GB1161638A - Anti-Inflammatory Compositions - Google Patents
Anti-Inflammatory CompositionsInfo
- Publication number
- GB1161638A GB1161638A GB45317/67A GB4531767A GB1161638A GB 1161638 A GB1161638 A GB 1161638A GB 45317/67 A GB45317/67 A GB 45317/67A GB 4531767 A GB4531767 A GB 4531767A GB 1161638 A GB1161638 A GB 1161638A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- phenyl
- amino
- alkoxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- -1 and "Ar" is iphenyl Chemical group 0.000 abstract 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 235000010290 biphenyl Nutrition 0.000 abstract 2
- 239000004305 biphenyl Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 101100188555 Arabidopsis thaliana OCT6 gene Proteins 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- YDVJBLJCSLVMSY-UHFFFAOYSA-N carbamoyl cyanide Chemical compound NC(=O)C#N YDVJBLJCSLVMSY-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,161,638. Anti-inflammatory compositions. ENDO LABORATORIES Inc. 4 Oct., 1967 [6 Oct., 1966], No. 45317/67. Heading ASB. [Also in Division C2] . Anti-inflammatory compositions comprise a carrier and a compound of the formula wherein R 1 is H, lower alkyl, lower alkenyl, cycloalkyl having up to 6 C atoms, or benzyl, phenyl or benzoyl optionally substituted with lower alkyl or alkoxy groups; R 2 , R 3 and R 4 are H, lower alkyl, lower alkenyl, cycloalkyl having up to 6 C atoms, phenyl, phenyl-lower alkyl; halo-, lower alkoxy- or lower alkylsubstituted phenyl, and "Ar" is iphenyl, naphthyl, biphenyl or mono-, di- or tri-substituted phenyl, naphthyl or biphenyl in which the substituents are chosen from; hydroxy, lower alkoxy, lower alkyl, lower alkylene dioxy, phenoxy, nitro, halo, amino, lower alkanoyl amino, benzylidene amino, lower alkyl amino, di-Lower alkyl amino, di-lower alkyl amino-N- oxide, ureido, mercapto, lower alkyl thio, phenyl thio, halo-lower alkyl, lower alkanoyl, lower alkyl suphonyl, lower alkyl smilphinyl, sulphamyl, cyano, carboxamide, carbo-lower alkoxy and carboxhydrazide; the term "lower" signifying from, 1 to 4 C atoms. They may be in conventional forms for oral, parenteral and rectal administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58476266A | 1966-10-06 | 1966-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1161638A true GB1161638A (en) | 1969-08-13 |
Family
ID=24338685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB45317/67A Expired GB1161638A (en) | 1966-10-06 | 1967-10-04 | Anti-Inflammatory Compositions |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE1617455A1 (en) |
| FR (1) | FR7319M (en) |
| GB (1) | GB1161638A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002392A2 (en) * | 1977-12-06 | 1979-06-13 | Teijin Limited | 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them |
| EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
-
1967
- 1967-10-04 GB GB45317/67A patent/GB1161638A/en not_active Expired
- 1967-10-06 DE DE19671617455 patent/DE1617455A1/en active Pending
- 1967-10-06 FR FR123516A patent/FR7319M/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002392A2 (en) * | 1977-12-06 | 1979-06-13 | Teijin Limited | 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them |
| EP0002392A3 (en) * | 1977-12-06 | 1979-07-11 | Teijin Limited | 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them |
| EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1617455A1 (en) | 1971-04-08 |
| FR7319M (en) | 1969-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |