GB0922365D0 - Fistula grafts having a deflectable graft body portion - Google Patents

Fistula grafts having a deflectable graft body portion

Info

Publication number
GB0922365D0
GB0922365D0 GBGB0922365.2A GB0922365A GB0922365D0 GB 0922365 D0 GB0922365 D0 GB 0922365D0 GB 0922365 A GB0922365 A GB 0922365A GB 0922365 D0 GB0922365 D0 GB 0922365D0
Authority
GB
United Kingdom
Prior art keywords
graft body
condition
tether
distal end
deflectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GBGB0922365.2A
Other versions
GB2462575A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Biotech Inc
Original Assignee
Cook Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Biotech Inc filed Critical Cook Biotech Inc
Publication of GB0922365D0 publication Critical patent/GB0922365D0/en
Publication of GB2462575A publication Critical patent/GB2462575A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00641Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closing fistulae, e.g. anorectal fistulae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/00654Type of implements entirely comprised between the two sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00893Material properties pharmaceutically effective
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3983Reference marker arrangements for use with image guided surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)

Abstract

This invention provides, in certain aspects, unique devices and methods for treating fistulae. In one embodiment, an inventive device includes an elongate graft body having a proximal end and a distal end. The graft body is configurable to a first condition and a second condition, the second condition including the distal end deflected laterally relative to its position in the first condition of the body. The device also includes a tether, which is connected to the graft body, and is configured to traverse proximally along the body. The tether is manipulable to convert the graft body from the first condition to the second condition. Such a device may also include one or more additional tethers connected to the graft body. For instance, a second tether can be configured to extend distally from the distal end of the graft body, and may be effective in pulling the graft body along a fistula tract.
GB0922365A 2007-07-02 2009-12-22 Fistula grafts having a deflectable graft body portion Withdrawn GB2462575A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94757307P 2007-07-02 2007-07-02
US12/166,015 US8535349B2 (en) 2007-07-02 2008-07-01 Fistula grafts having a deflectable graft body portion
PCT/US2008/068984 WO2009006509A1 (en) 2007-07-02 2008-07-02 Fistula grafts having a deflectable graft body portion

Publications (2)

Publication Number Publication Date
GB0922365D0 true GB0922365D0 (en) 2010-02-03
GB2462575A GB2462575A (en) 2010-02-17

Family

ID=40222068

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0922365A Withdrawn GB2462575A (en) 2007-07-02 2009-12-22 Fistula grafts having a deflectable graft body portion

Country Status (5)

Country Link
US (1) US8535349B2 (en)
AU (1) AU2008272864A1 (en)
CA (1) CA2690957A1 (en)
GB (1) GB2462575A (en)
WO (1) WO2009006509A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2193749B1 (en) 2004-01-21 2017-03-01 Cook Medical Technologies LLC Implantable graft to close a fistula
US8863772B2 (en) * 2008-08-27 2014-10-21 Deka Products Limited Partnership Occluder for a medical infusion system
US7905381B2 (en) * 2008-09-19 2011-03-15 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with cutting member arrangement
GB2471635B (en) * 2008-05-29 2012-09-26 Cook Biotech Inc Devices for treating rectovaginal and other fistulae
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
US20110087274A1 (en) * 2009-10-08 2011-04-14 Tyco Healtcare Group LP, New Haven, Ct Wound Closure Device
US8617206B2 (en) * 2009-10-08 2013-12-31 Covidien Lp Wound closure device
US20110087273A1 (en) * 2009-10-08 2011-04-14 Tyco Healthcare Group Lp Wound Closure Device
US9833225B2 (en) * 2009-10-08 2017-12-05 Covidien Lp Wound closure device
US8858592B2 (en) 2009-11-24 2014-10-14 Covidien Lp Wound plugs
EP2729210B1 (en) 2011-07-08 2017-11-08 C.R. Bard Inc. Implantable prosthesis for fistula repair
WO2013016275A1 (en) 2011-07-22 2013-01-31 Cook Medical Technologies Llc Irrigation devices adapted to be used with a light source for the identification and treatment of bodily passages
US10130346B2 (en) * 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
US9314593B2 (en) 2012-09-24 2016-04-19 Cook Medical Technologies Llc Medical devices for the identification and treatment of bodily passages
US10314736B2 (en) 2012-10-16 2019-06-11 Cook Medical Technologies Llc Method and apparatus for treating obstructive sleep apnea (OSA)
US9895055B2 (en) 2013-02-28 2018-02-20 Cook Medical Technologies Llc Medical devices, systems, and methods for the visualization and treatment of bodily passages
US9549748B2 (en) 2013-08-01 2017-01-24 Cook Medical Technologies Llc Methods of locating and treating tissue in a wall defining a bodily passage
JP6364078B2 (en) 2013-08-05 2018-07-25 クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーCook Medical Technologies Llc Medical device having releasable tubular member and method of using the same
US9956384B2 (en) 2014-01-24 2018-05-01 Cook Medical Technologies Llc Articulating balloon catheter and method for using the same
US9937323B2 (en) 2014-02-28 2018-04-10 Cook Medical Technologies Llc Deflectable catheters, systems, and methods for the visualization and treatment of bodily passages
US9974563B2 (en) 2014-05-28 2018-05-22 Cook Medical Technologies Llc Medical devices having a releasable member and methods of using the same
WO2016022454A1 (en) 2014-08-04 2016-02-11 Darin Schaeffer Medical devices having a releasable tubular member and methods of using the same
US10195398B2 (en) 2014-08-13 2019-02-05 Cook Medical Technologies Llc Tension member seal and securing mechanism for medical devices
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10028733B2 (en) 2015-05-28 2018-07-24 National University Of Ireland, Galway Fistula treatment device
US11701096B2 (en) 2015-05-28 2023-07-18 National University Of Ireland, Galway Fistula treatment device
EP3290062A1 (en) * 2016-08-31 2018-03-07 B. Braun Surgical, S.A. Medical device, in particular for treating fistulas
CN110740692B (en) 2017-06-09 2023-07-14 希格纳姆外科有限公司 Implant for closing an opening in tissue
US11826490B1 (en) 2020-12-29 2023-11-28 Acell, Inc. Extracellular matrix sheet devices with improved mechanical properties and method of making

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2127903A (en) 1936-05-05 1938-08-23 Davis & Geck Inc Tube for surgical purposes and method of preparing and using the same
FR2516927B1 (en) 1981-11-26 1986-05-23 Merieux Fond PROCESS FOR THE INDUSTRIAL PREPARATION OF COLLAGENIC MATERIALS FROM HUMAN PLACENTARY TISSUES, HUMAN COLLAGENIC MATERIALS OBTAINED, THEIR APPLICATION AS BIOMATERIALS
DK153122C (en) 1985-01-15 1988-11-14 Coloplast As CLOSURE FOR SINGLE USE FOR AN ARTIFICIAL OR INCONTINENT NATURAL TREATMENT
USRE34866E (en) 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5374261A (en) 1990-07-24 1994-12-20 Yoon; Inbae Multifunctional devices for use in endoscopic surgical procedures and methods-therefor
SU1673130A1 (en) 1988-12-21 1991-08-30 Центральный институт усовершенствования врачей Device for closing external intestinal fistula
US5620461A (en) 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
SU1718837A1 (en) 1989-11-13 1992-03-15 Днепропетровский Научно-Исследовательский Институт Восстановления И Экспертизы Трудоспособности Инвалидов Method for obturation of large intestine fistulae
CA2122041A1 (en) 1989-12-04 1993-04-29 Kenneth Kensey Plug device for sealing openings and method of use
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5104332A (en) 1991-01-22 1992-04-14 Group Dekko International Modular furniture power distribution system and electrical connector therefor
US5222970A (en) 1991-09-06 1993-06-29 William A. Cook Australia Pty. Ltd. Method of and system for mounting a vascular occlusion balloon on a delivery catheter
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5304123A (en) 1991-10-24 1994-04-19 Children's Medical Center Corporation Detachable balloon catheter for endoscopic treatment of vesicoureteral reflux
US5584827A (en) 1992-05-18 1996-12-17 Ultracell Medical Technologies, Inc Nasal-packing article
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
US5643305A (en) 1994-11-18 1997-07-01 Al-Tameem; Moshin Device for excision of a fistula
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
WO1996032153A1 (en) 1995-04-14 1996-10-17 Interventional Therapeutics Corporation Dual valve detachable occlusion balloon and over-the-wire delivery apparatus and method for use therewith
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US5830228A (en) 1996-05-29 1998-11-03 Urosurge, Inc. Methods and systems for deployment of a detachable balloon at a target site in vivo
ES2208974T3 (en) 1996-08-23 2004-06-16 Cook Biotech, Inc. PROTESIS OF GRAFT, MATERIALS AND METHODS.
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
CA2274033C (en) 1996-12-10 2010-05-11 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
WO1998025636A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Stomach submucosa derived tissue graft
CA2272097C (en) 1996-12-10 2007-02-20 Purdue Research Foundation Artificial vascular valves
US6375989B1 (en) 1996-12-10 2002-04-23 Purdue Research Foundation Submucosa extracts
US8323305B2 (en) 1997-02-11 2012-12-04 Cardiva Medical, Inc. Expansile device for use in blood vessels and tracts in the body and method
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6095383A (en) 1997-10-31 2000-08-01 Fata Hunter, Inc. Adjustable molten metal feed system
AUPP633798A0 (en) 1998-10-02 1998-10-29 White, Geoffrey H. Device for the occlusion of a puncture in a bodily duct
US6080183A (en) 1998-11-24 2000-06-27 Embol-X, Inc. Sutureless vessel plug and methods of use
ATE410119T1 (en) 1998-12-01 2008-10-15 Univ Washington DEVICE FOR INTRAVASCULAR EMBOLIZATION
DK173680B1 (en) 1999-02-10 2001-06-11 Coloplast As ostomy Prop
US6482179B1 (en) 1999-05-28 2002-11-19 Cohesion Technologies, Inc. Apparatuses, methods and compositions for closing tissue puncture openings
DE29909888U1 (en) 1999-06-07 2000-10-19 Novomed Gmbh Fistula blocker
RU2180529C2 (en) 1999-08-02 2002-03-20 Областная клиническая больница № 1 Свердловской области Method for extraperitoneally closing formed intestinal fistulae
WO2001054593A1 (en) 2000-01-31 2001-08-02 The General Hospital Corporation Neural regeneration conduit
US20060004408A1 (en) 2001-06-08 2006-01-05 Morris Edward J Method and apparatus for sealing access
AU2002320182B2 (en) 2001-06-29 2008-02-21 Cook Biotech Incorporated Porous sponge matrix medical devices and methods
US8465516B2 (en) 2001-07-26 2013-06-18 Oregon Health Science University Bodily lumen closure apparatus and method
EP1408847B1 (en) 2001-07-26 2005-05-04 Oregon Health Sciences University Vessel closure member and delivery apparatus
US7101381B2 (en) 2002-08-02 2006-09-05 C.R. Bard, Inc. Implantable prosthesis
TR200202198A2 (en) 2002-09-13 2004-04-21 Zafer Malazgirt Patch-plug used to repair large trocar holes after laparoscopic surgery
US8021692B2 (en) 2003-08-25 2011-09-20 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture
NL1024218C2 (en) 2003-09-03 2005-03-07 Stichting Sint Annadal Device for treating fistulas.
US7645229B2 (en) 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
EP2193749B1 (en) 2004-01-21 2017-03-01 Cook Medical Technologies LLC Implantable graft to close a fistula
AR043363A1 (en) 2004-02-13 2005-07-27 Rafael Carmelo Antonio Perrone PROTESIS FOR AERO-DIGESTIVE FISTULAS
JP4366306B2 (en) 2004-12-17 2009-11-18 テルモ株式会社 In vivo tissue closure device and in vivo tissue closure device
CA2606445C (en) 2005-04-29 2014-09-16 Cook Biotech Incorporated Volumetric grafts for treatment of fistulae and related methods and systems
US9956315B2 (en) 2005-04-29 2018-05-01 Cook Biotech Incorporated Fistula graft with deformable sheet-form material
JP2008543504A (en) 2005-06-21 2008-12-04 クック・インコーポレイテッド Implantable graft to close the fistula
US20070129757A1 (en) 2005-12-02 2007-06-07 Cook Incorporated Devices, systems, and methods for occluding a defect
AU2007210970B2 (en) 2006-01-31 2013-09-05 Cook Biotech Incorporated Fistula grafts and related methods and systems for treating fistulae
AU2007210975A1 (en) 2006-01-31 2007-08-09 Cook Biotech Incorporated Fistula graft deployment systems and methods

Also Published As

Publication number Publication date
WO2009006509A1 (en) 2009-01-08
AU2008272864A1 (en) 2009-01-08
CA2690957A1 (en) 2009-01-08
US20090012558A1 (en) 2009-01-08
US8535349B2 (en) 2013-09-17
GB2462575A (en) 2010-02-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)