FR3040624A1 - COMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND LACTIC ACID - Google Patents
COMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND LACTIC ACID Download PDFInfo
- Publication number
- FR3040624A1 FR3040624A1 FR1558386A FR1558386A FR3040624A1 FR 3040624 A1 FR3040624 A1 FR 3040624A1 FR 1558386 A FR1558386 A FR 1558386A FR 1558386 A FR1558386 A FR 1558386A FR 3040624 A1 FR3040624 A1 FR 3040624A1
- Authority
- FR
- France
- Prior art keywords
- probiotic
- composition
- composition according
- lactic acid
- prebiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000006041 probiotic Substances 0.000 title claims abstract description 33
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 33
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 28
- 235000013406 prebiotics Nutrition 0.000 title claims abstract description 25
- 239000004310 lactic acid Substances 0.000 title claims abstract description 18
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 18
- 230000021332 multicellular organism growth Effects 0.000 claims abstract description 3
- 239000006166 lysate Substances 0.000 claims description 6
- 229920001542 oligosaccharide Polymers 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- 229920001202 Inulin Polymers 0.000 claims description 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 3
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
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- 150000003271 galactooligosaccharides Chemical class 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
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- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
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- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
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- 244000199866 Lactobacillus casei Species 0.000 description 1
- 241000186606 Lactobacillus gasseri Species 0.000 description 1
- 241000186605 Lactobacillus paracasei Species 0.000 description 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 244000183278 Nephelium litchi Species 0.000 description 1
- 235000015742 Nephelium litchi Nutrition 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000004904 UV filter Substances 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
- 229940064062 alpha-glucan oligosaccharide Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
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- 150000008366 benzophenones Chemical class 0.000 description 1
- 102000012265 beta-defensin Human genes 0.000 description 1
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- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
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- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical class C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 description 1
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- 229920013818 hydroxypropyl guar gum Polymers 0.000 description 1
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
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- 230000001333 moisturizer Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920013639 polyalphaolefin Polymers 0.000 description 1
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- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une composition comprenant, en association : - au moins un prébiotique ; - au moins une fraction probiotique ; et - de l'acide lactique. Elle concerne également l'utilsiation d'une composition selon l'invention en tant que produit destiné à une application sur les phanères notamment la peau.The invention relates to a composition comprising, in combination: - at least one prebiotic; at least one probiotic fraction; and - lactic acid. It also relates to the use of a composition according to the invention as a product intended for application to superficial body growths, in particular the skin.
Description
COMPOSITIONS COMPRENANT EN ASSOCIATION DES PREBIOTIQUES, DES FRACTIONS PROBIOTIQUES ET DE L'ACIDECOMPOSITIONS COMPRISING IN ASSOCIATION PREBIOTICS, PROBIOTIC FRACTIONS AND ACID
LACTIQUELACTIC
[0001] La présente invention concerne des compositions destinées à une application cutanée comprenant, en association : - des prébiotiques ; - des fractions probiotiques ; et - de l'acide lactique.The present invention relates to compositions for a cutaneous application comprising, in combination: - prebiotics; - probiotic fractions; and - lactic acid.
[0002] Cette association permet une triple action sur le microbiome cutané : - apport de nutriments aux bonnes bactéries cutanées avec les prébiotiques ; - stimulation du système immunitaire de la peau avec les fractions probiotiques ; et - soin de la peau tout en créant un milieu optimal aux bonnes bactéries grâce à l'acide lactique.This combination allows a triple action on the skin microbiome: - supply of nutrients to good skin bacteria with prebiotics; - stimulation of the immune system of the skin with probiotic fractions; and - skin care while creating an optimal environment for good bacteria thanks to lactic acid.
[0003] On entend par « prébiotique » un ingrédient alimentaire non-digestible qui affecte de façon bénéficiaire l'hôte en stimulant la croissance et/ou l'activité d'une ou d'un nombre limité de bactéries du colon. Cette définition de 1995 a été affinée en 2004 avec les trois caractéristiques suivantes : - résistance à l'acidité gastrique, à l'hydrolyse par les enzymes des mammifères et l'absorption gastro-intestinale ; - fermentation par la microflore intestinale ; - stimule sélective de la croissance et/ou de l'activité des bactéries intestinales associées à la santé et au bien-être.[0003] "Prebiotic" is understood to mean a non-digestible food ingredient beneficially affecting the host by stimulating the growth and / or activity of one or a limited number of colon bacteria. This 1995 definition was refined in 2004 with the following three characteristics: - resistance to gastric acidity, hydrolysis by mammalian enzymes and gastrointestinal absorption; - fermentation by intestinal microflora; - selectively stimulates the growth and / or activity of intestinal bacteria associated with health and well-being.
[0004] Les prébiotiques sont tous des sucres, ils sont considérés comme des fibres non digestibles et on peut les classer en fonction de leur degré de polymérisation : monosaccharides ; [0005] On y trouve par exemple le Tagatose, qui est naturellement présent en petites quantités dans la nature, et qui peut être produit à partir du lactose par isomérisation du galactose. Surtout reconnu pour ses propriétés sucrantes et antidiabétiques, il est aussi dégradé par certaines bactéries de l'intestin de genre Enterococcus and Lactobacillus. - disaccharides ; [0006] On y trouve par exemple le lactulose. Composé d'un fructose et d'un galactose, c'est un produit naturel dérivé du traitement du lait par haute température. Les études montrent une activité prébiotique sur les bactéries de type Bifidus, mais il est commercialisé principalement pour ses qualités de laxatif osmotique. - oligosaccharides ; [0007] Le plus commun est l'Inuline, un polymère d'oligofructose (abrégé en FOS pour Fructo-oligosaccharides) naturellement présent dans la nature. En fonction du degré de polymérisation on peut aussi parler d'oligofructose.Prebiotics are all sugars, they are considered as non-digestible fibers and can be classified according to their degree of polymerization: monosaccharides; There is for example Tagatose, which is naturally present in small amounts in nature, and which can be produced from lactose by isomerization of galactose. Mostly known for its sweetening and antidiabetic properties, it is also degraded by certain enterococcus and Lactobacillus bacteria. - disaccharides; There is for example lactulose. Composed of a fructose and a galactose, it is a natural product derived from the treatment of milk by high temperature. Studies show prebiotic activity on Bifidus bacteria, but it is marketed primarily for its osmotic laxative qualities. oligosaccharides; The most common is Inulin, an oligofructose polymer (abbreviated FOS for Fructo-oligosaccharides) naturally present in nature. Depending on the degree of polymerization one can also speak of oligofructose.
[0008] On trouve aussi d'autres oligosaccharides, comme les Transgalactooligosaccharides (TOS) : mélange d'oligosaccharides dérivés du lactose par transglycosylation enzymatique. Leur contenu précis dépend des saccharides d'origine et des enzymes utilisées. Généralement, ce sont des tri-, tétra- ou pentasaccharides : polydextrose, Galactooligosaccharides (GOS) qui sont présents naturellement par exemple dans le colostrum et le lait maternel.There are also other oligosaccharides, such as Transgalactooligosaccharides (TOS): a mixture of oligosaccharides derived from lactose by enzymatic transglycosylation. Their precise content depends on the original saccharides and the enzymes used. Generally, they are tri-, tetra- or pentasaccharides: polydextrose, Galactooligosaccharides (GOS) which are naturally present for example in colostrum and breast milk.
[0009] On entend par « probiotique » des micro-organismes vivants qui, quand ils sont administrés en quantités adéquates, confèrent un bénéfice de santé à leur hôte. Il est important de noter que des organismes morts, même si ils peuvent avoir une activité, ne devraient pas être appelés probiotiques.[0009] "Probiotic" is understood to mean living microorganisms which, when they are administered in adequate quantities, confer a health benefit on their host. It is important to note that dead organisms, even though they may have activity, should not be called probiotics.
[00010] Les probiotiques peuvent être des bactéries ou des levures.Probiotics can be bacteria or yeasts.
[00011] Bactéries : genres Lactobacillus et Bifidobacterium. Les souches identifiées comme probiotiques s'appliquent principalement à la sphère intestinale, il s'agit notamment de, respectivement, Lactobacillus acidophilus, L. casei, L. gasseri, L. paracasei, L. Rhamnosus et Bifidobacteria animal, B. breve, B. longum. - Levures : Saccharomyces cerevisiae var. boulardii qui se trouvent de façon naturelle dans le litchi.Bacteria: genera Lactobacillus and Bifidobacterium. The strains identified as probiotic apply mainly to the intestinal sphere, these include, respectively, Lactobacillus acidophilus, L. casei, L. gasseri, L. paracasei, L. Rhamnosus and Bifidobacteria animal, B. breve, B longum. - Yeasts: Saccharomyces cerevisiae var. boulardii found naturally in the lychee.
[00012] On entend par « synbiotique » un mélange de prébiotiques et de probiotiques. Puisque le terme évoque la synergie, il ne doit être utilisé que quand l'action de ce prébiotique précis stimule la croissance des probiotiques du mélange.By "synbiotic" is meant a mixture of prebiotics and probiotics. Since the term evokes synergy, it should only be used when the action of this precise prebiotic stimulates the growth of the probiotics of the mixture.
[00013] L'acide lactique peut être considéré comme un « postbiotique », terme utilisé pour définir des produits bactériens ou des métabolites d'organismes probiotiques qui ont une activité biologique sur l'hôte. L'acide lactique fait partie du groupe des alpha-hydroxy acides comme l'acide glycolique, l'acide citrique et l'acide malique. Produit naturellement par les muscles du corps humain, il est aussi synthétisé par certaines bactéries (bactéries à acide lactique).Lactic acid can be considered a "postbiotic" term used to define bacterial products or metabolites of probiotic organisms that have a biological activity on the host. Lactic acid belongs to the group of alpha-hydroxy acids such as glycolic acid, citric acid and malic acid. Naturally produced by the muscles of the human body, it is also synthesized by certain bacteria (lactic acid bacteria).
[00014] L'acide lactique étant une molécule chirale, on le trouve sous trois formes : D, L, ou DL. Les humains ne synthétisent que la forme L, tandis que les bactéries peuvent synthétiser les deux formes. L'acide lactique étant utilisé avant tout comme ingrédient alimentaire, on a tendance à trouver plus de forme L disponible. En utilisation cosmétique, on note moins d'irritations avec la forme L.Lactic acid being a chiral molecule, it is found in three forms: D, L, or DL. Humans only synthesize the L-form, while bacteria can synthesize both forms. Since lactic acid is used primarily as a food ingredient, there is a tendency to find more available L-form. In cosmetic use, there is less irritation with the L-shape.
[00015] Ces actifs en association, à savoir le au moins un prébiotique, la au moins une fraction probiotique et l'acide lactique sont des actifs hydrophiles et leur formulation dans des compositions pour application sur la peau, qui sont souvent des émulsions, présente un certain nombre de difficultés, notamment au niveau de la rhéologie ou de la viscosité ainsi que des problèmes de conservation et de déphasage.These assets in combination, namely the at least one prebiotic, the at least one probiotic fraction and lactic acid are hydrophilic active ingredients and their formulation in compositions for application to the skin, which are often emulsions, present a number of difficulties, particularly in terms of rheology or viscosity as well as problems of conservation and phase shift.
