GB1142448A - The manufacture of phenazine derivatives - Google Patents

The manufacture of phenazine derivatives

Info

Publication number
GB1142448A
GB1142448A GB5320167A GB5320167A GB1142448A GB 1142448 A GB1142448 A GB 1142448A GB 5320167 A GB5320167 A GB 5320167A GB 5320167 A GB5320167 A GB 5320167A GB 1142448 A GB1142448 A GB 1142448A
Authority
GB
United Kingdom
Prior art keywords
phenazine
treating
monoxide
dioxide
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5320167A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1142448A publication Critical patent/GB1142448A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Vehicle Body Suspensions (AREA)

Abstract

1,142,448. Phenazine N-oxides. F. HOFFMANN-LA ROCHE & CO. A.G. 22 Nov., 1967 [25 Nov., 1966], No. 53201/67. Heading C2C. Novel phenazine derivatives of the general formula where R<SP>1</SP> represents lower alkyl or benzyl are prepared by (a) treating a phenazine N- monoxide of the formula where R<SP>1</SP> is as defined above and R<SP>2</SP> represents a lower alkyl or benzyl group with a halide of a Group III element and treating the resulting N-monoxide of the general formula with a hydroperoxide or (b) treating a 1,6- dialkoxy (or dibenzyloxy) phenazine N,N-dioxide with a halide of a Group III element and separating the product from the mixture obtained or (c) treating 1,6-phenazene diol-5,10- dioxide with an alkylating agent or a benzylating agent and separating the product from the mixture obtained. The N-monoxide and N,N-dwxide starting materials are obtained by treating the corresponding 1,6-dialkoxy (or dibenzyloxy) phenazine with a hydroperoxide and isolating the product from the mixture obtained. Pharmaceutical compositions comprising compounds of Formula I or an N,N-dioxide in which neither R<SP>1</SP> nor R<SP>2</SP> is hydrogen, together with a pharmaceutically acceptable carrier, are administered orally or parenterally or have germicidal and broad-spectrum anti-biotic activity.
GB5320167A 1966-11-25 1967-11-22 The manufacture of phenazine derivatives Expired GB1142448A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59679466A 1966-11-25 1966-11-25

Publications (1)

Publication Number Publication Date
GB1142448A true GB1142448A (en) 1969-02-05

Family

ID=24388733

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5320167A Expired GB1142448A (en) 1966-11-25 1967-11-22 The manufacture of phenazine derivatives

Country Status (14)

Country Link
AT (2) AT281852B (en)
BE (1) BE706861A (en)
CA (1) CA946397A (en)
CH (3) CH520694A (en)
DE (2) DE1795724C3 (en)
ES (1) ES347576A1 (en)
FR (1) FR1545331A (en)
GB (1) GB1142448A (en)
GR (1) GR38359B (en)
IL (1) IL28972A (en)
NL (2) NL6715787A (en)
NO (1) NO123528B (en)
PH (2) PH11778A (en)
SE (3) SE366988B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104974100A (en) * 2015-07-07 2015-10-14 江苏省农业科学院 Phenazine compounds originated from lysobacter antibioticus OH13 and preparation method and application thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH532589A (en) * 1969-05-14 1973-01-15 Hoffmann La Roche Process for the preparation of phenazine derivatives
US3681331A (en) * 1970-04-02 1972-08-01 Hoffmann La Roche 1-hydroxy-6-amino alkoxy-phenazine 5,10-dioxides
CH575213A5 (en) * 1972-09-05 1976-05-14 Ciba Geigy Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104974100A (en) * 2015-07-07 2015-10-14 江苏省农业科学院 Phenazine compounds originated from lysobacter antibioticus OH13 and preparation method and application thereof

Also Published As

Publication number Publication date
DE1695212A1 (en) 1971-03-18
CH521358A (en) 1972-04-15
NL6715787A (en) 1968-05-27
DE1795724A1 (en) 1974-02-28
SE366988B (en) 1974-05-13
FR1545331A (en) 1968-11-08
DE1695212C3 (en) 1974-09-19
IL28972A (en) 1973-03-30
CH512500A (en) 1971-09-15
AT281852B (en) 1970-06-10
DE1795724B2 (en) 1978-09-28
GR38359B (en) 1969-10-30
SE366985B (en) 1974-05-13
CA946397A (en) 1974-04-30
DE1695212B2 (en) 1974-02-14
SE349036B (en) 1972-09-18
NO123528B (en) 1971-12-06
BE706861A (en) 1968-05-22
PH11778A (en) 1978-07-05
PH12441A (en) 1979-03-01
NL7409550A (en) 1974-09-25
AT281851B (en) 1970-06-10
CH520694A (en) 1972-03-31
ES347576A1 (en) 1969-02-01
DE1795724C3 (en) 1979-05-23

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