GB1101366A - Pharmaceutical compositions and a process for the manufacture thereof - Google Patents
Pharmaceutical compositions and a process for the manufacture thereofInfo
- Publication number
- GB1101366A GB1101366A GB37310/66A GB3731066A GB1101366A GB 1101366 A GB1101366 A GB 1101366A GB 37310/66 A GB37310/66 A GB 37310/66A GB 3731066 A GB3731066 A GB 3731066A GB 1101366 A GB1101366 A GB 1101366A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzodiazepin
- exchange resin
- groups
- acidic ion
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
Abstract
A pharmaceutical composition comprises 7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one adsorbed on an acidic ion-exchange resin, e.g. a copolymer of styrene and 8% by wt. of divinyl benzene which is either sulphonated or carboxylated, or a polysaccharide (dextran) cross-linked wither with sulphoethyl groups orcarboxymethyl groups. The composition may be made by treating a solution of the above benzodiazepin-2-one compound in methylene chloride with the acidic ion-exchange resin and subsequently distilling off the solvent. The composition may also contain water, carboxymethyl cellulose, sodium benzoate, sodium saccharin, sodium citrate, sugar, and citric acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1177965 | 1965-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1101366A true GB1101366A (en) | 1968-01-31 |
Family
ID=4376790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB37310/66A Expired GB1101366A (en) | 1965-08-20 | 1966-08-19 | Pharmaceutical compositions and a process for the manufacture thereof |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPS507079B1 (en) |
BE (1) | BE685589A (en) |
DE (1) | DE1617513C3 (en) |
DK (1) | DK111277B (en) |
ES (1) | ES330391A1 (en) |
FI (1) | FI45726C (en) |
FR (1) | FR6063M (en) |
GB (1) | GB1101366A (en) |
IL (1) | IL26306A (en) |
IT (1) | IT1053660B (en) |
MY (1) | MY6900059A (en) |
NL (1) | NL6610569A (en) |
NO (1) | NO120752B (en) |
SE (1) | SE351978B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1175915A1 (en) * | 2000-07-27 | 2002-01-30 | Rohm And Haas Company | A method for preparing resinates |
EP1175914A2 (en) * | 2000-07-27 | 2002-01-30 | Rohm And Haas Company | A resinate composition |
EP1293209A1 (en) * | 2001-09-17 | 2003-03-19 | Rohm And Haas Company | Oral pharmaceutical dosage forms with reduced potential for drug abuse |
EP1467769B1 (en) * | 2002-01-18 | 2008-05-28 | Rohm and Haas Company | Use of a resinate in the preparation of a formulation for smoking cessation |
-
1966
- 1966-06-24 DE DE1617513A patent/DE1617513C3/en not_active Expired
- 1966-07-27 NL NL6610569A patent/NL6610569A/xx unknown
- 1966-07-27 FI FI661994A patent/FI45726C/en active
- 1966-08-09 JP JP41051951A patent/JPS507079B1/ja active Pending
- 1966-08-10 IL IL26306A patent/IL26306A/en unknown
- 1966-08-17 BE BE685589D patent/BE685589A/xx not_active IP Right Cessation
- 1966-08-17 FR FR73217A patent/FR6063M/fr not_active Expired
- 1966-08-19 ES ES0330391A patent/ES330391A1/en not_active Expired
- 1966-08-19 NO NO164367A patent/NO120752B/no unknown
- 1966-08-19 GB GB37310/66A patent/GB1101366A/en not_active Expired
- 1966-08-19 DK DK425066AA patent/DK111277B/en unknown
- 1966-08-19 SE SE11240/66A patent/SE351978B/xx unknown
- 1966-08-20 IT IT19168/66A patent/IT1053660B/en active
-
1969
- 1969-12-31 MY MY196959A patent/MY6900059A/en unknown
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1175915A1 (en) * | 2000-07-27 | 2002-01-30 | Rohm And Haas Company | A method for preparing resinates |
EP1175914A2 (en) * | 2000-07-27 | 2002-01-30 | Rohm And Haas Company | A resinate composition |
EP1175914A3 (en) * | 2000-07-27 | 2002-05-02 | Rohm And Haas Company | A resinate composition |
KR100869486B1 (en) * | 2000-07-27 | 2008-11-19 | 롬 앤드 하스 캄파니 | A method for preparing resinates |
EP1293209A1 (en) * | 2001-09-17 | 2003-03-19 | Rohm And Haas Company | Oral pharmaceutical dosage forms with reduced potential for drug abuse |
EP1467769B1 (en) * | 2002-01-18 | 2008-05-28 | Rohm and Haas Company | Use of a resinate in the preparation of a formulation for smoking cessation |
CN1615156B (en) * | 2002-01-18 | 2012-05-30 | 罗门哈斯公司 | Preparation of resinates |
Also Published As
Publication number | Publication date |
---|---|
DE1617513B2 (en) | 1973-08-16 |
BE685589A (en) | 1967-02-17 |
NL6610569A (en) | 1967-02-21 |
FI45726C (en) | 1972-09-11 |
NO120752B (en) | 1970-11-30 |
JPS507079B1 (en) | 1975-03-20 |
FI45726B (en) | 1972-05-31 |
MY6900059A (en) | 1969-12-31 |
IL26306A (en) | 1970-02-19 |
FR6063M (en) | 1968-05-27 |
SE351978B (en) | 1972-12-18 |
ES330391A1 (en) | 1967-10-16 |
DE1617513A1 (en) | 1970-12-23 |
DE1617513C3 (en) | 1974-04-18 |
IT1053660B (en) | 1981-10-10 |
DK111277B (en) | 1968-07-15 |
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