GB1166364A - N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same - Google Patents

N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same

Info

Publication number
GB1166364A
GB1166364A GB4684367A GB4684367A GB1166364A GB 1166364 A GB1166364 A GB 1166364A GB 4684367 A GB4684367 A GB 4684367A GB 4684367 A GB4684367 A GB 4684367A GB 1166364 A GB1166364 A GB 1166364A
Authority
GB
United Kingdom
Prior art keywords
formula
reacting
compound
aminoalkyl
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4684367A
Inventor
William Blythe Wright Jr
Herbert Joseph Brabander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB1166364A publication Critical patent/GB1166364A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

1,166,364. N-(tert-aminoalkyl) amide derivatives. AMERICAN CYANAMID CO. 13 Oct., 1967 [25 Nov., 1966 (2)], No. 46843/67. Heading C2C. Novel N-(tert.-aminoalkyl) amide derivatives of the general Formula III wherein R 2 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl; n is 2, 3 or 4; A is a thiophone radical of the formula or a phenyl radical of the formula R and R 1 are hydrogen, C 1-6 alkyl, or halogen; and B is 1-aryl.4-p-perazinyl, 4-arylpiperidino, or 4 - aryl - 3,6 - dihydro - 1(2H) - pyridyl, with the proviso when B is 1 .aryl.4.piperazinyl, A may not be phenyl or substituted phenyl and the pharmaceutically acceptable acid addition salts thereof are prepared by any of the following methods: (1) Reacting a compound A-Y with an amine of the formula B-C n H 2n -(H)R 2 , where Y is a reactive moiety being an acid halide, an ester, an ahydride or an amide. (2) Reacting a compound of formula with a compound H-B, wherein X is halogen, C 1-6 alkylsulphonyloxy, or monocyclic arylsulphonyloxy. Compounds of the above general Formula III in which A is a thiophene radical may also be prepared by the following methods: (3) Reading a compound of the formula ACON(R 2 )H with a compound of the formula X-C n H 2n B ; (4) Reacting an acid of the formula ACOOH with N,N<SP>1</SP>-carbonyldhmidazole and treating the thus obtained ketone with an amine of the formula B-C n H 2n N(R 2 )H ; (5) Reacting an acid of the formula ACOOH with an amine of the formula in the presence of a carbodiimide. N - (2 - Bromoethyl) - and N - (3 - bromopropyl) - 2 - thiopheneearboxamides are obtained by reacting 2-phenoyl chloride with 2-bromoethylamine and 3-bromopropylamine respectively. N - (2 - Bromoethyl) - and N - (2 - chloroethyl) N - methyl - benzamides are prepared by reacting benzoyl chloride with 2-bromoethylamine and 2-chloroethylmethylamine respectively. Pharmaceutical compositions, suitable for oral administration and having analgesic, antiinflammatory, diuretic and anti-depressant properties, contain the above novel compounds or their non-toxic pharmaceutically acceptable acid addition salts as the active ingredient and a pharmaceutically acceptable carrier or diluent.
GB4684367A 1966-11-25 1967-10-13 N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same Expired GB1166364A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59681066A 1966-11-25 1966-11-25
US59683166A 1966-11-25 1966-11-25

Publications (1)

Publication Number Publication Date
GB1166364A true GB1166364A (en) 1969-10-08

Family

ID=27082649

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4684367A Expired GB1166364A (en) 1966-11-25 1967-10-13 N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same

Country Status (9)

Country Link
BE (1) BE707032A (en)
CH (1) CH509311A (en)
DE (1) DE1670007A1 (en)
DK (1) DK127979B (en)
ES (1) ES347622A1 (en)
FR (1) FR7590M (en)
GB (1) GB1166364A (en)
IL (1) IL28799A (en)
NL (1) NL6715434A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048045A1 (en) * 1980-09-12 1982-03-24 Duphar International Research B.V Phenyl piperazine derivatives having antiagressive activity
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
WO1996040136A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1009846B (en) * 1954-03-27 1957-06-06 Strautmann & Soehne O H G B Musmuehle
DE3163803D1 (en) * 1980-02-14 1984-07-05 Grigg Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
GB8823042D0 (en) * 1988-09-30 1988-11-09 Lilly Sa Organic compounds & their use as pharmaceuticals
GB8823040D0 (en) * 1988-09-30 1988-11-09 Lilly Sa Organic compounds & their use as pharmaceuticals

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048045A1 (en) * 1980-09-12 1982-03-24 Duphar International Research B.V Phenyl piperazine derivatives having antiagressive activity
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
WO1996040136A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5977115A (en) * 1995-06-07 1999-11-02 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6274583B1 (en) 1995-06-07 2001-08-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists

Also Published As

Publication number Publication date
IL28799A (en) 1972-07-26
NL6715434A (en) 1968-05-27
FR7590M (en) 1970-01-12
ES347622A1 (en) 1969-06-01
DE1670007A1 (en) 1971-01-21
DK127979B (en) 1974-02-11
CH509311A (en) 1971-06-30
BE707032A (en) 1968-05-24

Similar Documents

Publication Publication Date Title
GB1173942A (en) New 2,3-Dihydro-1,4-Benzoxazines
IE811830L (en) Indoles.
HUT43570A (en) Process for preparing novel decahydroquinoline derivatives and their salts, as well as pharmaceutics comprising the derivatives
GB1166364A (en) N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same
GB1254332A (en) Amino acids and their derivatives and processes for preparing them
GB1318291A (en) Carboxamide derivatives and fungicidal compositions containing them
GB1252479A (en)
GB1436307A (en) Diaromatic o-aminoalkyl-oximes
GB1383888A (en) Amino ether derivatives of orthothymatic esters
GB1509547A (en) Tetracycline derivatives and process for preparing them
GB1174349A (en) Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof
GB1305458A (en)
GB1047245A (en)
GB1417355A (en) Substituted piperazine and homopiperazine derivatives
GB1458898A (en) Ortho alkoxyanilides a process for their preparation and pharmaceutical compositions containing them
GB1436502A (en) Amide derivatives of 3-benzoylphenyl-alkanoic acids
GB1305725A (en)
GB1192248A (en) A process for the preparation of Novel Diphenylamine Derivatives
GB1469410A (en) Benzodioxole derivatives
GB1488411A (en) 3,4-dihydro-4-arylquinolin-4-ol derivatives
GB1269404A (en) 0-substituted-2,5-diphenylpyrroles
GB1126672A (en) Sulphamylanthranilic acid amides and process for their manufacture
GB1446833A (en) Hydroxamic acid derivatives of substituted a-aminooxycarboxylic acids and a process for the preparation thereof
GB1172788A (en) N-(Azabicycloalkylisopropyl)-Aminopyridine Derivatives
ES445477A1 (en) (indolin-1-yl)-guanidines

Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees