GB1085076A - Process for the preparation of lactams - Google Patents

Process for the preparation of lactams

Info

Publication number
GB1085076A
GB1085076A GB3070464A GB3070464A GB1085076A GB 1085076 A GB1085076 A GB 1085076A GB 3070464 A GB3070464 A GB 3070464A GB 3070464 A GB3070464 A GB 3070464A GB 1085076 A GB1085076 A GB 1085076A
Authority
GB
United Kingdom
Prior art keywords
formula
hydrogen
schiff
reaction
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3070464A
Inventor
Richard Emery Brown
Robert Israel Meltzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Pharmaceutical Co filed Critical Warner Lambert Pharmaceutical Co
Priority to GB3070464A priority Critical patent/GB1085076A/en
Publication of GB1085076A publication Critical patent/GB1085076A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises a process for the production of compounds of the general formula <FORM:1085076/C2/1> wherein R1 or R2 is hydrogen or lower alkoxy, R3 is hydrogen or lower alkyl and R4 is keto hydroxy or hydrogen and n is 1 or 2 where "lower" indicator radicals containing 1 to 6 carbon atoms by reaction of a substituted carbodiimide of the formula R1-N = C = N-R1 in which R1 is isopropyl, cyclohexyl or isobutyl, e.g. N,N1-dicyclohexylcarbodiimide, with a Schiff's base of formula <FORM:1085076/C2/2> to effect ring closure. The Schiff's base of the formula may be prepared by the reaction of a compound of formula <FORM:1085076/C2/3> wherein R1 and R2 have the above meanings, with a compound of formula <FORM:1085076/C2/4> wherein R3 and R4 have the above meanings.
GB3070464A 1964-08-04 1964-08-04 Process for the preparation of lactams Expired GB1085076A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3070464A GB1085076A (en) 1964-08-04 1964-08-04 Process for the preparation of lactams

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3070464A GB1085076A (en) 1964-08-04 1964-08-04 Process for the preparation of lactams

Publications (1)

Publication Number Publication Date
GB1085076A true GB1085076A (en) 1967-09-27

Family

ID=10311833

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3070464A Expired GB1085076A (en) 1964-08-04 1964-08-04 Process for the preparation of lactams

Country Status (1)

Country Link
GB (1) GB1085076A (en)

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