A (en) * 1992-04-25 1995-01-24 Nestec S.A. Pectin-modified lipase from Mucor javanicus with lowered saturated/unsaturated fatty acid ratio
US5393538A (en) * 1992-04-25 1995-02-28 Nestec S.A. Preparation of crumb-flavored milk chocolate
GB2270920A (en) * 1992-09-25 1994-03-30 Univ Keele Alginate-bioactive agent conjugates
GB2270920B (en) * 1992-09-25 1997-04-02 Univ Keele Alginate-bioactive agent conjugates
US5622718A (en) * 1992-09-25 1997-04-22 Keele University Alginate-bioactive agent conjugates

Also Published As

Publication number Publication date
SE7511288L (en) 1975-10-08
FR7784M (en) 1970-03-23
NL160723C (en) 1979-12-17
FR1584763A (en) 1970-01-02
DE1768841B2 (en) 1980-01-31
SE400652B (en) 1978-04-03
NL160723B (en) 1979-07-16
SE383100B (en) 1976-03-01
ES355853A1 (en) 1970-03-01
DE1768841C3 (en) 1980-09-25
LU56423A1 (en) 1968-10-21
IL30258A (en) 1972-02-29
DE1768841A1 (en) 1971-11-18
CH526590A (en) 1972-08-15
NL6809538A (en) 1969-01-09
BE717689A (en) 1968-12-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years