FR3078541B1 - Modele d’injection sous-cutanee ex vivo - Google Patents

Modele d’injection sous-cutanee ex vivo Download PDF

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Publication number
FR3078541B1
FR3078541B1 FR1870232A FR1870232A FR3078541B1 FR 3078541 B1 FR3078541 B1 FR 3078541B1 FR 1870232 A FR1870232 A FR 1870232A FR 1870232 A FR1870232 A FR 1870232A FR 3078541 B1 FR3078541 B1 FR 3078541B1
Authority
FR
France
Prior art keywords
subcutaneous injection
injection model
vivo subcutaneous
vivo
model
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1870232A
Other languages
English (en)
Other versions
FR3078541A1 (fr
Inventor
Emeline Pages
Claire Jardet
Pascal Descargues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genoskin SAS
Original Assignee
Genoskin SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1870232A priority Critical patent/FR3078541B1/fr
Application filed by Genoskin SAS filed Critical Genoskin SAS
Priority to EP19711245.1A priority patent/EP3762481A1/fr
Priority to PCT/EP2019/000061 priority patent/WO2019170281A1/fr
Priority to US16/971,599 priority patent/US20200400652A1/en
Priority to KR1020207028321A priority patent/KR20200128124A/ko
Priority to CA3091505A priority patent/CA3091505A1/fr
Priority to SG11202010680QA priority patent/SG11202010680QA/en
Priority to JP2020544812A priority patent/JP7361039B2/ja
Publication of FR3078541A1 publication Critical patent/FR3078541A1/fr
Application granted granted Critical
Publication of FR3078541B1 publication Critical patent/FR3078541B1/fr
Active legal-status Critical Current
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698Skin equivalents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/0231Chemically defined matrices, e.g. alginate gels, for immobilising, holding or storing cells, tissue or organs for preservation purposes; Chemically altering or fixing cells, tissue or organs, e.g. by cross-linking, for preservation purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • C12M25/04Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/12Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14Calcium; Ca chelators; Calcitonin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/76Agarose, agar-agar

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR1870232A 2018-03-05 2018-03-05 Modele d’injection sous-cutanee ex vivo Active FR3078541B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1870232A FR3078541B1 (fr) 2018-03-05 2018-03-05 Modele d’injection sous-cutanee ex vivo
PCT/EP2019/000061 WO2019170281A1 (fr) 2018-03-05 2019-03-03 Modele d'injection sous cutanee ex vivo
US16/971,599 US20200400652A1 (en) 2018-03-05 2019-03-03 Ex vivo subcutaneous injection model
KR1020207028321A KR20200128124A (ko) 2018-03-05 2019-03-03 엑스 비보 피하 주사 모형
EP19711245.1A EP3762481A1 (fr) 2018-03-05 2019-03-03 Modele d'injection sous cutanee ex vivo
CA3091505A CA3091505A1 (fr) 2018-03-05 2019-03-03 Modele d'injection sous cutanee ex vivo
SG11202010680QA SG11202010680QA (en) 2018-03-05 2019-03-03 Ex vivo subcutaneous injection model
JP2020544812A JP7361039B2 (ja) 2018-03-05 2019-03-03 エキソビボ皮下注入モデル

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1870232A FR3078541B1 (fr) 2018-03-05 2018-03-05 Modele d’injection sous-cutanee ex vivo
FR1870232 2018-03-05

Publications (2)

Publication Number Publication Date
FR3078541A1 FR3078541A1 (fr) 2019-09-06
FR3078541B1 true FR3078541B1 (fr) 2022-07-08

Family

ID=63638116

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1870232A Active FR3078541B1 (fr) 2018-03-05 2018-03-05 Modele d’injection sous-cutanee ex vivo

Country Status (8)

Country Link
US (1) US20200400652A1 (fr)
EP (1) EP3762481A1 (fr)
JP (1) JP7361039B2 (fr)
KR (1) KR20200128124A (fr)
CA (1) CA3091505A1 (fr)
FR (1) FR3078541B1 (fr)
SG (1) SG11202010680QA (fr)
WO (1) WO2019170281A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230101335A1 (en) 2021-05-06 2023-03-30 Massachusetts Institute Of Technology Ex vivo tissue explant and graft platform and uses thereof
FR3123125A1 (fr) 2021-05-20 2022-11-25 Genoskin Modèle humain ex vivo destiné à l’évaluation du potentiel inflammatoire de type allergique ou pseudo-allergique
CA3228315A1 (fr) * 2021-08-20 2023-02-23 Marisa JOUBERT Methodes faisant appel a des composes therapeutiques et a une peau de mammifere in vitro
FR3132146A1 (fr) 2022-01-27 2023-07-28 Genoskin Modèle humain ex vivo destiné à l’évaluation du potentiel vaccinal d’une composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
FR2967163A1 (fr) * 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
FR2990106B1 (fr) * 2012-05-03 2014-05-09 Genoskin Systeme permettant la maintenance en survie et le transport de biospsies de peau et ses applications
CN105050580B (zh) * 2013-03-15 2017-11-28 玫琳凯有限公司 化妆品组合物及其用途
FR3032446B1 (fr) * 2015-02-10 2018-11-02 Genoskin Procede d implantation d amas cellulaires dans un explant de peau

Also Published As

Publication number Publication date
JP7361039B2 (ja) 2023-10-13
JP2021516542A (ja) 2021-07-08
US20200400652A1 (en) 2020-12-24
SG11202010680QA (en) 2020-11-27
WO2019170281A1 (fr) 2019-09-12
CA3091505A1 (fr) 2019-09-12
EP3762481A1 (fr) 2021-01-13
KR20200128124A (ko) 2020-11-11
FR3078541A1 (fr) 2019-09-06

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