GB1025564A - Benzofuran derivatives and process for their production - Google Patents
Benzofuran derivatives and process for their productionInfo
- Publication number
- GB1025564A GB1025564A GB48098/65A GB4809865A GB1025564A GB 1025564 A GB1025564 A GB 1025564A GB 48098/65 A GB48098/65 A GB 48098/65A GB 4809865 A GB4809865 A GB 4809865A GB 1025564 A GB1025564 A GB 1025564A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzofuran
- compound
- chloromethyl
- reaction
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
Abstract
Compounds of the general Formula II <FORM:1025564/C2/1> wherein R1 is methoxy or benzyloxy, R2 is a C1 to C5 alkyl, and R3 is hydrogen, carbethoxy, or an acyl group derived from a C1 to C5 aliphatic or aromatic carboxylic acid which is optionally substituted by hydroxy, C1 to C5 alkoxy, aralkoxy, amino or C1 to C5 alkyl, and the hydrochlorides thereof are prepared by reduction with an alkali metal aluminium hydride of a compound of the general Formula <FORM:1025564/C2/2> or a C1 to C5 ester thereof, to the correspondin 2-hydroxymethyl benzofuran, converting the latter into the corresponding 2-chloromethyl benzofuran by reaction with a chlorinating agent, reacting said 2-chloromethyl compound with a metal cyanide to form the corresponding 2-cyanomethyl benzofuran, reducing the 2-cyanomethyl compound with an alkali metal aluminium hydride to produce the corresponding 2 - (b - aminoethyl) - benzofuran, which is optionally isolated as a hydrochloride or the corresponding 2 - (b - acylaminoethyl) - benzofuran of Formula II is prepared by reaction with an aliphatic or aromatic carboxylic acid or the corresponding compound of Formula II, wherein R3 is carbethoxy is prepared by reaction with ethyl chlozoformaIe. The preferred chlorinating agent employed for the formation of 2-chloromethyl benzofuran is thionyl chloride in the presence of pyridine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB0064657 | 1961-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1025564A true GB1025564A (en) | 1966-04-14 |
Family
ID=6974466
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB37537/62A Expired GB1025563A (en) | 1961-11-03 | 1962-10-04 | Benzofuran derivatives and process for their production |
GB48098/65A Expired GB1025564A (en) | 1961-11-03 | 1962-10-04 | Benzofuran derivatives and process for their production |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB37537/62A Expired GB1025563A (en) | 1961-11-03 | 1962-10-04 | Benzofuran derivatives and process for their production |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB1025563A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2056441B (en) | 1979-07-26 | 1983-07-06 | Kyowa Hakko Kogyo Kk | Derivatives of benzo(b)furan and pharmaceutical compositions containing them |
-
1962
- 1962-10-04 GB GB37537/62A patent/GB1025563A/en not_active Expired
- 1962-10-04 GB GB48098/65A patent/GB1025564A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1025563A (en) | 1966-04-14 |
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