GB1067827A - Improvements in or relating to ergostine, ergostinine and derivatives thereof - Google Patents

Improvements in or relating to ergostine, ergostinine and derivatives thereof

Info

Publication number
GB1067827A
GB1067827A GB41448/63A GB4144863A GB1067827A GB 1067827 A GB1067827 A GB 1067827A GB 41448/63 A GB41448/63 A GB 41448/63A GB 4144863 A GB4144863 A GB 4144863A GB 1067827 A GB1067827 A GB 1067827A
Authority
GB
United Kingdom
Prior art keywords
acid
ergostinine
ergostine
relating
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41448/63A
Inventor
Albert Hofmann
Albert Frey
Hans Ott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1067827A publication Critical patent/GB1067827A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Novel compounds of the formula <FORM:1067827/C2/1> in which <FORM:1067827/C2/2> signifies the radical -CH=C< or -CH2-CH< and their acid addition salts are obtained in a process which comprises reacting (A) lysergic acid chloride hydrochloride or 9: 10-dihydrolysergic acid chloride hydrochloride with (B) a salt of 2-amino-2-ethyl-5-benzyl - 10b - hydroxy - 3,6 - dioxo - octahydrooxazolo - [3: 2-a] pyrrolo [2: 1-c] pyrazine in the presence of an acid acceptor and, when an acid addition salt is required, salifying with an organic or inorganic acid. Pharmaceutical compositions having spasmolytic activity comprise the above compounds and a pharmaceutical carrier.
GB41448/63A 1962-11-08 1963-10-21 Improvements in or relating to ergostine, ergostinine and derivatives thereof Expired GB1067827A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1306962 1962-11-08

Publications (1)

Publication Number Publication Date
GB1067827A true GB1067827A (en) 1967-05-03

Family

ID=4389007

Family Applications (2)

Application Number Title Priority Date Filing Date
GB41448/63A Expired GB1067827A (en) 1962-11-08 1963-10-21 Improvements in or relating to ergostine, ergostinine and derivatives thereof
GB47328/66A Expired GB1067828A (en) 1962-11-08 1963-10-21 The production of ergot alkaloids and intermediates therefor

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB47328/66A Expired GB1067828A (en) 1962-11-08 1963-10-21 The production of ergot alkaloids and intermediates therefor

Country Status (11)

Country Link
BR (1) BR6354399D0 (en)
CY (1) CY549A (en)
DK (1) DK116220B (en)
ES (1) ES293286A2 (en)
FR (1) FR3208M (en)
GB (2) GB1067827A (en)
LU (1) LU44759A1 (en)
MY (1) MY7000175A (en)
NO (1) NO119141B (en)
OA (1) OA00701A (en)
SE (1) SE313312B (en)

Also Published As

Publication number Publication date
NO119141B (en) 1970-03-31
SE313312B (en) 1969-08-11
CY549A (en) 1970-08-03
DK116220B (en) 1969-12-22
ES293286A2 (en) 1964-04-16
BR6354399D0 (en) 1973-12-18
FR3208M (en) 1965-03-22
GB1067828A (en) 1967-05-03
LU44759A1 (en) 1964-05-06
MY7000175A (en) 1970-12-31
OA00701A (en) 1967-07-15

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