[00016] De façon surprenante ces problèmes ont pu être résolus par fixation du pH dans un intervalle compris entre 4 et 6, cet intervalle étant un intervalle de pH peu utilisé en formulation cosmétique.Surprisingly these problems could be solved by setting the pH in an interval between 4 and 6, this interval being a pH range little used in cosmetic formulation.
[00017] La présente invention concerne une composition, comprenant, en association : [00018] au moins un prébiotique ; - au moins une fraction probiotique et ; r de l'acide lactique.The present invention relates to a composition, comprising, in combination: [00018] at least one prebiotic; at least one probiotic fraction and; r lactic acid.
[00019] L'invention concerne également l'utilisation d'une composition selon l'une quelconque des revendications précédentes en tant que produir destiné à une application sur les phanères notamment la peau .The invention also relates to the use of a composition according to any one of the preceding claims as a product intended for application to superficial body growths, in particular the skin.
[00020] Dans un mode de réalisation, l'acide lactique est de forme L.In one embodiment, the lactic acid is L-shaped.
[00021] Dans un mode de réalisation, le prébiotique est choisi dans le groupe constitué par l'inuline et l'alphaglucane oligosaccharide.In one embodiment, the prebiotic is selected from the group consisting of inulin and alphaglucan oligosaccharide.
[00022] Ces composés sont commercialisés sous diverses formes et sous diverses dénominations et noms commerciaux dont certains exemples sont rassemblés à titre d'exemples dans le tableau 1.These compounds are marketed in various forms and under various denominations and trade names, some examples of which are given as examples in Table 1.
Tableau 1 [00023] Dans un mode de réalisation, la composition est caractérisée en ce que la fraction probiotique est choisie dans le groupe constitué par des lysats de probiotiques.Table 1 [00023] In one embodiment, the composition is characterized in that the probiotic fraction is selected from the group consisting of probiotic lysates.
[00024] Dans un mode de réalisation, le lysat de probiotique est un lysat du genre Bacillus.In one embodiment, the probiotic lysate is a lysate of the genus Bacillus.
[00025] Des probiotiques ou fractions probiotiques sont commercialisés sous diverses formes et sous diverses dénominations et noms commerciaux dont certains exemples sont rassemblées à titre d'exemples dans le tableau 2.[00025] Probiotics or probiotic fractions are marketed in various forms and under various names and trade names, some examples of which are given as examples in Table 2.
Tableau 2 [00026] Dans un mode de réalisation, la somme des teneurs en prébiotïque et en fraction probiotique est comprise entre 0,5 et 6 % en masse par rapport à la masse totale de ladite composition.Table 2 [00026] In one embodiment, the sum of the prebiotic and probiotic content is between 0.5 and 6% by weight relative to the total weight of said composition.
[00027] Dans un mode de réalisation, la somme des teneurs en prébiotique et en fraction probiotique est comprise entre 1 et 5 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the sum of the contents of prebiotic and probiotic fraction is between 1 and 5% by weight relative to the total mass of said composition.
[00028] Dans un mode de réalisation, la somme des teneurs en prébiotique et en fraction probiotique est comprise entre 2 et 4 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the sum of the contents of prebiotic and probiotic fraction is between 2 and 4% by weight relative to the total weight of said composition.
[00029] Dans un mode de réalisation, la teneur en prébiotique est comprise entre 0,5 et 2 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the prebiotic content is between 0.5 and 2% by weight relative to the total weight of said composition.
[00030] Dans un mode de réalisation, la teneur en prébiotique est comprise entre 0,5 et 1,5 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the prebiotic content is between 0.5 and 1.5% by weight relative to the total weight of said composition.
[00031] Dans un mode de réalisation, la teneur en prébiotique est comprise entre 0,75 et 1,25 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the prebiotic content is between 0.75 and 1.25% by weight relative to the total weight of said composition.
[00032] Dans un mode de réalisation, la teneur en acide lactique est comprise entre 0,5 et 5 en masse par rapport à la masse totale de ladite composition.In one embodiment, the lactic acid content is between 0.5 and 5 by weight relative to the total weight of said composition.
