GB1086326A - Anilides and hydrazides - Google Patents
Anilides and hydrazidesInfo
- Publication number
- GB1086326A GB1086326A GB3280763A GB3280763A GB1086326A GB 1086326 A GB1086326 A GB 1086326A GB 3280763 A GB3280763 A GB 3280763A GB 3280763 A GB3280763 A GB 3280763A GB 1086326 A GB1086326 A GB 1086326A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- aniline
- substituted
- phenyl
- nhr5
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the Formula (I) <FORM:1086326/C2/1> (in which R2 and R3 are both 1-8C-alkyl groups or R2 and R3 together with the adjacent C atoms form a cyclobutane, cyclopentane, cyclohexane or tetrahydropyran ring; R is a group -NR4.NHR5, in which R4 is H or a phenyl or an alkoxy or aralkoxy substituted phenyl group, and R5 is a phenyl or an alkoxy- or aralkoxy-substituted phenyl group, or an anilino or substituted anilino group; and R1 is a group COR or a carboxy or an esterified carboxy group, or where R2 and R3 are other than 1-8C-alkyl, H) are prepared by reacting a diacid halide of the formula <FORM:1086326/C2/2> where X is a halogen atom, with a hydrazine HNR4.NHR5 or aniline or an appropriately substituted aniline in the presence of an acid binding agent, or by converting an appropriate diacid to its diester, hydrolysing this to its half-ester converting this to the half-ester halide and then reacting it with an appropriate aniline or hydrazine. Pharmaceutical compositions having anti-inflammatory activity comprise compounds (I) and a carrier therefor. The compositions may be in a form suitable for parenteral or topical administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3280763A GB1086326A (en) | 1963-08-20 | 1963-08-20 | Anilides and hydrazides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3280763A GB1086326A (en) | 1963-08-20 | 1963-08-20 | Anilides and hydrazides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1086326A true GB1086326A (en) | 1967-10-11 |
Family
ID=10344282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3280763A Expired GB1086326A (en) | 1963-08-20 | 1963-08-20 | Anilides and hydrazides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1086326A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987005898A2 (en) * | 1986-03-31 | 1987-10-08 | Rhone-Poulenc Nederlands B.V. | Use of malonic acid derivative compounds for retarding plant growth |
| US5123951A (en) * | 1986-03-31 | 1992-06-23 | Rhone-Poulenc Nederland B.V. | Synergistic plant growth regulator compositions |
| CN110818586A (en) * | 2019-10-09 | 2020-02-21 | 中国药科大学 | Cyclopentanedioamide ligand, synthesis method, application in coupling reaction for synthesizing arylamine derivative and catalytic system |
-
1963
- 1963-08-20 GB GB3280763A patent/GB1086326A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987005898A2 (en) * | 1986-03-31 | 1987-10-08 | Rhone-Poulenc Nederlands B.V. | Use of malonic acid derivative compounds for retarding plant growth |
| WO1987005898A3 (en) * | 1986-03-31 | 1988-05-05 | Rhone Poulenc Bv | Use of malonic acid derivative compounds for retarding plant growth |
| JPS63503065A (en) * | 1986-03-31 | 1988-11-10 | ローヌープーラン・ネーデルランド・ベー・ベー | Use of malonic acid derivative compounds to inhibit plant growth |
| US5123951A (en) * | 1986-03-31 | 1992-06-23 | Rhone-Poulenc Nederland B.V. | Synergistic plant growth regulator compositions |
| AU639777B2 (en) * | 1986-03-31 | 1993-08-05 | Rhone-Poulenc Nederlands B.V. | Malonic acid derivative compounds |
| JP2693774B2 (en) | 1986-03-31 | 1997-12-24 | ローヌープーラン・ネーデルランド・ベー・ベー | Use of malonic acid derivative compounds for controlling plant growth |
| CN110818586A (en) * | 2019-10-09 | 2020-02-21 | 中国药科大学 | Cyclopentanedioamide ligand, synthesis method, application in coupling reaction for synthesizing arylamine derivative and catalytic system |
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