GB1031082A - Benzene derivatives - Google Patents
Benzene derivativesInfo
- Publication number
- GB1031082A GB1031082A GB4664/64A GB466464A GB1031082A GB 1031082 A GB1031082 A GB 1031082A GB 4664/64 A GB4664/64 A GB 4664/64A GB 466464 A GB466464 A GB 466464A GB 1031082 A GB1031082 A GB 1031082A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- alkyl
- alkyl radical
- reaction
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Abstract
The invention comprises tetrafluorobenzene derivatives of the formula <FORM:1031082/C2/1> and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or an alkyl radical optionally bearing one or more hydroxy substituents, R2 is hydrogen or an alkyl or cycloalkyl radical or NR1R2 together form a heterocyclic radical optionally bearing one or more alkyl substituents, and R3 is hydrogen or an alkyl radical, but excluding 2,3,5,6-tetrafluoro-sulphanilamide and its pharmaceutically-acceptable salts. The compounds are made by reaction of the corresponding pentafluorobenzenesulphonamide with an amine NHR1R2 or, if desired, in the case where R1 is to be hydrogen and R2 and R3 the same alkyl radical, by reaction of a pentafluorosulphonyl halide with two equivalents of a monoalkylamine or, if R3 is to be an alkyl radical, by alkylating a tetrafluorobenzenesulphonamide, bearing a substituent NR1R2 in the 4-position. Pharmaceutical preparations having anti-convulsant activity comprise the above compounds of the invention in admixture with a diluent or carrier in forms suitable for oral, parenteral or rectal administration.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4664/64A GB1031082A (en) | 1964-02-04 | 1964-02-04 | Benzene derivatives |
| NL6501375A NL6501375A (en) | 1964-02-04 | 1965-02-03 | |
| BE659230A BE659230A (en) | 1964-02-04 | 1965-02-03 | |
| ES0308890A ES308890A1 (en) | 1964-02-04 | 1965-02-03 | Benzene derivatives |
| FR4432A FR1453262A (en) | 1964-02-04 | 1965-02-04 | Benzene derivatives |
| FR15584A FR4749M (en) | 1964-02-04 | 1965-05-03 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4664/64A GB1031082A (en) | 1964-02-04 | 1964-02-04 | Benzene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1031082A true GB1031082A (en) | 1966-05-25 |
Family
ID=9781462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4664/64A Expired GB1031082A (en) | 1964-02-04 | 1964-02-04 | Benzene derivatives |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE659230A (en) |
| ES (1) | ES308890A1 (en) |
| FR (2) | FR1453262A (en) |
| GB (1) | GB1031082A (en) |
| NL (1) | NL6501375A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014062044A1 (en) | 2012-10-15 | 2014-04-24 | Vilnius University | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
| US9422235B2 (en) | 2006-12-19 | 2016-08-23 | Pharmos Corporation | Sulfonamide derivatives with therapeutic indications |
-
1964
- 1964-02-04 GB GB4664/64A patent/GB1031082A/en not_active Expired
-
1965
- 1965-02-03 BE BE659230A patent/BE659230A/xx unknown
- 1965-02-03 NL NL6501375A patent/NL6501375A/xx unknown
- 1965-02-03 ES ES0308890A patent/ES308890A1/en not_active Expired
- 1965-02-04 FR FR4432A patent/FR1453262A/en not_active Expired
- 1965-05-03 FR FR15584A patent/FR4749M/fr not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422235B2 (en) | 2006-12-19 | 2016-08-23 | Pharmos Corporation | Sulfonamide derivatives with therapeutic indications |
| WO2014062044A1 (en) | 2012-10-15 | 2014-04-24 | Vilnius University | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
| LT6064B (en) | 2012-10-15 | 2014-08-25 | Vilniaus Universitetas | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
| US9725467B2 (en) | 2012-10-15 | 2017-08-08 | Vilnius University | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
Also Published As
| Publication number | Publication date |
|---|---|
| FR4749M (en) | 1967-01-16 |
| BE659230A (en) | 1965-08-03 |
| ES308890A1 (en) | 1965-12-16 |
| NL6501375A (en) | 1965-08-05 |
| FR1453262A (en) | 1966-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1120463A (en) | Derivatives of 1,3-diazafluoranthene-1-oxide | |
| GB1086191A (en) | Phenylcyclopropane derivatives | |
| ES346521A1 (en) | N-(sulfonylcarbamoyl)-bornano-(3',2':4,5)-oxazolidin-3-ones | |
| ES433148A1 (en) | Pyrazole derivatives | |
| GB1318291A (en) | Carboxamide derivatives and fungicidal compositions containing them | |
| GB1031082A (en) | Benzene derivatives | |
| GB1232836A (en) | ||
| GB1167711A (en) | Diarylcyclopropane Derivatives | |
| GB1033920A (en) | Novel derivatives of triphenylethanols | |
| ES447751A1 (en) | Imidazolyl-2-quinazoline derivatives | |
| GB1043158A (en) | Improvements in or relating to piperidylalkidene-5h-dibenzo(a,d)cycloheptenes | |
| GB799780A (en) | New n-alkyl-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides | |
| ES316314A1 (en) | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) | |
| GB1091109A (en) | New derivative of phenylbutazone and its preparation | |
| GB1026403A (en) | Derivatives of ª‡-tetronic acid | |
| GB933968A (en) | New phthalimide derivatives | |
| GB1172788A (en) | N-(Azabicycloalkylisopropyl)-Aminopyridine Derivatives | |
| GB964396A (en) | N-substituted tris-chloromethyl acetamides | |
| GB1088880A (en) | ª‡-cycloalkyleneimino-substituted esters | |
| GB1108060A (en) | Indole derivatives and a process for their production | |
| GB1028233A (en) | 5-aminodibenzocycloheptene derivatives | |
| GB1027894A (en) | Improvements in or relating to new pteridine derivatives | |
| GB1237034A (en) | Substituted indolines | |
| GB1452207A (en) | 2-2-thioethyl-4-carboxy thiazolidine derivatives | |
| GB799778A (en) | New n-alkyl-alkyl-piperidine-monocarboxylic acid amides and n-alkyl-alkyl-pyrrolidine-monocarboxylic acid amides |