GB1060354A - Process for preparing 3-keto-í¸-steroids - Google Patents

Process for preparing 3-keto-í¸-steroids

Info

Publication number
GB1060354A
GB1060354A GB4066865A GB4066865A GB1060354A GB 1060354 A GB1060354 A GB 1060354A GB 4066865 A GB4066865 A GB 4066865A GB 4066865 A GB4066865 A GB 4066865A GB 1060354 A GB1060354 A GB 1060354A
Authority
GB
United Kingdom
Prior art keywords
keto
preparing
diol
steroids
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4066865A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US286959A external-priority patent/US3187025A/en
Priority claimed from US347399A external-priority patent/US3231568A/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB1060354A publication Critical patent/GB1060354A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises a process for preparing compounds of formula <FORM:1060354/C2/1> wherein R is a hydrogen atom or a methyl group or, in combination with the 17a -hydroxy group, a 16a ,17a -diol-16a ,17a -acetonide group, by reaction of a corresponding 3b -hydroxy-5,6-dibromopregnane, oxidizing this with Jones reagent to form a 3-keto-5,6-dibromo-pregnane, and debrominating this compound, followed if desired by acid isomersation. Pregn - 5 - em - 3b ,16a ,17a ,21 - tetrol - 20 - one-21 - acetate - 16,17 - acetonide is prepared by reaction of the 16a ,17a -diol with acetone.
GB4066865A 1963-06-11 1964-06-02 Process for preparing 3-keto-í¸-steroids Expired GB1060354A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US286959A US3187025A (en) 1963-06-11 1963-06-11 Process for preparing compound s
US347399A US3231568A (en) 1964-02-26 1964-02-26 Processes and intermediates for preparing 16alpha-methyl corticoids

Publications (1)

Publication Number Publication Date
GB1060354A true GB1060354A (en) 1967-03-01

Family

ID=26964160

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2285964A Expired GB1059643A (en) 1963-06-11 1964-06-02 Improvements in or relating to processes for preparing corticoid compounds
GB4066865A Expired GB1060354A (en) 1963-06-11 1964-06-02 Process for preparing 3-keto-í¸-steroids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2285964A Expired GB1059643A (en) 1963-06-11 1964-06-02 Improvements in or relating to processes for preparing corticoid compounds

Country Status (6)

Country Link
BE (1) BE649163A (en)
CH (1) CH433286A (en)
DE (1) DE1235907B (en)
GB (2) GB1059643A (en)
IT (2) IT1048877B (en)
NL (2) NL151088B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1060392B (en) * 1958-02-20 1959-07-02 Merck Ag E Process for the production of Reichsteins substance S
DE1060860B (en) * 1958-03-29 1959-07-09 Merck Ag E Process for the production of Reichsteins substance S

Also Published As

Publication number Publication date
NL6406306A (en) 1964-12-14
DE1235907B (en) 1967-03-09
NL151088B (en) 1976-10-15
NL6406303A (en) 1964-12-14
IT1048877B (en) 1980-12-20
IT1048876B (en) 1980-12-20
GB1059643A (en) 1967-02-22
CH433286A (en) 1967-04-15
BE649163A (en) 1964-12-11

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