GB1021525A - New isoquinolines and process for preparing them - Google Patents

New isoquinolines and process for preparing them

Info

Publication number
GB1021525A
GB1021525A GB720464A GB720464A GB1021525A GB 1021525 A GB1021525 A GB 1021525A GB 720464 A GB720464 A GB 720464A GB 720464 A GB720464 A GB 720464A GB 1021525 A GB1021525 A GB 1021525A
Authority
GB
United Kingdom
Prior art keywords
isoquinoline
methyl
isoquinolines
preparing
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB720464A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH220563A external-priority patent/CH449013A/en
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1021525A publication Critical patent/GB1021525A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 1-morpholino-3-(morpholino - methyl) - 4 - methyl - isoquinoline, and salts thereof, and its preparation by reacting morpholine with a 4-methyl-3-morpholinomethyl - 1 - halo - isoquinoline (preferable in situ from a 4-methyl-3-halomethyl-1-halo-isoquinoline). Isoquinoline precursors also mentioned are 4-monomethyl-and 4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline. Pharmaceutical compositions incorporate compounds of the invention, forms for oral and parenteral administration as antitussives being described.
GB720464A 1963-02-21 1964-02-20 New isoquinolines and process for preparing them Expired GB1021525A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH220563A CH449013A (en) 1963-02-21 1963-02-21 Process for the preparation of new isoquinoline compounds
CH67164 1964-01-21
CH67264 1964-01-21

Publications (1)

Publication Number Publication Date
GB1021525A true GB1021525A (en) 1966-03-02

Family

ID=27172297

Family Applications (2)

Application Number Title Priority Date Filing Date
GB720564A Expired GB1021526A (en) 1963-02-21 1964-02-20 New isquinolines and process for preparing them
GB720464A Expired GB1021525A (en) 1963-02-21 1964-02-20 New isoquinolines and process for preparing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB720564A Expired GB1021526A (en) 1963-02-21 1964-02-20 New isquinolines and process for preparing them

Country Status (4)

Country Link
BE (2) BE644127A (en)
FR (2) FR3534M (en)
GB (2) GB1021526A (en)
NL (2) NL6401592A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7824661B2 (en) 2002-03-11 2010-11-02 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof
CA2478305C (en) 2002-03-11 2012-04-24 Biostream, Inc. Technetium-dipyridine complexes, and methods of use thereof
WO2005079865A1 (en) * 2004-02-12 2005-09-01 Molecular Insight Pharmaceuticals Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof

Also Published As

Publication number Publication date
FR3534M (en) 1965-09-13
NL6401593A (en) 1964-08-24
GB1021526A (en) 1966-03-02
FR3782M (en) 1965-12-27
NL6401592A (en) 1964-08-24
BE644127A (en) 1964-08-20
BE644126A (en) 1964-08-20

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