FR3077823B1 - Procede de preparation d'un lysat plaquettaire irradie - Google Patents
Procede de preparation d'un lysat plaquettaire irradie Download PDFInfo
- Publication number
- FR3077823B1 FR3077823B1 FR1851307A FR1851307A FR3077823B1 FR 3077823 B1 FR3077823 B1 FR 3077823B1 FR 1851307 A FR1851307 A FR 1851307A FR 1851307 A FR1851307 A FR 1851307A FR 3077823 B1 FR3077823 B1 FR 3077823B1
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- Prior art keywords
- factor
- platelet lysate
- starting
- irradated
- preparing
- Prior art date
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- 238000000034 method Methods 0.000 title abstract 2
- 239000006166 lysate Substances 0.000 abstract 5
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 3
- 239000003114 blood coagulation factor Substances 0.000 abstract 3
- 230000005865 ionizing radiation Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 1
- 102100023804 Coagulation factor VII Human genes 0.000 abstract 1
- 108010076282 Factor IX Proteins 0.000 abstract 1
- 108010023321 Factor VII Proteins 0.000 abstract 1
- 108010014173 Factor X Proteins 0.000 abstract 1
- 108010074864 Factor XI Proteins 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010094028 Prothrombin Proteins 0.000 abstract 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 abstract 1
- 229960004222 factor ix Drugs 0.000 abstract 1
- 229940012413 factor vii Drugs 0.000 abstract 1
- 229940012426 factor x Drugs 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6443—Coagulation factor XIa (3.4.21.27)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/022—Filtration
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
- C12N2529/10—Stimulation by light
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procédé de préparation d'un lysat plaquettaire irradié comprenant les étapes suivantes : - la fourniture d'un lysat plaquettaire de départ comprenant d'une part des facteurs plaquettaires incluant des facteurs de croissance et d'autre part des protéines plasmatiques incluant des facteurs de coagulation et des protéines autres que les facteurs de coagulation, - la double irradiation dudit lysat plaquettaire de départ, par un rayonnement UVC et par un rayonnement ionisant, ladite double irradiation par rayonnement UVC et par rayonnement ionisant étant agencée pour conserver au moins 75% de la concentration en protéines totales dudit lysat plaquettaire de départ tout en réduisant d'au moins 40% la concentration en au moins un desdits facteurs de coagulation incluant le fibrinogène, le facteur II, le facteur VII, le facteur IX, le facteur X et le facteur XI du lysat plaquettaire de départ.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1851307A FR3077823B1 (fr) | 2018-02-15 | 2018-02-15 | Procede de preparation d'un lysat plaquettaire irradie |
EP19705334.1A EP3752207A1 (fr) | 2018-02-15 | 2019-02-12 | Procédé de préparation d'un lysat plaquettaire irradié |
PCT/EP2019/053472 WO2019158540A1 (fr) | 2018-02-15 | 2019-02-12 | Procédé de préparation d'un lysat plaquettaire irradié |
US16/969,600 US20210032590A1 (en) | 2018-02-15 | 2019-02-12 | Method for preparing an irradiated platelet lysate |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1851307 | 2018-02-15 | ||
FR1851307A FR3077823B1 (fr) | 2018-02-15 | 2018-02-15 | Procede de preparation d'un lysat plaquettaire irradie |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3077823A1 FR3077823A1 (fr) | 2019-08-16 |
FR3077823B1 true FR3077823B1 (fr) | 2022-01-14 |
Family
ID=62683308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1851307A Active FR3077823B1 (fr) | 2018-02-15 | 2018-02-15 | Procede de preparation d'un lysat plaquettaire irradie |
Country Status (4)
Country | Link |
---|---|
US (1) | US20210032590A1 (fr) |
EP (1) | EP3752207A1 (fr) |
FR (1) | FR3077823B1 (fr) |
WO (1) | WO2019158540A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2069479A1 (fr) | 2006-09-18 | 2009-06-17 | Medizinische Universität Graz | Lysat de plaquettes exempt de plasma destiné à être utilisé comme supplément dans des cultures cellulaires et pour la préparation de produits thérapeutiques cellulaires |
EP2334785B2 (fr) * | 2008-09-16 | 2019-08-14 | Mayo Foundation For Medical Education And Research | Compositions à contenu plaquettaire |
IL210162A0 (en) | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
EP2723354B3 (fr) | 2011-06-27 | 2021-03-24 | Emory University | Compositions, utilisations et préparation de lysats de plaquettes |
ITRM20110500A1 (it) * | 2011-09-23 | 2013-03-24 | Futura Stem Cells Sa | Lisato piastrinico, usi di esso e metodo per la sua preparazione |
EP2733200A1 (fr) * | 2012-11-15 | 2014-05-21 | Biorigen International SA | Suppléments de culture cellulaire |
FR3036707B1 (fr) * | 2015-05-29 | 2019-05-17 | Maco Pharma | Procede de sterilisation d'un lysat plaquettaire |
TWI744300B (zh) | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
-
2018
- 2018-02-15 FR FR1851307A patent/FR3077823B1/fr active Active
-
2019
- 2019-02-12 US US16/969,600 patent/US20210032590A1/en active Pending
- 2019-02-12 EP EP19705334.1A patent/EP3752207A1/fr active Pending
- 2019-02-12 WO PCT/EP2019/053472 patent/WO2019158540A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP3752207A1 (fr) | 2020-12-23 |
FR3077823A1 (fr) | 2019-08-16 |
WO2019158540A1 (fr) | 2019-08-22 |
US20210032590A1 (en) | 2021-02-04 |
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PLFP | Fee payment |
Year of fee payment: 2 |
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PLSC | Publication of the preliminary search report |
Effective date: 20190816 |
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Year of fee payment: 3 |
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Year of fee payment: 4 |
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