GB1118187A - Derivatives of dialkylcysteines and allied compounds - Google Patents

Derivatives of dialkylcysteines and allied compounds

Info

Publication number
GB1118187A
GB1118187A GB23659/64A GB2365964A GB1118187A GB 1118187 A GB1118187 A GB 1118187A GB 23659/64 A GB23659/64 A GB 23659/64A GB 2365964 A GB2365964 A GB 2365964A GB 1118187 A GB1118187 A GB 1118187A
Authority
GB
United Kingdom
Prior art keywords
present
formula
cooh
absent
dialkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23659/64A
Inventor
Nicholas Ercoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Priority to GB23659/64A priority Critical patent/GB1118187A/en
Priority to US461855A priority patent/US3466312A/en
Priority to DEE29470A priority patent/DE1301003B/en
Priority to BR170245/65A priority patent/BR6570245D0/en
Priority to DE19651793545 priority patent/DE1793545A1/en
Priority to CH794665A priority patent/CH478149A/en
Priority to FR19915A priority patent/FR5051M/fr
Priority to OA52073A priority patent/OA01742A/en
Publication of GB1118187A publication Critical patent/GB1118187A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/285—Arsenic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/29—Antimony or bismuth compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/90—Antimony compounds
    • C07F9/902—Compounds without antimony-carbon linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/94—Bismuth compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds of formula <FORM:1118187/C2/1> and acid addition salts thereof, wherein M is Sb, As, Bi, Fe, Se or Te, X may be present or absent and if present represents a group of formula CH(COOH)(NH2).C(CH3)2.S-or CH(COOH)(NH2).C(CH3)(C2H5).S-Y is dimethylcysteine or methylethylcysteine, Z is X, -SbX2, or a carbon linked substituted or unsubstituted alkyl, aryl or aralkyl group, or the remainder of an organic residue comprising a heterocyclic ring in which M is included, k is 0, 1, or 2, n is an integer consistent with the valencies of M and Z and each Z may represent the same or different radicals if n > 1 and m is an integer such that the total number of dialkyl cysteinyl groups and complex forming dialkyl cysteine molecules present does not exceed the maximum number of co-ordinate bonds which can be formed by the metal or if X is present m may be 0, are prepared by reacting the selected dialkylcysteine with a compound of formula Zn.M.Au, where A is an inorganic radical or radicals having a total valency u and Z may be absent, i.e. n may be 0, optionally in a polar solvent or alkaline solution.
GB23659/64A 1964-06-08 1964-06-08 Derivatives of dialkylcysteines and allied compounds Expired GB1118187A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GB23659/64A GB1118187A (en) 1964-06-08 1964-06-08 Derivatives of dialkylcysteines and allied compounds
US461855A US3466312A (en) 1964-06-08 1965-06-07 Derivatives of dialkyl-cysteines and allied compounds
DEE29470A DE1301003B (en) 1964-06-08 1965-06-08 Use of dialkyl cysteines to reduce the toxicity of pharmacologically active metal compounds
BR170245/65A BR6570245D0 (en) 1964-06-08 1965-06-08 PROCESS OF PREPARATION OF DIALKYLCYSTEINE DERIVATIVES
DE19651793545 DE1793545A1 (en) 1964-06-08 1965-06-08 Dialkylcysteine derivatives and processes for their preparation
CH794665A CH478149A (en) 1964-06-08 1965-06-08 Process for the preparation of novel dialkylcysteine derivatives
FR19915A FR5051M (en) 1964-06-08 1965-06-08
OA52073A OA01742A (en) 1964-06-08 1965-06-10 Metal and organometallic derivatives of dialkylcysteines and their manufacturing process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB23659/64A GB1118187A (en) 1964-06-08 1964-06-08 Derivatives of dialkylcysteines and allied compounds
GB3631964 1964-09-04

Publications (1)

Publication Number Publication Date
GB1118187A true GB1118187A (en) 1968-06-26

Family

ID=26256656

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23659/64A Expired GB1118187A (en) 1964-06-08 1964-06-08 Derivatives of dialkylcysteines and allied compounds

Country Status (7)

Country Link
US (1) US3466312A (en)
BR (1) BR6570245D0 (en)
CH (1) CH478149A (en)
DE (2) DE1793545A1 (en)
FR (1) FR5051M (en)
GB (1) GB1118187A (en)
OA (1) OA01742A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786573A (en) * 1971-07-20 1973-01-22 Hoechst Ag MEDICINAL PRODUCT BASED ON ORGANIC ARSENICAL COMPOUNDS AND BENZIMIDAZOLE DERIVATIVES
US4167564A (en) * 1974-09-23 1979-09-11 Albion Laboratories, Inc. Biological assimilation of metals
US4487780A (en) * 1979-09-18 1984-12-11 Scheinberg Israel H Method of treatment of rheumatoid arthritis
DE3725214A1 (en) * 1986-09-27 1988-03-31 Licentia Gmbh IMPATT DIODE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1672615A (en) * 1927-06-29 1928-06-05 Kharasch Morris Selig Alkyl mercuric sulphur compound and process of producing it
US1684920A (en) * 1928-01-24 1928-09-18 Lilly Co Eli Water-soluble organic compound of antimony and process of producing it
US2559061A (en) * 1946-07-15 1951-07-03 Parke Davis & Co Phenylcyanamides and methods for obtaining the same
US2701812A (en) * 1951-06-26 1955-02-08 Dainippon Pharmaceutical Co Diarylarsenious acid derivatives and the preparation thereof
NL123752C (en) * 1958-12-22
US3281461A (en) * 1963-11-07 1966-10-25 Squibb & Sons Inc Process for preparing penicillamine
US3297531A (en) * 1963-12-11 1967-01-10 Ernst A H Friedheim Complexes of trivalent antimony with penicillamine, and admixtures of excess penicillamine with said complexes

Also Published As

Publication number Publication date
US3466312A (en) 1969-09-09
DE1793545A1 (en) 1972-03-09
BR6570245D0 (en) 1973-08-28
OA01742A (en) 1969-12-15
DE1301003B (en) 1969-08-14
CH478149A (en) 1969-09-15
FR5051M (en) 1967-05-08

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