[00033] Dans un mode de réalisation, la teneur en acide lactique est comprise entre 1 et 4 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the lactic acid content is between 1 and 4% by weight relative to the total weight of said composition.
[00034] Dans un mode de réalisation, la teneur en acide lactique est comprise entre 2 et 3 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the lactic acid content is between 2 and 3% by weight relative to the total weight of said composition.
[00035] Dans un mode de réalisation, la teneur en fraction probiotique est comprise entre 0,5 et 4% en masse par rapport à la masse totale de ladite composition.In one embodiment, the content of probiotic fraction is between 0.5 and 4% by weight relative to the total weight of said composition.
Dans un mode de réalisation, la teneur en fraction probiotique est comprise entre 1 et 3 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the content of probiotic fraction is between 1 and 3% by weight relative to the total weight of said composition.
[00036] Dans un mode de réalisation, la teneur en fraction probiotique est comprise entre 1,5 et 2 % en masse par rapport à la masse totale de ladite composition.In one embodiment, the content of probiotic fraction is between 1.5 and 2% by weight relative to the total weight of said composition.
[00037] Dans un mode de réalisation, le au moins un prébiotique et la au moins une fraction probiotique forment un synbiotique.In one embodiment, the at least one prebiotic and the at least one probiotic fraction form a synbiotic.
[00038] Dans un mode de réalisation, le pH de la composition est compris entre 4 et 6.In one embodiment, the pH of the composition is between 4 and 6.
[00039] Dans un mode de réalisation, le pH de la composition est compris entre 5 et 5,5.In one embodiment, the pH of the composition is between 5 and 5.5.
[00040] Les compositions selon l'invention sont destinées à des applications sur les phanères, notamment sur la peau pour un usage cosmétique et ou pharmaceutique.The compositions according to the invention are intended for applications on integuments, especially on the skin for cosmetic and pharmaceutical use.
[00041] Les compostions selon l'invention pourront comprendre en outre des conservateurs en tenant compte des effets conservateurs de l'acide lactique.The compositions of the invention may further comprise preservatives taking into account the preservative effects of lactic acid.
[00042] Les actions des compositions selon l'invention sur la peau sont choisies dans le groupe constitué par : - action protectrice et rééquilibrante douce pour tous les types de peau ; - action favorisant la croissance de la flore microbienne bénéfique au détriment de la flore indésirable et pathogène ; - action de stimulation des mécanismes naturels de défense de la peau ; - action de stimulation sélective de la bonne flore cutanée ; - action d'inhibition de la croissance de la flore indésirable ; - action de stimulation des bêta-défensines de la peau ; - action d'amélioration de l'éclat et du confort de la peau; - action restructurante, nourrissante, lissante ; - action de réduction de la sensation d'inconfort ; - action d'augmentation du renouvellement cellulaire pour révéler une peau d'aspect plus jeune ; - action exfoliante pour tous les types de peau ; - action d'hydratation ; - action de réduction des rides et ridules.The actions of the compositions according to the invention on the skin are selected from the group consisting of: - protective action and rebalancing soft for all skin types; - action promoting the growth of beneficial microbial flora to the detriment of unwanted and pathogenic flora; - action of stimulation of the natural mechanisms of defense of the skin; - action of selective stimulation of the good cutaneous flora; action of inhibiting the growth of undesirable flora; - action of stimulation of the beta-defensins of the skin; - action to improve the radiance and comfort of the skin; - restructuring, nourishing, smoothing action; - action to reduce the feeling of discomfort; - action of increase of cellular renewal to reveal a skin of younger aspect; - exfoliating action for all skin types; - hydration action; - action to reduce wrinkles and fine lines.
[00043] Les compositions selon l'invention peuvent comprendre en outre les ingrédients classiques utilisés en formulation pharmaceutique et/ou cosmétique.The compositions according to the invention may further comprise the conventional ingredients used in pharmaceutical and / or cosmetic formulation.
[00044] La composition selon l'invention peut comprendre en outre des adjuvants classiques notamment choisis parmi les corps gras, les solvants organiques, les épaississants ioniques ou non ioniques, les adoucissants, les antioxydants, les opacifiants, les stabilisants, les émollients, les silicones, les α-hydroxyacides, les agents anti-mousse, les agents hydratants, les vitamines, les parfums, les conservateurs, les tensioactifs, les charges, les séquestrants, les polymères, les propulseurs, les agents alcalinisants ou acidifiants, les colorants, ou tout autre ingrédient habituellement utilisé pour la fabrication de compositions sous forme d'émulsions.The composition according to the invention may further comprise conventional adjuvants chosen in particular from fatty substances, organic solvents, ionic or nonionic thickeners, softeners, antioxidants, opacifiers, stabilizers, emollients, silicones, α-hydroxy acids, anti-foam agents, moisturizers, vitamins, perfumes, preservatives, surfactants, fillers, sequestering agents, polymers, propellants, basifying or acidifying agents, dyes, or any other ingredient usually used for the manufacture of compositions in the form of emulsions.
[00045] Les corps gras peuvent être constitués par une huile ou une cire ou leurs mélanges, et ils comprennent également les acides gras, les alcools gras et les esters d'acides gras. Les huiles peuvent être choisies parmi les huiles animales, végétales, minérales ou de synthèse et notamment parmi l'huile de vaseline, l'huile de paraffine, les huiles de silicone, volatiles ou non, les isoparaffines, les poly-a-oléfines, les huiles fluorées et perfluorées. De même, les cires peuvent être choisies parmi les cires animales, fossiles, végétales, minérales ou de synthèse connues en soi.The fatty substances may consist of an oil or a wax or mixtures thereof, and they also include fatty acids, fatty alcohols and fatty acid esters. The oils may be chosen from animal, vegetable, mineral or synthetic oils and in particular from liquid petroleum jelly, liquid paraffin, silicone oils, which may or may not be volatile, isoparaffins and poly-α-olefins. fluorinated and perfluorinated oils. Similarly, the waxes can be chosen from animal, fossil, vegetable, mineral or synthetic waxes known per se.
[00046] Parmi les solvants organiques, on peut citer les alcools et polyols inférieurs.Among the organic solvents, there may be mentioned lower alcohols and polyols.
[00047] Les épaississants peuvent être choisis notamment parmi les acides polyacryliques réticulés, les gommes Guar et celluloses modifiées ou non telles que la gomme Guar hydroxypropylée, la méthylhydroxyéthylcellulose et l'hydroxypropylméthylcellulose.The thickeners may be chosen in particular from crosslinked polyacrylic acids, guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, methylhydroxyethylcellulose and hydroxypropylmethylcellulose.
[00048] La composition selon l'invention peut être préparée selon les techniques bien connues de l'homme de l'art, en particulier celles destinées à la préparation d'émulsions de type huile-dans-eau (H/E) ou eau-dans-huile (E/H).The composition according to the invention may be prepared according to the techniques well known to those skilled in the art, in particular those intended for the preparation of oil-in-water (O / W) type emulsions or water -in-oil (W / O).
[00049] La composition selon l'invention peut se présenter en particulier sous forme d'émulsion, simple ou complexe (H/E, E/H, H/E/H ou E/H/E) telle qu'une crème, un lait, un gel ou un gel crème, de poudre, de bâtonnet solide et éventuellement être conditionnée en aérosol et se présenter sous forme de mousse ou de spray.The composition according to the invention may be in particular in emulsion form, simple or complex (O / W, W / O, O / W / H or W / O / W) such as a cream, a milk, a gel or a cream gel, powder, solid stick and possibly be packaged in aerosol and be in the form of foam or spray.
[00050] La composition selon l'invention peut en outre comprendre un ou plusieurs filtres solaires actifs dans l'UV-A et/ou l'UV-B, hydrophiles ou lipophiles.The composition according to the invention may further comprise one or more UV-A and / or UV-B active UV filters, hydrophilic or lipophilic.
[00051] Ces filtres peuvent être notamment choisis parmi les dérivés cinnamiques, les dérivés salicyliques, les dérivés du camphre, les dérivés de la triazine, les dérivés de la benzophénone, les dérivés du dibenzoylméthane, les dérivés de β,β-diphénylacrylate, les dérivés de l'acide p-aminobenzoïque, les filtres polymères et les filtres silicones [00052] La composition selon l'invention peut comprendre en outre des pigments ou bien encore des nanopigments d’oxydes métalliques enrobés ou non comme par exemple des nanopigments d’oxyde de titane (amorphe ou cristallisé sous forme rutile et/ou anatase) de fer, de zinc, de zirconium ou de cérium qui sont tous des agents photoprotecteurs connus agissant par blocage physique (réflexion et/ou diffusion) du rayonnement UV. Des agents d'enrobage classiques sont par ailleurs l'alumine et/ou le stéarate d'aluminium.These filters may be chosen from cinnamic derivatives, salicylic derivatives, camphor derivatives, triazine derivatives, benzophenone derivatives, dibenzoylmethane derivatives, β, β-diphenylacrylate derivatives, p-Aminobenzoic Acid Derivatives, Polymeric Filters and Silicone Filters The composition according to the invention may furthermore comprise pigments or else nanopigments of coated or uncoated metal oxides, for example nanopigments of titanium oxide (amorphous or crystallized in rutile form and / or anatase) of iron, zinc, zirconium or cerium which are all known photoprotective agents acting by physical blocking (reflection and / or diffusion) of UV radiation. Conventional coating agents are, moreover, alumina and / or aluminum stearate.
[00053] Les compositions selon l'invention suivantes ont été préparées, à titre d'exemples :The following compositions according to the invention have been prepared, by way of examples:
Exemple 1 :Example 1
Tableau 3 : Formulation 1 [00054]Table 3: Formulation 1 [00054]
Exemple 2 :Example 2
Tableau 4 : Formulation 2 Exemple 3Table 4: Formulation 2 Example 3
Tableau 5 : Formulation 3Table 5: Formulation 3
Exemple 4 :Example 4
Tableau 6 : Formulation 4Table 6: Formulation 4
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| WO2017173244A1 (en) * | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Topical composition for reducing pathogen binding |
| US10806769B2 (en) | 2016-03-31 | 2020-10-20 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| US10874700B2 (en) | 2016-03-31 | 2020-12-29 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| US11633451B2 (en) | 2016-03-31 | 2023-04-25 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| US11564879B2 (en) | 2016-11-23 | 2023-01-31 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| US20190151394A1 (en) * | 2017-11-17 | 2019-05-23 | Ying Tung Chen | Prebiotic Acne Treatment |
| FR3086172A1 (en) | 2018-09-26 | 2020-03-27 | Gallinee | COSMETIC FORMULATION |
| FR3086170A1 (en) | 2018-09-26 | 2020-03-27 | Gallinee | COSMETIC FORMULATION |
| WO2020064977A1 (en) | 2018-09-26 | 2020-04-02 | Gallinee | Cosmetic formulation |
| WO2020216757A1 (en) * | 2019-04-25 | 2020-10-29 | Universiteit Gent | Prebiotic skin care compositions containing carboxylic acids |
| US11998575B2 (en) | 2020-11-20 | 2024-06-04 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| WO2022219133A1 (en) * | 2021-04-16 | 2022-10-20 | Unilever Ip Holdings B.V. | Cleansing composition for female intimate hygiene |
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| Publication number | Publication date |
|---|---|
| FR3040624B1 (en) | 2019-07-26 |
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