GB1159480A - 4H-Benzo[4,5]Cyclohepta[1,2-b]-Thiophene Derivatives - Google Patents
4H-Benzo[4,5]Cyclohepta[1,2-b]-Thiophene DerivativesInfo
- Publication number
- GB1159480A GB1159480A GB47266/66A GB4726666A GB1159480A GB 1159480 A GB1159480 A GB 1159480A GB 47266/66 A GB47266/66 A GB 47266/66A GB 4726666 A GB4726666 A GB 4726666A GB 1159480 A GB1159480 A GB 1159480A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- methyl
- acid
- compound
- signifies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,159,480. Benzocycloheptathiophen derivatives. SANDOZ Ltd. 21 Oct., 1966 [3 Nov., 1965], No. 47266/66. Addition to 1,089,483. Heading C2C. Novel compounds of Formula (I) in which either Z signifies the radical -CH 2 CH 2 - and each X signifies a hydrogen atom or together they signify a second bond, or Z signifies the radical -CH=CH- and both X together signify a second bond, and their acid addition salts, are prepared by reacting a compound corresponding to Formula (I) above in which the hydrogen atom on the nitrogen atom of the piperidine ring is replaced by a methyl group with a chloroformic acid ester of formula Cl-COOR in which R represents an alkyl group having 1-4 carbon atoms, or an aralkyl group having 7-10 carbon atoms, and subjecting the resulting compound in which the methyl group is replaced by a -COOR radical to hydrolysis and, when an acid addition salt is required, reacting the resulting compound of Formula (I) with an acid. 4 - (1 - Methyl 4 piperidyl) - 9,10 - dihydro- 4H - benzo - [4,5] - cyclokepta - [1,2 - b] - thiophen may be prepared by heating a solution of 4-(1- methyl - 4 - piperidylidene) - or 4 - hydroxy- 4 - (1 - methyl - 4 - piperidyl) - 9,10 - dihydro- 4H - benzo - [4,5] - cyclohepta - [1,2 - b] - thiophen in glacial acetic acid at reflux temperature for 1¢ hours with red phosphorus and hydriodic acid. Therapeutic compositions having anti-serotonin and anti-cholinergic activity which may be administered enterally or parenterally contain as active ingredient a compound of Formula (I) above or an acid addition salt thereof, while such compositions containing a compound I in which Z is -CH 2 CH 2 - and the two symbols X signify a second bond also possess histaminolytic activity.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH127564A CH440321A (en) | 1964-02-04 | 1964-02-04 | Process for the preparation of new heterocyclic compounds |
CH1324664 | 1964-10-13 | ||
CH806165A CH473138A (en) | 1964-02-04 | 1965-06-09 | Process for the preparation of new 9,10-dihydro-4H-benzo (4,5) cyclohepta (1,2-b) thiophene derivatives |
CH1519165A CH473146A (en) | 1964-02-04 | 1965-11-03 | Process for the preparation of new 4H-Benzo (4,5) cyclohepta (1,2-b) thiophene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1159480A true GB1159480A (en) | 1969-07-23 |
Family
ID=27428140
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3355/65A Expired GB1089483A (en) | 1964-02-04 | 1965-01-26 | Improvements in or relating to 4h-benzo(4,5)cyclohepta (1,2-b) thiophene derivatives |
GB47266/66A Expired GB1159480A (en) | 1964-02-04 | 1966-10-21 | 4H-Benzo[4,5]Cyclohepta[1,2-b]-Thiophene Derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3355/65A Expired GB1089483A (en) | 1964-02-04 | 1965-01-26 | Improvements in or relating to 4h-benzo(4,5)cyclohepta (1,2-b) thiophene derivatives |
Country Status (12)
Country | Link |
---|---|
BE (2) | BE659178A (en) |
BR (2) | BR6566936D0 (en) |
CH (2) | CH473138A (en) |
DE (2) | DE1238040B (en) |
ES (1) | ES332985A2 (en) |
FI (1) | FI42216B (en) |
FR (4) | FR1441486A (en) |
GB (2) | GB1089483A (en) |
IL (1) | IL22905A (en) |
NL (2) | NL125442C (en) |
OA (1) | OA01524A (en) |
SE (1) | SE306323B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU195800B (en) * | 1983-10-13 | 1988-07-28 | Sandoz Ltd | Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them |
PT1218007E (en) | 1999-09-13 | 2011-10-27 | Bridge Pharma Inc | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
-
1965
- 1965-01-26 GB GB3355/65A patent/GB1089483A/en not_active Expired
- 1965-01-28 OA OA51413A patent/OA01524A/en unknown
- 1965-01-29 NL NL6501154A patent/NL125442C/xx active
- 1965-02-01 DE DES95277A patent/DE1238040B/en active Pending
- 1965-02-02 BE BE659178A patent/BE659178A/xx unknown
- 1965-02-02 FR FR4164A patent/FR1441486A/en not_active Expired
- 1965-02-02 FI FI0244/65A patent/FI42216B/fi active
- 1965-02-03 IL IL22905A patent/IL22905A/en unknown
- 1965-02-03 SE SE1405/65A patent/SE306323B/xx unknown
- 1965-02-04 BR BR166936/65A patent/BR6566936D0/en unknown
- 1965-04-30 FR FR15304A patent/FR4369M/fr not_active Expired
- 1965-06-09 CH CH806165A patent/CH473138A/en unknown
- 1965-08-09 NL NL6510326A patent/NL6510326A/xx unknown
- 1965-08-09 BE BE668052A patent/BE668052A/xx unknown
- 1965-08-10 FR FR27925A patent/FR91208E/en not_active Expired
- 1965-11-03 CH CH1519165A patent/CH473146A/en unknown
-
1966
- 1966-10-21 GB GB47266/66A patent/GB1159480A/en not_active Expired
- 1966-10-28 DE DE19661620420 patent/DE1620420A1/en active Pending
- 1966-10-31 BR BR184229/66A patent/BR6684229D0/en unknown
- 1966-11-02 FR FR82202A patent/FR92121E/en not_active Expired
- 1966-11-02 ES ES332985A patent/ES332985A2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL6510326A (en) | 1966-12-12 |
DE1238040B (en) | 1967-04-06 |
CH473146A (en) | 1969-05-31 |
ES332985A2 (en) | 1968-03-16 |
BE659178A (en) | 1965-08-02 |
NL6501154A (en) | 1965-08-05 |
SE306323B (en) | 1968-11-25 |
OA01524A (en) | 1969-07-21 |
CH473138A (en) | 1969-05-31 |
GB1089483A (en) | 1967-11-01 |
FR1441486A (en) | 1966-06-10 |
BE668052A (en) | 1966-02-09 |
NL125442C (en) | 1968-06-17 |
FR92121E (en) | 1968-09-27 |
DE1620420A1 (en) | 1970-03-12 |
BR6566936D0 (en) | 1973-08-14 |
BR6684229D0 (en) | 1973-12-26 |
FR4369M (en) | 1966-08-22 |
FI42216B (en) | 1970-03-02 |
FR91208E (en) | 1968-05-03 |
IL22905A (en) | 1969-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
416 | Proceeding under section 16 patents act 1949 | ||
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |