GB0808029D0 - Antifungal target - Google Patents

Antifungal target

Info

Publication number
GB0808029D0
GB0808029D0 GBGB0808029.3A GB0808029A GB0808029D0 GB 0808029 D0 GB0808029 D0 GB 0808029D0 GB 0808029 A GB0808029 A GB 0808029A GB 0808029 D0 GB0808029 D0 GB 0808029D0
Authority
GB
United Kingdom
Prior art keywords
antifungal target
antifungal
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0808029.3A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F2G Ltd
Original Assignee
F2G Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F2G Ltd filed Critical F2G Ltd
Priority to GBGB0808029.3A priority Critical patent/GB0808029D0/en
Publication of GB0808029D0 publication Critical patent/GB0808029D0/en
Priority to NZ588703A priority patent/NZ588703A/en
Priority to AU2009241646A priority patent/AU2009241646B2/en
Priority to PCT/GB2009/001114 priority patent/WO2009133379A2/en
Priority to CA2721959A priority patent/CA2721959A1/en
Priority to US12/990,478 priority patent/US9034887B2/en
Priority to EP09738409.3A priority patent/EP2283151B1/en
Priority to JP2011506773A priority patent/JP5901967B2/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/001Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y103/00Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/05Oxidoreductases acting on the CH-CH group of donors (1.3) with a quinone or related compound as acceptor (1.3.5)
    • C12Y103/05002Dihydroorotate dehydrogenase (1.3.5.2)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/90206Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
GBGB0808029.3A 2008-05-01 2008-05-01 Antifungal target Ceased GB0808029D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GBGB0808029.3A GB0808029D0 (en) 2008-05-01 2008-05-01 Antifungal target
NZ588703A NZ588703A (en) 2008-05-01 2009-05-01 Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof
AU2009241646A AU2009241646B2 (en) 2008-05-01 2009-05-01 Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof
PCT/GB2009/001114 WO2009133379A2 (en) 2008-05-01 2009-05-01 Antifungal target
CA2721959A CA2721959A1 (en) 2008-05-01 2009-05-01 A method of identifying an antifungal target to dihydroorotate dehydrogenase
US12/990,478 US9034887B2 (en) 2008-05-01 2009-05-01 Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof
EP09738409.3A EP2283151B1 (en) 2008-05-01 2009-05-01 Dihydroorotate dehydrogenase as antifungal drug target
JP2011506773A JP5901967B2 (en) 2008-05-01 2009-05-01 Dihydroorotate dehydrogenase and its quinazolinone inhibitors as targets for antifungal agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0808029.3A GB0808029D0 (en) 2008-05-01 2008-05-01 Antifungal target

Publications (1)

Publication Number Publication Date
GB0808029D0 true GB0808029D0 (en) 2008-06-11

Family

ID=39537191

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0808029.3A Ceased GB0808029D0 (en) 2008-05-01 2008-05-01 Antifungal target

Country Status (8)

Country Link
US (1) US9034887B2 (en)
EP (1) EP2283151B1 (en)
JP (1) JP5901967B2 (en)
AU (1) AU2009241646B2 (en)
CA (1) CA2721959A1 (en)
GB (1) GB0808029D0 (en)
NZ (1) NZ588703A (en)
WO (1) WO2009133379A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8686048B2 (en) 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
US20140031383A1 (en) 2011-02-08 2014-01-30 Dana-Farber Cancer Institute, Inc. Methods for treatment of melanoma
SG11201702516UA (en) 2014-10-23 2017-04-27 Sanofi Sa Novel selection marker for cell transfection and protein production
ES2544519B1 (en) * 2015-05-22 2016-03-04 Consejo Superior De Investigaciones Científicas (Csic) S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976848A (en) * 1990-08-03 1999-11-02 Dow Agrosciences Llc Method of identifying potential fungicides using dihydroorotate dehydrogenase inhibition assay
US6951847B2 (en) * 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
WO2002086090A2 (en) * 2001-04-23 2002-10-31 Elitra Pharmaceuticals, Inc. Identification of essential genes of aspegillus fumigatus and methods of use

Also Published As

Publication number Publication date
AU2009241646B2 (en) 2015-02-05
WO2009133379A8 (en) 2010-02-25
NZ588703A (en) 2012-10-26
WO2009133379A3 (en) 2009-12-23
EP2283151B1 (en) 2017-03-08
AU2009241646A1 (en) 2009-11-05
US20110160231A1 (en) 2011-06-30
US9034887B2 (en) 2015-05-19
JP2011520431A (en) 2011-07-21
WO2009133379A2 (en) 2009-11-05
CA2721959A1 (en) 2009-11-05
EP2283151A2 (en) 2011-02-16
JP5901967B2 (en) 2016-04-13

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)