GB1096344A - Improvements in or relating to organic compounds - Google Patents
Improvements in or relating to organic compoundsInfo
- Publication number
- GB1096344A GB1096344A GB12233/65A GB1223365A GB1096344A GB 1096344 A GB1096344 A GB 1096344A GB 12233/65 A GB12233/65 A GB 12233/65A GB 1223365 A GB1223365 A GB 1223365A GB 1096344 A GB1096344 A GB 1096344A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- signifies
- water
- cyclohepta
- benzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
9,10 - Dihydro - 4H - benzo - [4,5] - cyclohepta-[1,2-b]-thiophene derivatives of the formula <FORM:1096344/C2/1> in which R1 signifies an alkyl radical, containing from 1 to 4 carbon atoms inclusive, each of R2 and R3 signifies a hydrogen atom or one of them signifies a hydrogen atom and the other an atom of chlorine or bromine, and their acid addition salts, are produced by a process in which water is split off from a compound of the formula <FORM:1096344/C2/2> and, when an acid addition salt is required, the product is reacted with an organic or inorganic acid. The starting material is obtained by reduction of a compound of the formula <FORM:1096344/C2/3> which may be obtained by reacting a 9,10-dihydro - 4H - benzo - [4,5] - cyclohepta - [1,2-b]-thiophen-4-one of the formula <FORM:1096344/C2/4> with a pyrrolidone-(2) derivative of the formula <FORM:1096344/C2/5> in the presence of an alkali metal amide or hydride. The products having the first formula may be used as pharmaceuticals either on their own or in the form of appropriate medicinal preparations for administration either orally, enterally or parenterally; suitable adjuvants are for tablets and dragees: lactose, starch, talc and stearic acid, and for injectable solutions: water, alcohols, glycerine and vegetable oils. These pharmaceuticals have an antidepressive effect and are preferably used in the form of their physiologically acceptable, water-soluble salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH426464A CH441375A (en) | 1964-04-02 | 1964-04-02 | Process for the preparation of new thiophene derivatives |
CH87565 | 1965-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1096344A true GB1096344A (en) | 1967-12-29 |
Family
ID=25685972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB12233/65A Expired GB1096344A (en) | 1964-04-02 | 1965-03-23 | Improvements in or relating to organic compounds |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE661887A (en) |
FR (1) | FR4584M (en) |
GB (1) | GB1096344A (en) |
IL (1) | IL23275A (en) |
NL (1) | NL6503931A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2036568A1 (en) * | 2007-09-12 | 2009-03-18 | Nestec S.A. | Wolfberries and inflammation |
WO2010049707A2 (en) * | 2008-10-31 | 2010-05-06 | Provexis Natural Products Limited | Fruit extracts |
KR20110131452A (en) * | 2010-05-31 | 2011-12-07 | 강원대학교산학협력단 | Composition for prevention and treatment of anti-inflammatory effects comprising purple pigments isolated from purple-potato |
US20120321732A1 (en) * | 2006-06-02 | 2012-12-20 | Provexis Natural Products Limited | Therapeutic uses of tomato extracts |
-
1965
- 1965-03-23 GB GB12233/65A patent/GB1096344A/en not_active Expired
- 1965-03-26 NL NL6503931A patent/NL6503931A/xx unknown
- 1965-03-31 BE BE661887A patent/BE661887A/xx unknown
- 1965-04-01 IL IL2327565A patent/IL23275A/en unknown
- 1965-06-28 FR FR22607A patent/FR4584M/fr not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120321732A1 (en) * | 2006-06-02 | 2012-12-20 | Provexis Natural Products Limited | Therapeutic uses of tomato extracts |
EP2036568A1 (en) * | 2007-09-12 | 2009-03-18 | Nestec S.A. | Wolfberries and inflammation |
WO2010049707A2 (en) * | 2008-10-31 | 2010-05-06 | Provexis Natural Products Limited | Fruit extracts |
KR20110131452A (en) * | 2010-05-31 | 2011-12-07 | 강원대학교산학협력단 | Composition for prevention and treatment of anti-inflammatory effects comprising purple pigments isolated from purple-potato |
Non-Patent Citations (5)
Title |
---|
ABBEY ET AL: "effect os quecetin supplementation on repeated.sprint performance xanthine oxidase activity and inflammation", INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, vol. 21, no. 2, 2011, pages 91 - 96 * |
BURTON-FREEMAN ET AL: "protective activity of processed tomato products on postprandial oxidation and inflammation a clinical trial in healty weight men and women", MOLECULAR NUTRITION AND FOOD RESEARCH, vol. 56, no. 4, 2012, pages 622 - 631 * |
KONRAD ET AL: "the acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners", INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, vol. 21, no. 4, 2011, pages 338 - 346 * |
NIEMAN ET AL: "effects of quercetin and EGCG on mitochondrial biogenesis and immunity", MEDICINE AND SCIENCE IN SPORT AND EXERCISE, vol. 41, no. 7, 2009, pages 1467 - 1475 * |
SPILLER ET AL: "anti-inflammatory effects of red pepper(capsicum baccatum) on carrageenan-and antigen-incluced inflammation", JOURNAL OF PHARMACY AND PHARMACOLOY , vol. 60, no. 4, 2008, pages 473 - 478 * |
Also Published As
Publication number | Publication date |
---|---|
BE661887A (en) | 1965-09-30 |
FR4584M (en) | 1966-11-14 |
NL6503931A (en) | 1965-10-04 |
IL23275A (en) | 1968-10-24 |
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