GB1174493A - New Benzimidazoles and process for their preparation - Google Patents

New Benzimidazoles and process for their preparation

Info

Publication number
GB1174493A
GB1174493A GB3293367A GB3293367A GB1174493A GB 1174493 A GB1174493 A GB 1174493A GB 3293367 A GB3293367 A GB 3293367A GB 3293367 A GB3293367 A GB 3293367A GB 1174493 A GB1174493 A GB 1174493A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
benzimidazoles
halogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3293367A
Inventor
Phillippe Rohrbach
Jean Blum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MANUFACTURES J R BOTTU
Original Assignee
MANUFACTURES J R BOTTU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MANUFACTURES J R BOTTU filed Critical MANUFACTURES J R BOTTU
Priority to GB3293367A priority Critical patent/GB1174493A/en
Priority to BE714652D priority patent/BE714652A/xx
Priority to CH668268A priority patent/CH497433A/en
Priority to FR1561049D priority patent/FR1561049A/fr
Priority to DE19681770362 priority patent/DE1770362A1/en
Priority to NL6806574A priority patent/NL6806574A/xx
Priority to FR151710A priority patent/FR7408M/fr
Publication of GB1174493A publication Critical patent/GB1174493A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Abstract

1,174,493. Benzimidazoles. MFRS. J. R. BOTTU. 9 May, 1968 [10 May, 1967; 18 July, 1967], Nos. 21804/67 and 32933/67. Heading C2C. Novel compounds of the formula (wherein R is H, halogen, CF 3 , C 1-4 alkyl or C 1-4 alkoxy; and R<SP>1</SP> and R<SP>2</SP> are each halogen, CF 3 , C 1-4 alkyl, C 1-4 alkoxy, OH, C 1-4 aminoalkoxy, mono- or di-alkyl-amino-alkoxy with 1-4 C atoms in each alkyl residue, or CO 2 H) and acid-addition salts thereof are prepared by oxidizing compounds of the formula (e.g. by heating with nitrobenzene or m-dinitrobenzene) which are in turn prepared by condensing the appropriately substituted N- phenyl - o - phenylenediamine with the appropriately substituted benzaldehyde. The benzimidazoles of the invention are antiinflammatory and analgesic agents, and they may be made up into pharmaceutical compositions with suitable carriers.
GB3293367A 1967-05-10 1967-05-10 New Benzimidazoles and process for their preparation Expired GB1174493A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB3293367A GB1174493A (en) 1967-05-10 1967-05-10 New Benzimidazoles and process for their preparation
BE714652D BE714652A (en) 1967-05-10 1968-05-03
CH668268A CH497433A (en) 1967-05-10 1968-05-06 (A) Benzimidazole derivs. of general formula (I): R = H, halogen, trifluoromethyl, alkyl (C1-C4) or alkoxy (C1-C4); R1 and R2 are same or different haloge
FR1561049D FR1561049A (en) 1967-05-10 1968-05-07
DE19681770362 DE1770362A1 (en) 1967-05-10 1968-05-09 Benzimidazoles and processes for their preparation
NL6806574A NL6806574A (en) 1967-05-10 1968-05-09
FR151710A FR7408M (en) 1967-05-10 1968-05-14

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3293367A GB1174493A (en) 1967-05-10 1967-05-10 New Benzimidazoles and process for their preparation
GB2180467 1967-05-10

Publications (1)

Publication Number Publication Date
GB1174493A true GB1174493A (en) 1969-12-17

Family

ID=26255530

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3293367A Expired GB1174493A (en) 1967-05-10 1967-05-10 New Benzimidazoles and process for their preparation

Country Status (6)

Country Link
BE (1) BE714652A (en)
CH (1) CH497433A (en)
DE (1) DE1770362A1 (en)
FR (2) FR1561049A (en)
GB (1) GB1174493A (en)
NL (1) NL6806574A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007263A1 (en) * 1993-09-09 1995-03-16 Schering Aktiengesellschaft 1,2-di(hetero)arylbenzimidazole derivatives, their preparation and their use as prostacyclin (pgi2) mimetics
WO1995030659A1 (en) * 1994-05-10 1995-11-16 Warner-Lambert Company Benzimidazole and imidazopyridine derivatives, their preparation and their use as dopaminergic agents, esp. selective for the dopamine d3 receptor
EP0694535A1 (en) * 1994-04-29 1996-01-31 Eli Lilly And Company Non-peptidyl tachykinin receptor antagonists
WO2004000817A2 (en) * 2002-06-24 2003-12-31 Pfizer Products Inc. Benzimidazole compounds and their use as estrogen agonists/antagonists
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
US7329679B2 (en) 2000-01-27 2008-02-12 Schering Aktiengesellschaft 1,2 Diarylbenzimidazoles and their pharmaceutical use
JP2008303211A (en) * 2003-03-13 2008-12-18 Idemitsu Kosan Co Ltd New nitrogen-containing heterocyclic derivative and organic electroluminescent device by using the same

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007263A1 (en) * 1993-09-09 1995-03-16 Schering Aktiengesellschaft 1,2-di(hetero)arylbenzimidazole derivatives, their preparation and their use as prostacyclin (pgi2) mimetics
EP0694535A1 (en) * 1994-04-29 1996-01-31 Eli Lilly And Company Non-peptidyl tachykinin receptor antagonists
WO1995030659A1 (en) * 1994-05-10 1995-11-16 Warner-Lambert Company Benzimidazole and imidazopyridine derivatives, their preparation and their use as dopaminergic agents, esp. selective for the dopamine d3 receptor
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
US7329679B2 (en) 2000-01-27 2008-02-12 Schering Aktiengesellschaft 1,2 Diarylbenzimidazoles and their pharmaceutical use
US7345075B2 (en) 2000-01-27 2008-03-18 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
WO2004000817A2 (en) * 2002-06-24 2003-12-31 Pfizer Products Inc. Benzimidazole compounds and their use as estrogen agonists/antagonists
WO2004000817A3 (en) * 2002-06-24 2004-05-21 Pfizer Prod Inc Benzimidazole compounds and their use as estrogen agonists/antagonists
JP2008303211A (en) * 2003-03-13 2008-12-18 Idemitsu Kosan Co Ltd New nitrogen-containing heterocyclic derivative and organic electroluminescent device by using the same

Also Published As

Publication number Publication date
NL6806574A (en) 1968-11-11
DE1770362A1 (en) 1971-10-21
FR1561049A (en) 1969-03-21
FR7408M (en) 1969-11-03
BE714652A (en) 1968-09-30
CH497433A (en) 1970-10-15

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee